Skip to main content
SpringerLink
Log in

Quantitative, False Positive, and False Negative Issues for Lateral Flow Immunoassays as Exemplified by Onsite Drug Screens

  • Chapter
  • First Online:
Lateral Flow Immunoassay

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Mandatory guidelines and proposed revisions to mandatory guidelines for federal workplace drug testing programs. April 13, 2004 (69 FR 19644).

    Google Scholar 

  2. Peace, M., Tarnai, L. and Poklis, A. (2000) Performance evaluation of four On-site drug-testing devices for detection of drugs of abuse in urine. J. Anal. Toxicol. 24:589–594.

    PubMed  CAS  Google Scholar 

  3. Moody, D.E., Fang, W.B., Andrenyak, D.M. and Monti, C. (2006) A comparative evaluation of the Instant-View 5-panel test card with OnTrak TesTcup Pro 5: comparison with gas chromatography-mass spectrometry. J. Anal. Toxicol. 30:50–56.

    PubMed  CAS  Google Scholar 

  4. Melanson, S.E.F., Lewandrowski, E.L., Griggs, D.A. and Flood, J.G. (2007) Interpreting tricyclic antidepressant measurements in urine in an emergency department setting: comparison of two qualitative point-of-care urine tricyclic antidepressant drug immunoassays with quantitative serum chromatographic analysis. J. Anal. Toxicol. 31:270–275.

    PubMed  CAS  Google Scholar 

  5. Kong, T.C. (2008) Clinical false-positive drug test results. In: “Handbook of drug monitoring methods”. Dasgupta, A., ed. Humana Press, Totowa, NJ, pp. 395–406.

    Chapter  Google Scholar 

  6. Rohrig, T.P. and Moore, C. (2003) The determination of morphine in urine and oral fluid following ingestion of poppy seeds. J. Anal. Toxicol. 27:449–452.

    PubMed  CAS  Google Scholar 

  7. Thevis, M., Opfermann, G. and Schanzer, W. (2003) Case report: urinary concentrations of morphine and codeine after consumption of poppy seeds. J. Anal. Toxicol. 27:53–56.

    Google Scholar 

  8. Practical challenges to positive drug tests for marijuana, Editorial. (2003) Clin. Chem. 49:1037–1038.

    Article  Google Scholar 

  9. Jenkins, A.J., Llosa, T., Montoya, I. and Cone, E.J. (1996) Identification and quantification of alkaloids in coca tea. Forensic Sci. Int. 77:179–189.

    Article  PubMed  CAS  Google Scholar 

  10. Mazor, S.S., Mycyk, M.B., Wills, B.K., Brace, L.D., Gussow, L. and Erickson, T. (2006) Coca tea consumption causes positive urine cocaine assay. Eur. J. Emerg. Med. 13:340–341.

    Article  PubMed  Google Scholar 

  11. Bowen, R., George, D. and Hortin, G. (2005) False-negative results for cocaine metabolites on a lateral-flow drug test slide corrected by dilution. Clin. Chem. 51:790–791.

    Article  PubMed  CAS  Google Scholar 

  12. Tomkins, B.A., Van Berkel, G.J., Jenkins, R.A. and Counts, R.W. (2006) Quantitation of cotinine in nonsmoker saliva using chip-based nanoelectrospray tandem mass spectrometry. J. Anal. Toxicol. 30:178–186.

    PubMed  CAS  Google Scholar 

  13. Stout, P.R., Hron, C.K., Klette, K.L. and Given, J. (2006) Occupational exposure to methamphetamine in workers preparing training aids for drug detection dogs. J. Anal. Toxicol. 30:551–553.

    PubMed  CAS  Google Scholar 

  14. Wong, R.C. and Tse, H.Y. (2005) Adulteration detection by Intect® 7. In: “Drugs of abuse: Body fluid testing”. Wong, R.C. and Tse, H.Y., eds. Humana Press, Totowa, NJ, pp. 233–245.

    Google Scholar 

  15. Peace, M.R. and Tarnai, L.D. (2002) Performance evaluation of three on-site adulterant detection devices for urine specimens. J. Anal. Toxicol. 26:464–470.

    PubMed  CAS  Google Scholar 

  16. http://www.passyourdrugtest.com/false-positives.htm

  17. Medical Review Officer Manual for Federal Agency Workplace Drug Testing Programs. US Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Division of Workplace Programs. Available at: http://dwp.samhsa.gov/DrugTesting/Level_1_Pages/HHS%20MRO%20Manual%20(Effective%201,%202004. Accessed 5/12/2008.

  18. Kraemer, T., Roditis, S., Peters, F. and Maurer, H. (2003) Amphetamine concentrations in human urine following single-dose administration of the calcium antagonist Prenylamine—Studies using fluorescence polarization immunoassay (FPIA) and GC-MS. J. Anal. Toxicol. 27:68–73.

    PubMed  CAS  Google Scholar 

  19. Sena, S., Kazimi, S. and Wu A. (2002) False-positive phencyclidine immunoassay results caused by Venlafaxine and O-Desmethylvenlafaxine. Clin. Chem. 48:676–677.

    PubMed  CAS  Google Scholar 

  20. Santos, P.M., Lopez-Garcia, P., Navarro, J.S., Fernandez, A.S., Sadaba, B. and Vidal, J.P. (2007) False positive phencyclidine results caused by Venlafaxine. Am. J. Psychiatry 164:349.

    Article  PubMed  Google Scholar 

  21. Lewis, J.H. (1999) Interference of Gemfibrozil with Roche Testcup. J. Anal. Toxicol. 23:384.

    PubMed  CAS  Google Scholar 

  22. Leino, A., Saarimies, J., Gronholm, M. and Lillsunde, P. (2001) Comparison of eight commercial onsite screening devices for drugs-of-abuse testing. Scand. J. Clin. Lab. Invest. 61:325–331.

    Article  PubMed  CAS  Google Scholar 

  23. Manzi, S., Law, T. and Shannon, M.W. (2002) Methylphenidate produces a false-positive urine amphetamine screen. Pediat. Emerg. Care. 18:401.

    Article  Google Scholar 

  24. Rossi, S., Yaksh, T., Bentley, H., van den Brande, G., Grant, I. and Ellis, R. (2006) Characterization of interference with 6 commercial Δ9-tetrahydrocannabinol immunoassays by Efavirenz (Glucuronide) in urine. Clin. Chem. 52:896–897.

    CAS  Google Scholar 

  25. Daher, R., Haidar, J.H. and Al-Amin, H. (2002) Rifampin interference with opiate immunoassays. Clin. Chem. 48:203–204.

    PubMed  CAS  Google Scholar 

  26. http://www.fda.gov/cder/foi/label/2004/20987slr020_protonix_lbl.pdf. Accessed 5/18/2008.

  27. Widschwendter, C.G., Zernig, G. and Hofer, A. (2007) Quetiapine cross reactivity with urine methadone immunoassays. Am. J. Psychiatry 164:172.

    Article  PubMed  Google Scholar 

  28. Hendrickson, R.G. and Morocco, A.P. (2003) Quetiapine cross-reactivity among three tricyclic antidepressant immunoassays. J. Anal. Toxicol. 41:105–108.

    CAS  Google Scholar 

  29. Zacher, J. (2004) False-positive urine opiate screening associated with Fluoroquinolone use. Ann. Pharmacothe. 38:1525–1528.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Branan Medical Corporation, 140, Technology Drive, Suite 400, Irvine, CA, USA

    Raphael C. Wong

Authors
  1. Raphael C. Wong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Harley Y. Tse
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Raphael C. Wong .

Editor information

Editors and Affiliations

  1. Branan Medical Corporation, Muirlands Rd. 10015, Irvine, 92618, U.S.A.

    Raphael Wong

  2. School of Medicine, Dept. Immunology & Microbiology, Wayne State University, E. Canfield Ave. 540, Detroit, 48201, U.S.A.

    Harley Tse

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Wong, R.C., Tse, H.Y. (2009). Quantitative, False Positive, and False Negative Issues for Lateral Flow Immunoassays as Exemplified by Onsite Drug Screens. In: Wong, R., Tse, H. (eds) Lateral Flow Immunoassay. Humana Press. https://doi.org/10.1007/978-1-59745-240-3_10

Download citation

Publish with us

Policies and ethics

Search

Navigation