Skip to main content

Aspects of Percutaneous Cellular Cardiomyoplasty

  • Chapter
Stem Cells And Myocardial Regeneration

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

The significant advances achieved over the past decade in the field of percutaneous coronary intervention have significantly increased our ability to use catheter-based techniques to modify cardiac physiology. The ongoing studies demonstrating the significant potential of cell-based therapy for the prevention and treatment of chronic heart failure has led to the development of multiple catheter-based systems for the delivery of cells to the injured myocardium. Advances have also been made in catheter-based systems that exploit electomechanical properties of the heart in order to direct the interventionalist as to the best areas in which to inject cells. In this chapter we will review the different catheter systems currently available or under development as well as discuss how different features of each may be optimal in the different settings of acute myocardial infarction and chronic heart failure.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Amado LC, Saliaris AP, Schuleri KH, et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci USA 2005;102(32):11,474–11,479.

    Article  PubMed  CAS  Google Scholar 

  2. Chachques JC, Salanson-Lajos C, Lajos P, Shafy A, Alshamry, Carpentier A. Cellular cardiomyoplasty for myocardial regeneration. Asian Cardiovasc Thorac Ann 2005;13:287–296.

    PubMed  Google Scholar 

  3. Siminiak T, Fiszer D, Jerzykowska O, et al. Percutaneous trans-coronary-venous transplantation of autologous skeletal myoblasts in the treatment of post-infarction myocardial contractility impairment: the POZNAN trial. Eur Heart J 2005;26:1188–1195.

    Article  PubMed  Google Scholar 

  4. Perin EC, Silva GV. Stem cell therapy for cardiac diseases. Curr Opin Hematol 2004;11:399–403.

    Article  PubMed  Google Scholar 

  5. Orlic D. BM stem cells and cardiac repair: where do we stand in 2004? Cytotherapy 2005;7:3–15.

    Article  PubMed  CAS  Google Scholar 

  6. Kang HJ, Kim HS, Zhang SY, et al. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet 2004;363:751–756.

    Article  PubMed  CAS  Google Scholar 

  7. Wollert KC, Meyer GP, Lotz J, et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2004;364:141–148.

    Article  PubMed  Google Scholar 

  8. Perin EC, Dohmann HF, Borojevic R, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003;107(18):2294–2302.

    Article  PubMed  Google Scholar 

  9. Kawamoto A, Tkebuchava T, Yamaguchi J, et al. Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia. Circulation 2003;107:461–468.

    Article  PubMed  Google Scholar 

  10. Losordo DW, Vale PR, Hendel RC, et al. Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia. Circulation 2002;105:2012–2018.

    Article  PubMed  CAS  Google Scholar 

  11. Gyongyosi M, Sochor H, Khorsand A, Gepstein L, Glogar D. Online myocardial viability assessment in the catheterization laboratory via NOGA electroanatomic mapping: quantitative comparison with thallium-201 uptake. Circulation 2001;104:1005–1011.

    Article  PubMed  CAS  Google Scholar 

  12. Lessick J, Kornowski R, Fuchs S, Ben Haim SA. Assessment of NOGA catheter stability during the entire cardiac cycle by means of a special needle-tipped catheter. Catheter Cardiovasc Interv 2001;52:400–406.

    Article  PubMed  CAS  Google Scholar 

  13. Corti R, Badimon J, Mizseif G, et al. Real time magnetic resonance guided endomyocardial local delivery. Heart 2005;91(3):348–353.

    Article  PubMed  CAS  Google Scholar 

  14. Gyongyosi M, Khorsand A, Sochor H, et al. Characterization of hibernating myocardium with NOGA electroanatomic endocardial mapping. Am J Cardiol 2005;95:722–728.

    Article  PubMed  Google Scholar 

  15. Gyongyosi M, Khorsand A, Zamini S, et al. NOGA-guided analysis of regional myocardial perfusion abnormalities treated with intramyocardial injections of plasmid encoding vascular endothelial growth factor A-165 in patients with chronic myocardial ischemia: subanalysis of the EUROINJECT-ONE multicenter double-blind randomized study. Circulation 2005;112:I157–I165.

    Article  PubMed  Google Scholar 

  16. Karmarkar PV, Kraitchman DL, Izbudak I, et al. MR-trackable intramyocardial injection catheter. Magn Reson Med 2004;51:1163–1172.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Humana Press Inc., Totowa, NJ

About this chapter

Cite this chapter

Hook, M., Whitlow, P. (2007). Aspects of Percutaneous Cellular Cardiomyoplasty. In: Penn, M.S. (eds) Stem Cells And Myocardial Regeneration. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-59745-272-4_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-59745-272-4_13

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-664-1

  • Online ISBN: 978-1-59745-272-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics