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PET and PET-CT Imaging of Adrenal Lesions

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Adrenal Imaging

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References

  1. Khan TS, Sundin A, Juhlin C, Langstrom B, Bergstrom M, Eriksson B (2003) 11C-Metomidate PET imaging of adrenocortical cancer. Eur J Nucl Med Mol Imaging 30(3):403–410

    Article  PubMed  Google Scholar 

  2. Brown RS, Leung JY, Fisher SJ, Frey KA, Ethier SP, Wahl RL (1996) Intratumoral distribution of tritiated-FDG in breast carcinoma: correlation between Glut-1 expression and FDG uptake. J Nucl Med 37(6):1042–1047

    PubMed  CAS  Google Scholar 

  3. Higashi K, Clavo AC, Wahl RL (1993) Does FDG uptake measure proliferative activity of human cancer cells? In vitro comparison with DNA flow cytometry and tritiated thymidine uptake. J Nucl Med 34(3):414–419

    PubMed  CAS  Google Scholar 

  4. Von Schulthess GK, Steinert HC, Hany TF (2006) Integrated PET/CT: current applications and future directions. Radiology 238(2):405–422

    Article  Google Scholar 

  5. Cohade C, Wahl RL (2003) Applications of positron emission tomography/computed tomography image fusion in clinical positron emission tomography – clinical use, interpretation methods, diagnostic improvements. Semin Nucl Med 33(3):228–237

    Article  PubMed  Google Scholar 

  6. Bagheri B, Maurer AH, Cone L, Doss M, Adler L (2004) Characterization of the normal adrenal gland with 18F-FDG PET/CT. J Nucl Med 45(8):1340–1343

    PubMed  Google Scholar 

  7. Karstaedt N, Sagel SS, Stanley RJ, Melson GL, Levitt RG (1978) Computed tomography of the adrenal gland. Radiology 129(3):723–730

    PubMed  CAS  Google Scholar 

  8. Abrams HL, Siegelman SS, Adams DF, Sanders R, Finberg HJ, Hessel SJ, McNeil BJ (1982) Computed tomography versus ultrasound of the adrenal gland: a prospective study. Radiology 143(1):121–128

    PubMed  CAS  Google Scholar 

  9. Hedeland H, Ostberg G, Hokfelt B (1968) On the prevalence of adrenocortical adenomas in an autopsy material in relation to hypertension and diabetes. Acta Med Scand 184(3):211–214

    PubMed  CAS  Google Scholar 

  10. Korobkin M, Francis IR, Kloos RT, Dunnick NR (1996) The incidental adrenal mass. Radiol Clin North Am 34(5):1037–1054

    PubMed  CAS  Google Scholar 

  11. Paulsen SD, Nghiem HV, Korobkin M, Caoili EM, Higgins EJ (2004) Changing role of imaging-guided percutaneous biopsy of adrenal masses: evaluation of 50 adrenal biopsies. AJR Am J Roentgenol 182(4):1033–1037

    PubMed  Google Scholar 

  12. Dunnick NR, Korobkin M (2002) Imaging of adrenal incidentalomas: current status. AJR Am J Roentgenol 179(3):559–568

    PubMed  Google Scholar 

  13. Kocijancic I, Vidmar K, Zwitter M, Snoj M (2003) The significance of adrenal metastases from lung carcinoma. Eur J Surg Oncol 29(1):87–88

    Article  PubMed  CAS  Google Scholar 

  14. Boland GW, Goldberg MA, Lee MJ, Mayo-Smith WW, Dixon J, McNicholas MM, Mueller PR (1995) Indeterminate adrenal mass in patients with cancer: evaluation at PET with 2-[F-18]-fluoro-2-deoxy-D-glucose. Radiology 194(1):131–134

    PubMed  CAS  Google Scholar 

  15. Erasmus JJ, Patz EF Jr, McAdams HP, Murray JG, Herndon J, Coleman RE, Goodman PC (1997) Evaluation of adrenal masses in patients with bronchogenic carcinoma using 18F-fluorodeoxyglucose positron emission tomography. AJR Am J Roentgenol 168(5):1357–1360

    PubMed  CAS  Google Scholar 

  16. Maurea S, Mainolfi C, Bazzicalupo L, Panico MR, Imparato C, Alfano B, Ziviello M, Salvatore M (1999) Imaging of adrenal tumors using FDG PET: comparison of benign and malignant lesions. AJR Am J Roentgenol 173(1):25–29

    PubMed  CAS  Google Scholar 

  17. Yun M, Kim W, Alnafisi N, Lacorte L, Jang S, Alavi A (2001) 18F-FDG PET in characterizing adrenal lesions detected on CT or MRI. J Nucl Med 42(12):1795–1799

    PubMed  CAS  Google Scholar 

  18. Gupta NC, Graeber GM, Tamim WJ, Rogers JS, Irisari L, Bishop HA (2001) Clinical utility of PET-FDG imaging in differentiation of benign from malignant adrenal masses in lung cancer. Clin Lung Cancer 3(1):59–64

    Article  PubMed  CAS  Google Scholar 

  19. Kumar R, Xiu Y, Yu JQ, Takalkar A, El Haddad G, Potenta S, Kung J, Zhuang H, Alavi A (2004) 18F-FDG PET in evaluation of adrenal lesions in patients with lung cancer. J Nucl Med 45(12):2058–2062

    PubMed  Google Scholar 

  20. Jana S, Zhang T, Milstein DM, Isasi CR, Blaufox MD (2006) FDG-PET and CT characterization of adrenal lesions in cancer patients. Eur J Nucl Med Mol Imaging 33(1):29–35

    Article  PubMed  Google Scholar 

  21. Metser U, Miller E, Lerman H, Lievshitz G, Avital S, Even-Sapir E (2006) 18F-FDG PET/CT in the evaluation of adrenal masses. J Nucl Med 47(1):32–37

    PubMed  Google Scholar 

  22. Blake MA, Slattery JM, Kalra MK, Halpern EF, Fischman AJ, Mueller PR, Boland GW (2006) Adrenal lesions: characterization with fused PET/CT image in patients with proved or suspected malignancy – initial experience. Radiology 238(3):970–977

    Article  PubMed  Google Scholar 

  23. Caoili EM, Korobkin M, Brown RK, Mackie G, Shulkin BL (2007) Differentiating adrenal adenomas from nonadenomas using (18)F-FDG PET/CT quantitative and qualitative evaluation. Acad Radiol 14(4):468–475

    Article  PubMed  Google Scholar 

  24. Jaskowiak CJ, Bianco JA, Perlman SB, Fine JP (2005) Influence of reconstruction iterations on 18F-FDG PET/CT standardized uptake values. J Nucl Med 46(3):424–428

    PubMed  Google Scholar 

  25. Stahl A, Ott K, Schwaiger M, Weber WA (2004) Comparison of different SUV-based methods for monitoring cytotoxic therapy with FDG PET. Eur J Nucl Med Mol Imaging 31(11):1471–1478

    Article  PubMed  CAS  Google Scholar 

  26. Zasadny KR, Wahl RL (1993) Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose: variations with body weight and a method for correction. Radiology 189(3):847–850

    PubMed  CAS  Google Scholar 

  27. Bakheet SM, Powe J, Ezzat A, Rostom A (1998) F-18-FDG uptake in tuberculosis. Clin Nucl Med 23(11):739–742

    Article  PubMed  CAS  Google Scholar 

  28. Boerner AR, Voth E, Theissen P, Wienhard K, Wagner R, Schicha H (1998) Glucose metabolism of the thyroid in Graves' Disease measured by F-18-fluoro-deoxyglucose positron emission tomography. Thyroid 8(9):765–772

    Article  PubMed  CAS  Google Scholar 

  29. Shimizu A, Oriuchi N, Tsushima Y, Higuchi T, Aoki J, Endo K (2003) High [18F] 2-fluoro-2-deoxy-D-glucose (FDG) uptake of adrenocortical adenoma showing subclinical Cushing's Syndrome. Ann Nucl Med 17(5):403–406

    Article  PubMed  Google Scholar 

  30. Shulkin BL, Thompson NW, Shapiro B, Francis IR, Sisson JC (1999) Pheochromocytomas: imaging with 2-[fluorine-18]fluoro-2-deoxy-D-glucose PET. Radiology 212(1):35–41

    PubMed  CAS  Google Scholar 

  31. Barzon L, Boscaro M (2000) Diagnosis and management of adrenal incidentalomas. J Urol 163(2):398–407

    Article  PubMed  CAS  Google Scholar 

  32. Bertherat J, Mosnier-Pudar H, Bertagna X (2002) Adrenal incidentalomas. Curr Opin Oncol 14(1):58–63

    Article  PubMed  Google Scholar 

  33. Mody MK, Kazerooni EA, Korobkin M (1995) Percutaneous CT-guided biopsy of adrenal masses: immediate and delayed complications. J Comput Assist Tomogr 19(3):434–439

    Article  PubMed  CAS  Google Scholar 

  34. Silverman SG, Mueller PR, Pinkney LP, Koenker RM, Seltzer SE (1993) Predictive value of image-guided adrenal biopsy: analysis of results of 101 biopsies. Radiology 187(3):715–718

    PubMed  CAS  Google Scholar 

  35. Korobkin M, Brodeur FJ, Yutzy GG, Francis IR, Quint LE, Dunnick NR, Kazerooni EA (1996) Differentiation of adrenal adenomas from nonadenomas using CT attenuation values. AJR Am J Roentgenol 166(3):531–536

    PubMed  CAS  Google Scholar 

  36. Boland GW, Lee MJ, Gazelle GS, Halpern EF, McNicholas MM, Mueller PR (1998) Characterization of adrenal masses using unenhanced CT: an analysis of the CT literature. AJR Am J Roentgenol 171(1):201–204

    PubMed  CAS  Google Scholar 

  37. Lee MJ, Hahn PF, Papanicolaou N, Egglin TK, Saini S, Mueller PR, Simeone JF (1991) Benign and malignant adrenal masses: CT distinction with attenuation coefficients, size, and observer analysis. Radiology 179(2):415–418

    PubMed  CAS  Google Scholar 

  38. Korobkin M, Brodeur FJ, Francis IR, Quint LE, Dunnick NR, Goodsitt M (1996) Delayed enhanced CT for differentiation of benign from malignant adrenal masses. Radiology 200(3):737–742

    PubMed  CAS  Google Scholar 

  39. Mitchell DG, Crovello M, Matteucci T, Petersen RO, Miettinen MM (1992) Benign adrenocortical masses: diagnosis with chemical shift MR imaging. Radiology 185(2):345–351

    PubMed  CAS  Google Scholar 

  40. Outwater EK, Siegelman ES, Huang AB, Birnbaum BA (1996) Adrenal masses: correlation between CT attenuation value and chemical shift ratio at MR imaging with in-phase and opposed-phase sequences. Radiology 200(3):749–752

    PubMed  CAS  Google Scholar 

  41. Tsushima Y, Ishizaka H, Matsumoto M (1993) Adrenal masses: differentiation with chemical shift, fast low-angle shot MR imaging. Radiology 186(3):705–709

    PubMed  CAS  Google Scholar 

  42. MacManus MP, Hicks RJ, Matthews JP, Hogg A, McKenzie AF, Wirth A, Ware RE, Ball DL (2001) High rate of detection of unsuspected distant metastases by pet in apparent stage III non-small-cell lung cancer: implications for radical radiation therapy. Int J Radiat Oncol Biol Phys 50(2):287–293

    Article  PubMed  CAS  Google Scholar 

  43. Alves A, Scatton O, Dousset B (2002) Diagnostic and therapeutic strategy for an incidental finding of an adrenal mass [in French]. J Chir (Paris) 139(4):205–213

    CAS  Google Scholar 

  44. Siren JE, Haapiainen RK, Huikuri KT, Sivula AH (1993) Incidentalomas of the adrenal gland: 36 operated patients and review of literature. World J Surg 17(5):634–639

    Article  PubMed  CAS  Google Scholar 

  45. Wooten MD, King DK (1993) Adrenal cortical cCarcinoma. Epidemiology and treatment with Mitotane and a review of the piterature. Cancer 72(11):3145–3155

    Article  PubMed  CAS  Google Scholar 

  46. Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA, Zerbini MC, Liberman B, Carlos Gomes G, Kirschner MA (2000) Adrenocortical carcinoma: clinical and laboratory observations. Cancer 88(4):711–736

    Article  PubMed  CAS  Google Scholar 

  47. Zettinig G, Mitterhauser M, Wadsak W, Becherer A, Pirich C, Vierhapper H, Niederle B, Dudczak R, Kletter K (2004) Positron emission tomography imaging of adrenal masses: (18)F-fluorodeoxyglucose and the 11beta-hydroxylase tracer (11)C-metomidate. Eur J Nucl Med Mol Imaging 31(9):1224–1230

    Article  PubMed  Google Scholar 

  48. Becherer A, Vierhapper H, Potzi C, Karanikas G, Kurtaran A, Schmaljohann J, Staudenherz A, Dudczak R, Kletter K (2001) FDG-PET in adrenocortical carcinoma. Cancer Biother Radiopharm 16(4):289–295

    Article  PubMed  CAS  Google Scholar 

  49. Leboulleux S, Dromain C, Bonniaud G, Auperin A, Caillou B, Lumbroso J, Sigal R, Baudin E, Schlumberger M (2006) Diagnostic and prognostic value of 18-fluorodeoxyglucose positron emission yomography in adrenocortical carcinoma: a prospective comparison with computed tomography. J Clin Endocrinol Metab 91(3):920–925

    Article  PubMed  CAS  Google Scholar 

  50. Mackie GC, Shulkin BL, Ribeiro RC, Worden FP, Gauger PG, Mody RJ, Connolly LP, Kunter G, Rodriguez-Galindo C, Wallis JW, Hurwitz CA, Schteingart DE (2006) Use of [18F]fluorodeoxyglucose positron emission tomography in evaluating locally recurrent and metastatic adrenocortical carcinoma. J Clin Endocrinol Metab 91(7):2665–2671

    Article  PubMed  CAS  Google Scholar 

  51. Weber MM, Lang J, Abedinpour F, Zeilberger K, Adelmann B, Engelhardt D (1993) Different inhibitory effect of etomidate and ketoconazole on the human adrenal steroid biosynthesis. Clin Investig 71(11):933–938

    Article  PubMed  CAS  Google Scholar 

  52. Bergstrom M, Bonasera TA, Lu L, Bergstrom E, Backlin C, Juhlin C, Langstrom B (1998) In vitro and in vivo primate evaluation of carbon-11-etomidate and carbon-11-metomidate as potential tracers for PET imaging of the adrenal cortex and its tumors. J Nucl Med 39(6):982–989

    PubMed  CAS  Google Scholar 

  53. Bergstrom M, Juhlin C, Bonasera TA, Sundin A, Rastad J, Akerstrom G, Langstrom B (2000) PET imaging of adrenal cortical tumors with the 11beta-hydroxylase tracer 11C-metomidate. J Nucl Med 41(2):275–282

    PubMed  CAS  Google Scholar 

  54. Minn H, Salonen A, Friberg J, Roivainen A, Viljanen T, Langsjo J, Salmi J, Valimaki M, Nagren K, Nuutila P (2004) Imaging of adrenal incidentalomas with PET using (11)C-metomidate and (18)F-FDG. J Nucl Med 45(6):972–979

    PubMed  CAS  Google Scholar 

  55. Hennings J, Lindhe O, Bergstrom M, Langstrom B, Sundin A, Hellman P (2006) [11C]Metomidate positron emission tomography of adrenocortical tumors in correlation with histopathological findings. J Clin Endocrinol Metab 91(4):1410–1414

    Article  PubMed  CAS  Google Scholar 

  56. Mitterhauser M, Wadsak W, Wabnegger L, Sieghart W, Viernstein H, Kletter K, Dudczak R (2003) In vivo and in vitro evaluation of [18F]FETO with respect to the adrenocortical and GABAergic system in rats. Eur J Nucl Med Mol Imaging 30(10):1398–1401

    Article  PubMed  CAS  Google Scholar 

  57. Wadsak W, Mitterhauser M, Rendl G, Schuetz M, Mien LK, Ettlinger DE, Dudczak R, Kletter K, Karanikas G (2006) [18F]FETO for adrenocortical PET imaging: a pilot study in healthy volunteers. Eur J Nucl Med Mol Imaging 33(6):669–672

    Article  PubMed  Google Scholar 

  58. Moreira SG Jr, Pow-Sang JM (2002) Evaluation and management of adrenal masses. Cancer Control 9(4):326–334

    PubMed  Google Scholar 

  59. Fujita A, Hyodoh H, Kawamura Y, Kanegae K, Furuse M, Kanazawa K (2000) Use of fusion images of I-131 metaiodobenzylguanidine, SPECT, and magnetic resonance studies to identify a malignant pheochromocytoma. Clin Nucl Med 25(6):440–442

    Article  PubMed  CAS  Google Scholar 

  60. Sisson JC, Shulkin BL (1999) Nuclear medicine imaging of pheochromocytoma and neuroblastoma. Q J Nucl Med 43(3):217–223

    PubMed  CAS  Google Scholar 

  61. Eisenhofer G, Pacak K, Goldstein DS, Chen C, Shulkin B (2000) 123I-MIBG scintigraphy of catecholamine systems: impediments to applications in clinical medicine. Eur J Nucl Med 27(5):611–612

    PubMed  CAS  Google Scholar 

  62. Shulkin BL, Wieland DM, Schwaiger M, Thompson NW, Francis IR, Haka MS, Rosenspire KC, Shapiro B, Sisson JC, Kuhl DE (1992) PET scanning with hydroxyephedrine: an approach to the localization of pheochromocytoma. J Nucl Med 33(6):1125–1131

    PubMed  CAS  Google Scholar 

  63. Trampal C, Engler H, Juhlin C, Bergstrom M, Langstrom B (2004) Pheochromocytomas: detection with 11C hydroxyephedrine PET. Radiology 230(2):423–428

    Article  PubMed  Google Scholar 

  64. Mann GN, Link JM, Pham P, Pickett CA, Byrd DR, Kinahan PE, Krohn KA, Mankoff DA (2006) [11C]Metahydroxyephedrine and [18F]fluorodeoxyglucose positron emission tomography improve clinical decision making in suspected pheochromocytoma. Ann Surg Oncol 13(2):187–197

    Article  PubMed  Google Scholar 

  65. Ilias I, Yu J, Carrasquillo JA, Chen CC, Eisenhofer G, Whatley M, McElroy B, Pacak K (2003) Superiority of 6-[18F]-fluorodopamine positron emission tomography versus [131I]-metaiodobenzylguanidine scintigraphy in the localization of metastatic pheochromocytoma. J Clin Endocrinol Metab 88(9):4083–4087

    Article  PubMed  CAS  Google Scholar 

  66. Pacak K, Eisenhofer G, Carrasquillo JA, Chen CC, Whatley M, Goldstein DS (2002) Diagnostic localization of pheochromocytoma: the coming of age of positron emission tomography. Ann N Y Acad Sci 970:170–176

    Article  PubMed  CAS  Google Scholar 

  67. Pacak K, Eisenhofer G, Carrasquillo JA, Chen CC, Li ST, Goldstein D (2001) S. 6-[18F]Fluorodopamine positron emission tomographic (PET) scanning for diagnostic localization of pheochromocytoma. Hypertension 38(1):6–8

    Article  PubMed  CAS  Google Scholar 

  68. Hoegerle S, Nitzsche E, Altehoefer C, Ghanem N, Manz T, Brink I, Reincke M, Moser E, Neumann HP (2002) Pheochromocytomas: detection with 18F DOPA whole body PET – initial results. Radiology 222(2):507–512

    Article  PubMed  Google Scholar 

  69. Berry CR, DeGrado TR, Nutter F, Garg PK, Breitschwerdt EB, Spaulding K, Concannon KD, Zalutsky MR, Coleman RE (2002) Imaging of pheochromocytoma in 2 dogs using P-[18F] fluorobenzylguanidine. Vet Radiol Ultrasound 43(2):183–186

    Article  PubMed  Google Scholar 

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Roedl, J.B., Boland, G.W.L., Blake, M.A. (2009). PET and PET-CT Imaging of Adrenal Lesions. In: Blake, M., Boland, G. (eds) Adrenal Imaging. Contemporary Medical Imaging. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59745-560-2_11

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