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PIK3CA Gene Alterations in Human Cancers

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Bioinformatics in Cancer and Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Mutations or amplification of the chromosomal region containing the PIK3CA gene, coding for the p110α catalytic subunit of class IA of PI3K, were described in diverse tumor models. In this review, we will focus on the localization and type of PIK3CA mutations and their association with signaling pathways and cellular effects in different tumor types.

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Authors and Affiliations

  1. Institute of Pathology and Molecular Immunology, University of Porto (IPATIMUP), Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal

    Sérgia Velho, Carla Oliveira & Raquel Seruca

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  1. Sérgia Velho
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  2. Carla Oliveira
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  3. Raquel Seruca
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  1. Division of Thoracic Surgery, Brigham & Women's Hospital, Longwood Ave. 221, Boston, 02115, U.S.A.

    Gavin J. Gordon

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Velho, S., Oliveira, C., Seruca, R. (2009). PIK3CA Gene Alterations in Human Cancers. In: Gordon, G. (eds) Bioinformatics in Cancer and Cancer Therapy. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-576-3_10

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