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The Corticostriatal Pathway in Parkinson’s Disease

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Cortico-Subcortical Dynamics in Parkinson's Disease

Part of the book series: Contemporary Neuroscience ((CNEURO))

The cortico-basal ganglia-thalamocortical loop participates in the regulation of motor movements and goal-directed behaviors [1–4]. Parkinson’s disease (PD), as well as other neurodegenerative disorders that affect motor function, is associated with abnormal neurotransmission along this pathway [5–7]. In this chapter, we will examine how a reduction of dopamine availability in PD produces striatal synaptic plasticity. These striatal adaptations might be sufficient to produce bradykinesia in the dopamine-deficient state and motor dyskinesias following treatment. Although changes occur at several levels of the cortico-basal ganglia-thalamocortical loop, the focus of this chapter is on the corticostriatal synapse.

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  1. Department of Neurology, Pediatrics and Psychology, University of Washington, Seattle

    Nigel S. Bamford & Carlos Cepeda

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    Bamford, N.S., Cepeda, C. (2009). The Corticostriatal Pathway in Parkinson’s Disease. In: Tseng, KY. (eds) Cortico-Subcortical Dynamics in Parkinson's Disease. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-60327-252-0_6

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