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Imaging Genes for Viral and Adoptive Therapies

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In Vivo Imaging of Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

The concept of using gene therapy for cancer treatment was initially met with enthusiasm. The possibility of replacing or altering damaged genes, the introduction of suicide genes into cancer cells, and the alteration of cell function as a consequence of exogenous gene expression were advocated. Therapeutic genes can be transferred to patients through a variety of vehicles. These include retroviruses, herpes viruses, adenoviruses, adeno-associated viruses, lentiviruses, baculoviruses, liposomes, bacterial hosts, naked DNA, DNA precipitates, and protein-DNA conjugates (Table 1) (1,2). However, the practical application of gene therapy to treat cancer has been somewhat disappointing so far. Major obstacles remain, including the inability to target appropriate tissues and deliver therapeutic genes to a sufficient number of target cells, the inability to monitor the level of expression of the therapeutic gene, the loss of therapeutic gene expression over time, and the inability to correlate the level and duration of gene expression with therapeutic outcome.

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Authors and Affiliations

  1. Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY

    Inna Serganova PhD, Vladimir Ponomarev MD, PhD, Phillipp Mayer-Kuckuk PhD, Ekaterina Doubrovina MD, PhD, Michael Doubrovin MD, PhD & Ronald G. Blasberg MD

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  1. Inna Serganova PhD
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  2. Vladimir Ponomarev MD, PhD
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  3. Phillipp Mayer-Kuckuk PhD
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  4. Ekaterina Doubrovina MD, PhD
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  5. Michael Doubrovin MD, PhD
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  6. Ronald G. Blasberg MD
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Editors and Affiliations

  1. Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI

    Anthony F. Shields

  2. Manchester Molecular Imaging Center Christie Hospital NHS Trust Academic Department of Radiation Oncology, The University of Manchester Wolfson Molecular Imaging Centre, Manchester, UK

    Pat Price

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Serganova, I., Ponomarev, V., Mayer-Kuckuk, P., Doubrovina, E., Doubrovin, M., Blasberg, R.G. (2007). Imaging Genes for Viral and Adoptive Therapies. In: Shields, A.F., Price, P. (eds) In Vivo Imaging of Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-341-7_12

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