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Neurohumoral Regulation of Blood Pressure in Early Development

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Pediatric Hypertension

Part of the book series: Clinical Hypertension and Vascular Diseases ((CHVD))

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Abstract

Cardiovascular homeostasis is mediated through interacting neural, hormonal, and metabolic mechanisms that act both locally and systemically. These basic physiological mechanisms, which have been extensively studied in the adult, are functional in the fetus and newborn, although differential rates of maturation of these systems influence their ability to maintain blood pressure and delivery of oxygen and nutrients. This chapter focuses primarily on autonomic control of the fetal and newborn cardiovascular system and how hormonal and/or endocrine factors influence these systems.

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References

  1. Spyer KM. Central nervous mechanisms contributing to cardiovascular control. J Physiol. 1994;474:1–19.

    PubMed  CAS  Google Scholar 

  2. Tabsh K, Nuwayhid B, Ushioda E, Erkkola R, Brinkman CR, Assali NS. Circulatory effects of chemical sympathectomy in fetal, neonatal and adult sheep. Am J Physiol. 1982;243:H113–H122.

    PubMed  CAS  Google Scholar 

  3. Vapaavouri EK, Shinebourne EA, Williams RL, Heymann MA, Rudolph AM. Development of cardiovascular responses to autonomic blockade in intact fetal and neonatal lambs. Biol Neonate. 1973;22:177–188.

    Article  PubMed  CAS  Google Scholar 

  4. Walker AM, Cannata J, Dowling MH, Ritchie B, Maloney JE. Sympathetic and parasympathetic control of heart rate in unanaesthetized fetal and newborn lambs. Biol Neonate. 1978;33:135–143.

    Article  PubMed  CAS  Google Scholar 

  5. Nuwayhid B, Brinkman CR, Bevan JA, Assali NS. Development of autonomic control of fetal circulation. Am J Physiol. 1975;228:237–344.

    Google Scholar 

  6. Woods JR, Dandavino A, Murayama K, Brinkman CR, Assali NS. Autonomic control of cardiovascular functions during neonatal development and in adult sheep. Circ Res. 1977;40:401–407.

    PubMed  CAS  Google Scholar 

  7. Alper RH, Jacob JH, Brody MJ. Regulation of arterial pressure lability in rats with chronic sinoaortic deafferentation. Am J Physiol. 1987;253:H466–H474.

    PubMed  CAS  Google Scholar 

  8. Barres C, Lewis SJ, Jacob HJ, Brody MJ. Arterial pressure lability and renal sympathetic nerve activity are disassociated in SAD rats. Am J Physiol. 1992;263:R639–R646.

    PubMed  CAS  Google Scholar 

  9. Segar JL, Merrill DC, Smith BA, Robillard JE. Role of sympathetic activity in the generation of heart rate and arterial pressure variability in fetal sheep. Pediatr Res. 1994;35:250–254.

    Article  PubMed  CAS  Google Scholar 

  10. Yardly RW, Bowes G, Wilkinson M, et al. Increased arterial pressure variability after arterial baroreceptor denervation in fetal lambs. Circ Res. 1983;52:580–588.

    Google Scholar 

  11. Robillard JE, Nakamura KT, DiBona GF. Effects of renal denervation on renal responses to hypoxemia in fetal lambs. Am J Physiol. 1986;250(2 Pt 2):F294–F301.

    PubMed  CAS  Google Scholar 

  12. Clapp JF, Szeto HH, Abrams R, Mann LI. Physiologic variability and fetal electrocortical activity. Am J Obstet Gynecol. 1980;136:1045–1050.

    PubMed  Google Scholar 

  13. Mann LI, Duchin S, Weiss RR. Fetal EEG sleep stages and physiologic variability. Am J Obstet Gynecol. 1974;119:533–538.

    PubMed  CAS  Google Scholar 

  14. Reid DL, Jensen A, Phernetton TM, Rankin JHG. Relationship between plasma catecholamine levels and electrocortical state in the mature fetal lamb. J Dev Physiol. 1990;13:75–79.

    PubMed  CAS  Google Scholar 

  15. Wakatsuki A, Murata Y, Ninomoya Y, Masaoka N, Tyner JG, Kutty KK. Physiologic baroreceptor activity in the fetal lamb. Am J Obstet Gynecol. 1992;167:820–827.

    PubMed  CAS  Google Scholar 

  16. Jensen A, Bamford OS, Dawes GS, Hofmeyr G, Parkes MJ. Changes in organ blood flow between high and low voltage electrocortical activity in fetal sheep. J Dev Physiol. 1986;8:187–194.

    PubMed  CAS  Google Scholar 

  17. Richardson BS, Patrick JE, Abduljabbar H. Cerebral oxidative metabolism in the fetal lamb: relationship to electrocortical state. Am J Obstet Gynecol. 1985;153:426–431.

    PubMed  CAS  Google Scholar 

  18. Abboud F, Thames M. Interaction of cardiovascular reflexes in circulatory control. In: Shepherd JT, Abboud FM, eds. Handbook of Physiology, Section 2, Vol III, Part 2. Bethesda, MD: American Physiological Society; 1983:675–753.

    Google Scholar 

  19. Persson PB, Ehmke H, Kirchheim HR. Cardiopulmonary-arterial baroreceptor interaction in control of blood pressure. NIPS. 1989;4:56–59.

    Google Scholar 

  20. Yu ZY, Lumbers ER. Measurement of baroreceptor-mediated effects on heart rate variability in fetal sheep. Pediatr Res. 2000;47:233–239.

    Article  PubMed  CAS  Google Scholar 

  21. Brinkman CRI, Ladner C, Weston P, Assali NS. Baroreceptor functions in the fetal lamb. Am J Physiol. 1969;217:1346–1351.

    PubMed  Google Scholar 

  22. Itskovitz J, LaGamma EF, Rudolph AM. Baroreflex control of the circulation in chronically instrumented fetal lambs. Circ Res. 1983;52:589–596.

    PubMed  CAS  Google Scholar 

  23. Biscoe TJ, Purves MJ, Sampson SR. Types of nervous activity which may be recorded from the carotid sinus nerve in the sheep foetus. J Physiol. 1969;202:1–23.

    PubMed  CAS  Google Scholar 

  24. Blanco CE, Dawes GS, Hanson MA, McCooke HB. Carotid baroreceptors in fetal and newborn sheep. Pediatr Res. 1988;24:342–346.

    PubMed  CAS  Google Scholar 

  25. Downing SE. Baroreceptor reflexes in new-born rabbits. J Physiol. 1960; 150:201–213.

    PubMed  CAS  Google Scholar 

  26. Ponte J, Purves MJ. Types of afferent nervous activity which may be measured in the vagus nerve of the sheep foetus. J Physiol. 1973;229:51–76.

    PubMed  CAS  Google Scholar 

  27. Tomomatsu E, Nishi K. Comparison of carotid sinus baroreceptor sensitivity in newborn and adult rabbits. Am J Physiol. 1982;243:H546–H550.

    PubMed  CAS  Google Scholar 

  28. Andresen MC. Short and long-term determinants of baroreceptor function in aged normotensive and spontaneously hypertensive rats. Circ Res. 1984;54:750–759.

    PubMed  CAS  Google Scholar 

  29. Chapleau MW, Hajduczok G, Abboud FM. Mechanisms of resetting of arterial baroreceptors: an overview. Am J Med Sci. 1988;295:327–334.

    Article  PubMed  CAS  Google Scholar 

  30. Chapleau MW, Hajduczok G, Abboud FM. Resetting of the arterial baroreflex: peripheral and central mechanisms. In: Zucker IH, Gilmore JP, eds. Reflex Control of the Circulation. Boca Raton, FL: CRC Press; 1991:165–194.

    Google Scholar 

  31. Heesch CM, Abboud FM, Thames MD. Acute resetting of carotid sinus baroreceptors. II. Possible involvement of electrogenic Na+ pump. Am J Physiol. 1984;247:H833–H839.

    PubMed  CAS  Google Scholar 

  32. Jimbo M, Suzuki H, Ichikawa M, Kumagai K, Nishizawa M, Saruta T. Role of nitric oxide in regulation of baroreceptor reflex. J Auton Nerv Syst. 1994;50:209–219.

    Article  PubMed  CAS  Google Scholar 

  33. Matsuda T, Bates JN, Lewis SJ, Abboud FM, Chapleau MW. Modulation of baroreceptor activity by nitric oxide and S-nitrosocysteine. Circ Res. 1995;76(3):426–433.

    PubMed  CAS  Google Scholar 

  34. Bauer DJ. Vagal reflexes appearing in the rabbit at different ages. J Physiol. 1939;95:187–202.

    PubMed  CAS  Google Scholar 

  35. Dawes GS, Johnston BM, Walker DW. Relationship of arterial pressure and heart rate in fetal, new-born and adult sheep. J Physiol. 1980;309:405–417.

    PubMed  CAS  Google Scholar 

  36. Shinebourne EA, Vapaavuori EK, Williams RL, Heymann MA, Rudolph AM. Development of baroreflex activity in unanesthetized fetal and neonatal lambs. Circ Res. 1972;31:710–718.

    PubMed  CAS  Google Scholar 

  37. Vatner SF, Manders WT. Depressed responsiveness of the carotid sinus reflex in conscious newborn animals. Am J Physiol. 1979;237:H40–H43.

    PubMed  CAS  Google Scholar 

  38. Young M. Responses of the systemic circulation of the new-born infant. Br Med Bull. 1966;22:70–72.

    PubMed  CAS  Google Scholar 

  39. Booth LC, Malpas SC, Barrett CJ, Guild SJ, Gunn AJ, Bennet L. Is baroreflex control of sympathetic activity and heart rate active in the preterm fetal sheep? Am J Physiol Regul Integr Comp Physiol. 2009;296(3):R603–R609.

    Article  PubMed  CAS  Google Scholar 

  40. O’Connor SJ, Ousey JC, Gardner DS, Fowden AL, Giussani DA. Development of baroreflex function and hind limb vascular reactivity in the horse fetus. J Physiol. 2006;572(Pt 1):155–164.

    PubMed  Google Scholar 

  41. Segar JL, Hajduczok G, Smith BA, Robillard JE. Ontogeny of baroreflex control of renal sympathetic nerve activity and heart rate. Am J Physiol. 1992;263:H1819–H1826.

    PubMed  CAS  Google Scholar 

  42. Buckley NM, Gootman PM, Gootman GD, Reddy LC, Weaver LC, Crane LA. Age-dependent cardiovascular effects of afferent stimulation in neonatal pigs. Biol Neonate. 1976;30:268–279.

    Article  Google Scholar 

  43. Gootman PM. Developmental aspects of reflex control of the circulation. In: Zucker IH, Gilmore JP, eds. Reflex Control of the Circulation. Boca Raton, FL: CRC Press; 1991:965–1027.

    Google Scholar 

  44. Hajduczok G, Chapleau MW, Johnson SL, Abboud FM. Increase in sympathetic activity with age. I. Role of impairment of arterial baroreflexes. Am J Physiol. 1991;260:H1113–H1120.

    PubMed  CAS  Google Scholar 

  45. Segar JL, Mazursky JE, Robillard JE. Changes in ovine renal sympathetic nerve activity and baroreflex function at birth. Am J Physiol. 1994;267:H1824–H1832.

    PubMed  CAS  Google Scholar 

  46. Bishop VS, Haywood JR. Hormonal control of cardiovascular reflexes. In: Zucker IH, Gilmore JP, eds. Reflex Control of the Circulation. Boca Raton, FL: CRC Press; 1991:253–271.

    Google Scholar 

  47. Picton-Warlow CG, Mayer FE. Cardiovascular responses to postural changes in the neonate. Arch Dis Child. 1970;45:354–359.

    Article  PubMed  CAS  Google Scholar 

  48. Thoresen M, Cowan F, Walløe L. Cardiovascular responses to tilting in healthy newborn babies. Early Hum Dev. 1991;26:213–222.

    Article  PubMed  CAS  Google Scholar 

  49. Waldman S, Krauss AN, Auld PAM. Baroreceptors in preterm infants: their relationship to maturity and disease. Dev Med Child Neurol. 1979;21:714–722.

    Article  PubMed  CAS  Google Scholar 

  50. Myers MM, Gomez-Gribben E, Smith KS, Tseng A, Fifer WP. Developmental changes in infant heart rate responses to head-up tilting. Acta Paediatr. Jan 2006;95(1):77–81.

    Article  PubMed  Google Scholar 

  51. Fifer WP, Greene M, Hurtado A, Myers MM. Cardiorespiratory responses to bidirectional tilts in infants. Early Hum Dev. Jul 1999;55(3):265–279.

    Article  PubMed  CAS  Google Scholar 

  52. Gournay V, Drouin E, Roze JC. Development of baroreflex control of heart rate in preterm and full term infants. Arch Dis Child Fetal Neonatal Ed. May 2002;86(3):F151–F154.

    Article  PubMed  CAS  Google Scholar 

  53. Andriessen P, Oetomo SB, Peters C, Vermeulen B, Wijn PF, Blanco CE. Baroreceptor reflex sensitivity in human neonates: the effect of postmenstrual age. J Physiol. Oct 1 2005;568(Pt 1):333–341.

    Article  PubMed  CAS  Google Scholar 

  54. Chatow U, Davidson S, Reichman BL, Akselrod S. Development and maturation of the autonomic nervous system in premature and full-term infants using spectral analysis of heart rate fluctuations. Pediatr Res. 1995;37:294–302.

    Article  PubMed  CAS  Google Scholar 

  55. Clairambault J, Curzi-Dascalova L, Kauffmann F, Médigue C, Leffler C. Heart rate variability in normal sleeping full-term and preterm neonates. Early Human Dev. 1992;28:169–183.

    Article  CAS  Google Scholar 

  56. David M, Hirsch M, Karin J, Toledo E, Akselrod S. An estimate of fetal autonomic state by time-frequency analysis of fetal heart rate variability. J Appl Physiol. Mar 2007;102(3):1057–1064.

    Article  PubMed  Google Scholar 

  57. Karin J, Hirsch M, Akselrod S. An estimate of fetal autonomic state by spectral analysis of fetal heart rate fluctuations. Pediatr Res. Aug 1993;34(2):134–138.

    Article  PubMed  CAS  Google Scholar 

  58. Schneider U, Schleussner E, Fiedler A, et al. Fetal heart rate variability reveals differential dynamics in the intrauterine development of the sympathetic and parasympathetic branches of the autonomic nervous system. Physiol Meas. Feb 2009;30(2):215–226.

    Article  PubMed  CAS  Google Scholar 

  59. Mazursky JE, Birkett CL, Bedell KA, Ben-Haim SA, Segar JL. Development of baroreflex influences on heart rate variability in preterm infants. Early Hum Dev. 1998;53:37–52.

    Article  PubMed  CAS  Google Scholar 

  60. Minisi AJ, Thames MD. Reflexes from ventricular receptors with vagal afferents. In: Zucker IH, Gilmore JP, eds. Reflex Control of the Circulation. Boca Raton, FL: CRC Press; 1991:359.

    Google Scholar 

  61. Goetz KL, Madwed JB, Leadley RJJ. Atrial receptors: reflex effects in quadripeds. In: Zucker IH, Gilmore JP, eds. Reflex Control of the Circulation. Boca Raton, FL: CRC Press; 1991:291.

    Google Scholar 

  62. Hainsworth R. Reflexes from the heart. Physiol Rev. 1991;71:617–658.

    PubMed  CAS  Google Scholar 

  63. Togashi H, Yoshioka M, Tochihara M, Matsumoto M, Saito H. Differential effects of hemorrhage on adrenal and renal nerve activity in anesthetized rats. Am J Physiol. 1990;259:H1134–H1141.

    PubMed  CAS  Google Scholar 

  64. Victor RG, Thoren PN, Morgan DA, Mark AL. Differential control of adrenal and renal sympathetic nerve activity during hemorrhagic hypertension in rats. Circ Res. 1989;64:686–694.

    PubMed  CAS  Google Scholar 

  65. Baker DG, Coleridge HM, Coleridge JCG. Vagal afferent C fibers from the ventricle. In: Hainsworth R, Kidd C, Linden RJ, eds. Cardiac Receptors. Cambridge: Cambridge University Press; 1979:117.

    Google Scholar 

  66. Gupta BN, Thames MD. Behavior of left ventricular mechanoreceptors with myelinated and nonmyelinated afferent vagal fibers in cats. Circ Res. 1983;52:291–301.

    PubMed  CAS  Google Scholar 

  67. Thames MD, Donald SE, Shepherd JT. Stimulation of cardiac receptors with veratrum alkaloids inhibits ADH secretion. Am J Physiol. 1980;239:H784–H788.

    PubMed  CAS  Google Scholar 

  68. Assali NS, Brinkman CR, Wood R Jr, Danavino A, Nuwayhid B. Ontogenesis of the autonomic control of cardiovascular function in the sheep. In: Longo LD, Reneau DD, eds. Fetal and Newborn Cardiovascular Physiology. New York, NY: Garland STPM Press; 1978:47–91.

    Google Scholar 

  69. Gootman PM, Buckley BJ, DiRusso SM, et al. Age-related responses to stimulation of cardiopulmonary receptors in swine. Am J Physiol. 1986;251:H748–H755.

    PubMed  CAS  Google Scholar 

  70. Merrill DC, Segar JL, McWeeny OJ, Smith BA, Robillard JE. Cardiopulmonary and arterial baroreflex responses to acute volume expansion during fetal and postnatal development. Am J Physiol. 1994;267:H1467–H1475.

    PubMed  CAS  Google Scholar 

  71. Smith F, Klinkefus J, Robillard J. Effects on volume expansion on renal sympathetic nerve activity and cardiovascular and renal function in lambs. Am J Physiol. 1992;262:R651–R658.

    PubMed  CAS  Google Scholar 

  72. Merrill DC, McWeeny OJ, Segar JL, Robillard JE. Impairment of cardiopulmonary baroreflexes during the newborn period. Am J Physiol. 1995;268:H1343–H1351.

    Google Scholar 

  73. Gomez RA, Meernik JG, Kuehl WD, Robillard JE. Developmental aspects of the renal response to hemorrhage during fetal life. Pediatr Res. 1984;18:40–46.

    PubMed  CAS  Google Scholar 

  74. Chen H-G, Wood CE, Bell ME. Reflex control of fetal arterial pressure and hormonal responses to slow hemorrhage. Am J Physiol. 1992;262:H225–H233.

    PubMed  CAS  Google Scholar 

  75. Toubas PL, Silverman NH, Heymann MA, Rudolph AM. Cardiovascular effects of acute hemorrhage in fetal lambs. Am J Physiol. 1981;240:H45–H48.

    PubMed  CAS  Google Scholar 

  76. Wood CE, Chen H-G, Bell ME. Role of vagosympathetic fibers in the control of adrenocorticotropic hormone, vasopressin, and renin responses to hemorrhage in fetal sheep. Circ Res. 1989;64:515–523.

    PubMed  CAS  Google Scholar 

  77. O’Mara MS, Merrill DC, McWeeny OJ, Robillard JE. Ontogeny and regulation of arterial and cardiopulmonary baroreflex control of renal sympathetic nerve activity (RSNA) in response to hypotensive (NH) and hypotensive hemorrhage (HH) postnatally. Pediatr Res. 1995;37:31A.

    Google Scholar 

  78. Smith FG, Abu-Amarah I. Renal denervation alters cardiovascular and endocrine responses to hemorrhage in conscious newborn lambs. Am J Physiol. 1998;275:H285–H291.

    PubMed  CAS  Google Scholar 

  79. Merrill DC, Segar JL, McWeeny OJ, Robillard JE. Sympathetic responses to cardiopulmonary vagal afferent stimulation during development. Am J Physiol. 1999;277:H1311–H1316.

    PubMed  CAS  Google Scholar 

  80. Cornish KG, Barazanji MW, Yong T, Gilmore JP. Volume expansion attenuates baroreflex sensitivity in the conscious nonhuman primate. Am J Physiol. 1989;257:R595–R598.

    PubMed  CAS  Google Scholar 

  81. Hajduczok G, Chapleau MW, Abboud FM. Increase in sympathetic activity with age: II. Role of impairment of cardiopulmonary baroreflexes. Am J Physiol. 1991;260:H1121–H1127.

    PubMed  CAS  Google Scholar 

  82. Bishop VS, Hasser EM, Nair UC. Baroreflex control of renal nerve activity in conscious animals. Circ Res. 1987;61:I76–I81.

    PubMed  CAS  Google Scholar 

  83. Cohn HE, Sacks EJ, Heymann MA, Rudolph AM. Cardiovascular responses to hypoxemia and acidemia in fetal lambs. Am J Obstet Gynecol. 1974;120(6):817–824.

    PubMed  CAS  Google Scholar 

  84. Giussani DA, Spencer JAD, Moore PJ, Bennet L, Hanson MA. Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep. J Physiol. 1993;461:431–449.

    PubMed  CAS  Google Scholar 

  85. Gardner DS, Fletcher JW, Bloomfield MR, Fowden AL, Giussani DA. Effects of prevailing hypoxaemia, acidaemia or hypoglycaemia upon the cardiovascular, endocrine and metabolic responses to acute hypoxaemia in the ovine fetus. J Physiol. 2002;540:351–366.

    Article  PubMed  CAS  Google Scholar 

  86. Carroll JL, Kim I. Postnatal development of carotid body glomus cell O2 sensitivity. Respir Physiol Neurobiol. 2005;149(1–3):201–215.

    Article  PubMed  Google Scholar 

  87. Iwamota HS, Rudolph AM, Mirkin BL, Keil LC. Circulatory and humoral responses of sympathectomized fetal sheep to hypoxemia. Am J Physiol. 1983;245:H767–H772.

    Google Scholar 

  88. Bennet L, Rossenrode S, Gunning MI, Gluckman PD, Gunn AJ. The cardiovascular and cerebrovascular responses of the immature fetal sheep to acute umbilical cord occlusion. J Physiol. May 15 1999;517(Pt 1):247–257.

    Article  PubMed  CAS  Google Scholar 

  89. Iwamoto HS, Kaufman T, Keil LC, Rudolph AM. Responses to acute hypoxemia in fetal sheep at 0.6–0.7 gestation. Am J Physiol. Mar 1989;256(3 Pt 2):H613–H620.

    PubMed  CAS  Google Scholar 

  90. Szymonowicz W, Walker AM, Yu VY, Stewart ML, Cannata J, Cussen L. Regional cerebral blood flow after hemorrhagic hypotension in the preterm, near-term, and newborn lamb. Pediatr Res. Oct 1990;28(4):361–366.

    Article  PubMed  CAS  Google Scholar 

  91. Wassink G, Bennet L, Booth LC, et al. The ontogeny of hemodynamic responses to prolonged umbilical cord occlusion in fetal sheep. J Appl Physiol. Oct 2007;103(4):1311–1317.

    Article  PubMed  Google Scholar 

  92. Fletcher AJ, Gardner DS, Edwards CM, Fowden AL, Giussani DA. Development of the ovine fetal cardiovascular defense to hypoxemia towards full term. Am J Physiol Heart Circ Physiol. Dec 2006;291(6):H3023–H3034.

    Article  PubMed  CAS  Google Scholar 

  93. Hanson MA. Role of chemoreceptors in effects of chronic hypoxia. Comp Biochem Physiol. 1997;119A:695–703.

    Google Scholar 

  94. Thakor AS, Giussani DA. Effects of acute acidemia on the fetal cardiovascular defense to acute hypoxemia. Am J Physiol Regul Integr Comp Physiol. Jan 2009;296(1):R90–R99.

    Article  PubMed  CAS  Google Scholar 

  95. Ruijtenbeek K, LeNoble FA, Janssen GM, et al. Chronic hypoxia stimulates periarterial sympathetic nerve development in chicken embryo. Circulation. 2000;102:2892–2897.

    PubMed  CAS  Google Scholar 

  96. Hanson MA, Kumar P, Williams BA. The effect of chronic hypoxia upon the development of respiratory chemoreflexes in the newborn kitten. J Physiol. Apr 1989;411:563–574.

    PubMed  CAS  Google Scholar 

  97. Blanco CE, Dawes GS, Hanson MA, McCooke HB. The response to hypoxia of arterial chemoreceptors in fetal sheep and newborn lambs. J Physiol. 1984;351:25–37.

    PubMed  CAS  Google Scholar 

  98. Hertzberg T, Lagercrantz H. Postnatal sensitivity of the peripheral chemoreceptors in newborn infants. Arch Dis Child. 1987;62:1238–1241.

    Article  PubMed  CAS  Google Scholar 

  99. Kumar P, Hanson MA. Re-setting of the hypoxic sensitivity of aortic chemoreceptors in the new-born lamb. J Dev Physiol. 1989;11:199–206.

    PubMed  CAS  Google Scholar 

  100. Blanco CE, Hanson MA, McCooke HB. Effects on carotid chemoreceptor resetting of pulmonary ventilation in the fetal lamb in utero. J Dev Physiol. Apr 1988;10(2):167–174.

    PubMed  CAS  Google Scholar 

  101. Koos BJ, Chau A, Ogunyemi D. Adenosine mediates metabolic and cardiovascular responses to hypoxia in fetal sheep. J Physiol (Lond). 1995;488:761–766.

    CAS  Google Scholar 

  102. Koos BJ, Maeda T. Adenosine A2A receptors mediate cardiovascular responses to hypoxia in fetal sheep. Am J Physiol. 2001;280:H83–H89.

    CAS  Google Scholar 

  103. Hertzberg T, Hellstrom S, Holgert H, Lagercrantz H, Pequignot JM. Ventilatory response to hyperoxia in newborn rats born in hypoxia—possible relationship to carotid body dopamine. J Physiol. Oct 1992;456:645–654.

    PubMed  CAS  Google Scholar 

  104. Sterni LM, Bamford OS, Tomares SM, Montrose MH, Carroll JL. Developmental changes in intracellular Ca2+ response of carotid chemoreceptor cells to hypoxia. Am J Physiol. 1995;268:L801–L808.

    PubMed  CAS  Google Scholar 

  105. Dawes GS. Changes in the circulation at birth. Br Med Bull. 1961;17:148–153.

    PubMed  CAS  Google Scholar 

  106. Padbury JF, Martinez AM. Sympathoadrenal system activity at birth: integration of postnatal adaptation. Semin Perinatol. 1988;12:163–172.

    PubMed  CAS  Google Scholar 

  107. Lagercrantz H, Bistoletti P. Catecholamine release in the newborn at birth. Pediatr Res. 1973;11:889–893.

    Google Scholar 

  108. Padbury JF, Diakomanolis ES, Hobel CJ, Perlman A, Fisher DA. Neonatal adaptation: sympatho-adrenal response to umbilical cord cutting. Pediatr Res. 1981;15:1483–1487.

    Article  PubMed  CAS  Google Scholar 

  109. Minoura S, Gilbert RD. Postnatal changes of cardiac function in lambs: effects of ganglionic block and afterload. J Dev Physiol. 1986;9:123–135.

    Google Scholar 

  110. Hilton SM. The defense-arousal system and its relevance for circulatory and respiratory control. J Exp Biol. 1982;100:159–174.

    PubMed  CAS  Google Scholar 

  111. Ogundipe OA, Kullama LK, Stein H, et al. Fetal endocrine and renal responses to in utero ventilation and umbilical cord occlusion. Am J Obstet Gynecol. 1993;169:1479–1486.

    PubMed  CAS  Google Scholar 

  112. Smith FG, Smith BA, Segar JL, Robillard JE. Endocrine effects of ventilation, oxygenation and cord occlusion in near-term fetal sheep. J Dev Physiol. 1991;15:133–138.

    PubMed  CAS  Google Scholar 

  113. Mazursky JE, Segar JL, Nuyt A-M, Smith BA, Robillard JE. Regulation of renal sympathetic nerve activity at birth. Am J Physiol. 1996;270:R86–R93.

    PubMed  CAS  Google Scholar 

  114. Segar JL, Smith OJ, Holley AT. Mechano- and chemoreceptor modulation of renal sympathetic nerve activity at birth in fetal sheep. Am J Physiol. 1999;276:R1295–R1301.

    PubMed  CAS  Google Scholar 

  115. Gunn TR, Johnston BM, Iwamoto HS, Fraser M, Nicholls MG, Gluckman PD. Haemodynamic and catecholamine responses to hypothermia in the fetal sheep in utero. J Dev Physiol. 1985;7:241–249.

    PubMed  CAS  Google Scholar 

  116. Van Bel F, Roman C, Iwamoto HS, Rudolph AM. Sympathoadrenal, metabolic, and regional blood flow responses to cold in fetal sheep. Pediatr Res. 1993;34:47–50.

    Article  PubMed  Google Scholar 

  117. Gunn TR, Ball KT, Power GG, Gluckman PD. Factors influencing the initiation of nonshivering thermogenesis. Am J Obstet Gynecol. 1991;164:210–217.

    PubMed  CAS  Google Scholar 

  118. Calaresu FR, Yardley CP. Medullary basal sympathetic tone. Ann Rev Physiol. 1988;50:511–524.

    Article  CAS  Google Scholar 

  119. Gebber GL. Central determinants of sympathetic nerve discharge. In: Loewy AD, Spyer KM, eds. Central Regulation of Autonomic Function. New York, NY: Oxford University Press; 1990:126–144.

    Google Scholar 

  120. Strack AM, Sawyer WB, Platt KB, Loewy AD. CNS cell groups regulating the sympathetic outflow to adrenal gland as revealed by transneuronal cell body labeling with pseudorabies virus. Brain Res. Jul 10 1989;491(2):274–296.

    Article  PubMed  CAS  Google Scholar 

  121. Swanson LW, Sawchenko PE. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu Rev Neurosci. 1983;6:269–324.

    Article  PubMed  CAS  Google Scholar 

  122. Williams RL, Hof RP, Heymann MA, Rudolph AM. Cardiovascular effects of electrical stimulation of the forebrain in the fetal lamb. Pediatr Res. 1976;10:40–45.

    Article  PubMed  CAS  Google Scholar 

  123. Segar JL, Ellsbury DL, Smith OM. Inhibition of sympathetic responses at birth in sheep by lesion of the paraventricular nucleus. Am J Physiol. 2002;283:R1395–R1403.

    CAS  Google Scholar 

  124. Segar JL, Lumbers ER, Nuyt AM, Smith OJ, Robillard JE. Effect of antenatal glucocorticoids on sympathetic nerve activity at birth in preterm sheep. Am J Physiol. 1998;274:R160–R167.

    PubMed  CAS  Google Scholar 

  125. Segar JL, Bedell KA, Smith OJ. Glucocorticoid modulation of cardiovascular and autonomic function in preterm lambs: role of ANG II. Am J Physiol. 2001;280:R646–R654.

    CAS  Google Scholar 

  126. Guillery EN, Robillard JE. The renin-angiotensin system and blood pressure regulation during infancy and childhood. In: Rocchini AP, ed. The Pediatric Clinics of North America: Childhood Hypertension. Philadelphia, PA: W.B. Saunders; 1993:61–77.

    Google Scholar 

  127. Iwamota HS, Rudolph AM. Effects of endogenous angiotensin II on the fetal circulation. J Dev Physiol. 1979;1:283–293.

    Google Scholar 

  128. Lumbers ER. Functions of the renin-angiotensin system during development. Clin Exp Pharmacol Physiol. 1995;22:499–505.

    Article  PubMed  CAS  Google Scholar 

  129. Kim S, Iwao H. Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev. 2001;52:11–34.

    Google Scholar 

  130. Robillard JE, Weismann DN, Gomez RA, Ayres NA, Lawton WJ, VanOrden DE. Renal and adrenal responses to converting-enzyme inhibition in fetal and newborn life. Am J Physiol. 1983;244:R249–R256.

    PubMed  CAS  Google Scholar 

  131. Scroop GC, Stankewytsch-Janusch B, Marker JD. Renin-angiotensin and automatic mechanisms in cardiovascular homeostasis during hemorrhage in fetal and neonatal sheep. J Dev Physiol. 1992;18:25–33.

    PubMed  CAS  Google Scholar 

  132. Weismann DN, Herrig JE, McWeeny OJ, Ayres NA, Robillard JE. Renal and adrenal responses to hypoxemia during angiotensin-converting enzyme inhibition in lambs. Circ Res. 1983;52:179–187.

    PubMed  CAS  Google Scholar 

  133. Bartunek J, Weinberg EO, Tajima M, Rohrbach S, Lorell BH. Angiotensin II type 2 receptor blockade amplifies the early signals of cardiac growth response to angiotensin II in hypertrophied hearts. Circulation. 1999;99:22–25.

    PubMed  CAS  Google Scholar 

  134. Stalker HB, Holland NH, Kotchen JM, Kotchen TA. Plasma renin activity in healthy children. J Pediatr. 1976;89:256–258.

    Article  PubMed  CAS  Google Scholar 

  135. Richer C, Hornych H, Amiel-Tison C, Relier JP, Giudicelli JF. Plasma renin activity and its postnatal development in preterm infants. Preliminary report. Biol Neonate. 1977;31:301–304.

    Article  PubMed  CAS  Google Scholar 

  136. Robillard JE, Weitzman RE. Developmental aspects of the fetal renal response to exogenous arginine vasopressin. Am J Physiol. 1980;238:F407–F414.

    PubMed  CAS  Google Scholar 

  137. Robillard JE, Gomez RA, VanOrden D, Smith FG Jr. Comparison of the adrenal and renal responses to angiotensin II in fetal lambs and adult sheep. Circ Res. 1982;50:140–147.

    PubMed  CAS  Google Scholar 

  138. Wood CE. Baroreflex and chemoreflex control of fetal hormone secretion. Reprod, Fertil Dev. 1995;7:479–489.

    Article  CAS  Google Scholar 

  139. Jones III OW, Cheung CY, Brace RA. Dose-dependent effects of angiotensin II on the ovine fetal cardiovascular system. Am J Obstet Gynecol. 1991;165:1524–1533.

    Google Scholar 

  140. Ismay MJ, Lumbers ER, Stevens AD. The action of angiotensin II on the baroreflex response of the conscious ewe and the conscious fetus. J Physiol. 1979;288:467–479.

    PubMed  CAS  Google Scholar 

  141. Scroop GC, Marker JD, Stankewytsch B, Seamark RF. Angiotensin I and II in the assessment of baroreceptor function in fetal and neonatal sheep. J Dev Physiol. 1986;8:123–137.

    PubMed  CAS  Google Scholar 

  142. Segar JL, Merrill DC, Smith BA, Robillard JE. Role of endogenous angiotensin II on resetting of the arterial baroreflex during development. Am J Physiol. 1994;266:H52–H59.

    PubMed  CAS  Google Scholar 

  143. Reid IA. Interactions between ANG II, sympathetic nervous system and baroreceptor reflex in regulation of blood pressure. Am J Physiol. 1992;262:E763–E778.

    PubMed  CAS  Google Scholar 

  144. Bunnemann B, Fuxe K, Ganten D. The renin-angiotensin system in the brain: an update 1993. Regul Pept. 1993;46:487–509.

    Article  PubMed  CAS  Google Scholar 

  145. Head GA, Mayorov DN. Central angiotensin and baroreceptor control of circulation. Ann N Y Acad Sci. 2001;940:361–379.

    Article  PubMed  CAS  Google Scholar 

  146. Toney GM, Porter JP. Effects of blockade of AT1 and AT2 receptors in brain on the central angiotensin II pressor response in conscious spontaneously hypertensive rats. Neuropharmacology. 1993;32:581–589.

    Article  PubMed  CAS  Google Scholar 

  147. Shi L, Mao C, Thornton SN, et al. Effects of intracerebroventricular losartan on angiotensin II-mediated pressor responses and c-fos expression in near-term ovine fetus. J Comp Neurol. Dec 26 2005;493(4):571–579.

    Article  PubMed  CAS  Google Scholar 

  148. Xu Z, Shi L, Hu F, White R, Stewart L, Yao J. In utero development of central ANG-stimulated pressor response and hypothalamic fos expression. Brain Res Dev Brain Res. Nov 12 2003;145(2):169–176.

    Article  PubMed  CAS  Google Scholar 

  149. Xu Z, Shi L, Yao J. Central angiotensin II-induced pressor responses and neural activity in utero and hypothalamic angiotensin receptors in preterm ovine fetus. Am J Physiol Heart Circ Physiol. Apr 2004;286(4):H1507–H1514.

    Article  PubMed  CAS  Google Scholar 

  150. Segar JL, Minnick A, Nuyt AM, Robillard JE. Role of endogenous ANG II and AT1 receptors in regulating arterial baroreflex responses in newborn lambs. Am J Physiol. 1997;272:R1862–R1873.

    PubMed  CAS  Google Scholar 

  151. Robillard JE, Weitzman RE, Fisher DA, Smith FG Jr. The dynamics of vasopressin release and blood volume regulation during fetal hemorrhage in the lamb fetus. Pediatr Res. 1979;13:606–610.

    PubMed  CAS  Google Scholar 

  152. Weitzman RE, Fisher DA, Robillard J, Erenberg A, Kennedy R, Smith F. Arginine vasopressin response to an osmotic stimulus in the fetal sheep. Pediatr Res. 1978;12:35–38.

    Article  PubMed  CAS  Google Scholar 

  153. Wood CE, Chen HG. Acidemia stimulates ACTH, vasopressin, and heart rate responses in fetal sheep. Am J Physiol. 1989;257:R344–R349.

    PubMed  CAS  Google Scholar 

  154. Giussani DA, McGarrigle HHG, Spencer JAD, Moore PJ, Bennet L, Hanson MA. Effect of carotid denervation on plasma vasopressin levels during acute hypoxia in the late-gestation sheep fetus. J Physiol. 1994;477:81–87.

    PubMed  CAS  Google Scholar 

  155. Raff H, Kane CW, Wood CE. Arginine vasopressin responses to hypoxia and hypercapnia in late-gestation fetal sheep. Am J Physiol. 1991;260:R1077–R1081.

    PubMed  CAS  Google Scholar 

  156. Irion GL, Mack CE, Clark KE. Fetal hemodynamic and fetoplacental vasopressin response to exogenous arginine vasopressin. Am J Obstet Gynecol. 1990;162:115–120.

    Google Scholar 

  157. Tomita H, Brace RA, Cheung CY, Longo LD. Vasopressin dose-response effects on fetal vascular pressures, heart rate, and blood volume. Am J Physiol. 1985;249:H974–H980.

    PubMed  CAS  Google Scholar 

  158. Ervin MG, Ross MG, Leake RD, Fisher DA. V1 and V2-receptor contributions to ovine fetal renal and cardiovascular responses to vasopressin. Am J Physiol. 1992;262:R636–R643.

    PubMed  CAS  Google Scholar 

  159. Nuyt A-M, Segar JL, Holley AT, O’Mara MS, Chapleau MW, Robillard JE. Arginine vasopressin modulation of arterial baroreflex responses in fetal and newborn sheep. Am J Physiol. 1996;271:R1643–R1653.

    PubMed  CAS  Google Scholar 

  160. Kelly RT, Rose JC, Meis PJ, Hargrave BY, Morris M. Vasopressin is important for restoring cardiovascular homeostasis in fetal lambs subjected to hemorrhage. Am J Obstet Gynecol. 1983;146:807–812.

    PubMed  CAS  Google Scholar 

  161. Berecek KH, Swords BH. Central role for vasopressin in cardiovascular regulation and the pathogenesis of hypertension. Hypertension. 1990;16:213–224.

    PubMed  CAS  Google Scholar 

  162. Luk J, Ajaelo I, Wong V, et al. Role of V1 receptors in the action of vasopressin on the baroreflex control of heart rate. Am J Physiol. 1993;265:R524–R529.

    PubMed  CAS  Google Scholar 

  163. Stark RI, Daniel SS, Husain MK, Tropper PJ, James LS. Cerebrospinal fluid and plasma vasopressin in the fetal lamb: basal concentration and the effect of hypoxia. Endocrinology. 1985;116:65–72.

    Article  PubMed  CAS  Google Scholar 

  164. Segar JL, Minnick A, Nuyt A-M, Robillard JE. Developmental changes in central vasopressin regulation of cardiovascular function. Pediatr Res. 1995;37:34A.

    Article  Google Scholar 

  165. Unger T, Rohmeiss P, Demmert G, Ganten D, Lang RE, Luft F. Opposing cardiovascular effects of brain and plasma AVP: role of V1- and V2-AVP receptors. In: Buckley JP, Ferrario CM, eds. Brain Peptides and Catecholamines in Cardiovascular Regulation. New York, NY: Raven Press; 1987:393–401.

    Google Scholar 

  166. Tangalakis T, Lumbers ER, Moritz KM, Towstoless MK, Wintour EM. Effect of cortisol on blood pressure and vascular reactivity in the ovine fetus. Exp Physiol. 1992;77:709–717.

    PubMed  CAS  Google Scholar 

  167. Unno N, Wong CH, Jenkins SL, et al. Blood pressure and heart rate in the ovine fetus: ontogenic changes and effects of fetal adrenalectomy. Am J Physiol. 1999;276:H248–H256.

    PubMed  CAS  Google Scholar 

  168. Derks JB, Giussani DA, Jenkins SL, et al. A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol. 1997;499:217–226.

    PubMed  CAS  Google Scholar 

  169. Padbury JF, Polk DH, Ervin G, Berry LM, Ikegami M, Jobe AH. Postnatal cardiovascular and metabolic responses to a single intramuscular dose of betamethasone in fetal sheep born prematurely by cesarean section. Pediatr Res. 1995;38:709–715.

    Article  PubMed  CAS  Google Scholar 

  170. Stein HM, Oyama K, Martinez A, et al. Effects of corticosteroids in preterm sheep on adaptation and sympathoadrenal mechanisms at birth. Am J Physiol. 1993;264:E763–E769.

    PubMed  CAS  Google Scholar 

  171. Ng PC, Lee CH, Bnur FL, et al. A double-blind, randomized, controlled study of a "stress dose" of hydrocortisone for rescue treatment of refractory hypotension in preterm infants. Pediatrics. Feb 2006;117(2):367–375.

    Article  PubMed  Google Scholar 

  172. Seri I, Tan R, Evans J. Cardiovascular effects of hydrocortisone in preterm infants with pressor-resistant hypotension. Pediatrics. May 2001;107(5):1070–1074.

    Article  PubMed  CAS  Google Scholar 

  173. Dodt C, Keyser B, Molle M, Fehm HL, Elam M. Acute suppression of muscle sympathetic nerve activity by hydrocortisone in humans. Hypertension. 2000;35:758–763.

    PubMed  CAS  Google Scholar 

  174. Macefield VG, Williamson PM, Wilson LR, Kelly JJ, Gandevia SC, Whitworth JA. Muscle sympathetic vasoconstrictor activity in hydrocortisone-induced hypertension in humans. Blood Press. 1998;7: 215–222.

    Article  PubMed  CAS  Google Scholar 

  175. Grünfeld JP, Eloy L. Glucocorticoids modulate vascular reactivity in the rat. Hypertension. 1987;10: 608–618.

    PubMed  Google Scholar 

  176. Grünfled JP. Glucocorticoids in blood pressure regulation. Horm Res. 1990;34:111–113.

    Article  Google Scholar 

  177. Provencher PH, Saltis J, Funder JW. Glucocorticoids but not mineralocorticoids modulate endothelin-1 and angiotensin II binding in SHR vascular smooth muscle cells. J Steroid Biochem Mol Biol. 1995;52:219–225.

    Article  PubMed  CAS  Google Scholar 

  178. Sato A, Suzuki H, Iwaita Y, Nakazato Y, Kato H, Saruta T. Potentiation of inositol trisphosphate production by dexamethasone. Hypertension. 1992;19:109–115.

    PubMed  CAS  Google Scholar 

  179. Wallerath T, Witte K, Schäfer SC, et al. Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension. PNAS. 1999;96:13357–13362.

    Article  PubMed  CAS  Google Scholar 

  180. Fletcher AJW, McGarrigle HHG, Edwards CMB, Fowden AL. Effects of low dose dexamethasone treatment on basal cardiovascular and endocrine function in fetal sheep during late gestation. J Physiol. 2002;545:649–660.

    Article  PubMed  CAS  Google Scholar 

  181. Anwar MA, Schwab M, Poston L, Nathanielsz PW. Betamethasone-mediated vascular dysfunction and changes in hematological profile in the ovine fetus. Am J Physiol. 1999;276:H1137–H1143.

    PubMed  CAS  Google Scholar 

  182. Docherty CC, Kalmar-Nagy J. Development of fetal vascular responses to endothelin-1 and acetylcholine in the sheep. Am J Physiol. 2001;280:R554–R562.

    CAS  Google Scholar 

  183. Docherty CC, Kalmar-Nagy J, Engelen M, et al. Effect of in vivo fetal infusion of dexamethasone at 0.75 GA on fetal ovine resistance artery responses to ET-1. Am J Physiol. 2001;281:R261–R268.

    CAS  Google Scholar 

  184. Molnar J, Nijland M, Howe DC, Nathanelsz PW. Evidence for microvascular dysfunction after prenatal dexamethasone at 0.7, 0.75, and 0.8 gestation in sheep. Am J Physiol. 2002;283:R561–R567.

    CAS  Google Scholar 

  185. Ervin MG, Padbury JF, Polk DH, Ikegami M, Berry LM, Jobe AH. Antenatal glucocorticoids alter premature newborn lamb neuroendocrine and endocrine responses to hypoxia. Am J Physiol. 2000;279:R830–R838.

    CAS  Google Scholar 

  186. Fletcher AJ, Gardner DG, Edwards CMB, Fowden AL, Giussani DA. Cardiovascular and endocrine responses to acute hypoxaemia during and following dexamethasone infusion in the ovine fetus. J Physiol. 2003;15:283–291.

    Google Scholar 

  187. Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol. 2000;88:1474–1480.

    PubMed  CAS  Google Scholar 

  188. Slotkin TA, Lappi SE, McCook EC, Tayyeb MI, Eylers JP, Seidler FJ. Glucocorticoids and the development of neuronal function: effects of prenatal dexamethasone exposure on central noradrenergic activity. Biol Neonate. 1992;61:326–336.

    Article  PubMed  CAS  Google Scholar 

  189. Segar JL, Van Natta T, Smith OJ. Effects of fetal ovine adrenalectomy on sympathetic and baroreflex responses at birth. Am J Physiol. 2002;283:R460–R467.

    CAS  Google Scholar 

  190. Chlorakos A, Langille BL, Adamson SL. Cardiovascular responses attenuate with repeated NO synthesis inhibition in conscious fetal sheep. Am J Physiol. 1998;274:H1472–H1480.

    PubMed  CAS  Google Scholar 

  191. Sanhueza EM, Riquelme RA, Herrera EA, et al. Vasodilator tone in the llama fetus: the role of nitric oxide during normoxemia and hypoxemia. Am J Physiol Regul Integr Comp Physiol. Sep 2005;289(3): R776–R783.

    Article  PubMed  CAS  Google Scholar 

  192. Yu ZY, Lumbers ER, Simonetta G. The cardiovascular and renal effects of acute and chronic inhibition of nitric oxide production in fetal sheep. Exp Physiol. 2002;87:343–351.

    Article  PubMed  CAS  Google Scholar 

  193. Ma SX, Fang Q, Morgan B, Ross MG, Chao CR. Cardiovascular regulation and expressions of NO synthase-tyrosine hydroxylase in nucleus tractus solitarius of ovine fetus. Am J Physiol Heart Circ Physiol. Apr 2003;284(4):H1057–H1063.

    PubMed  CAS  Google Scholar 

  194. McDonald TJ, Le WW, Hoffman GE. Brainstem catecholaminergic neurons activated by hypoxemia express GR and are coordinately activated with fetal sheep hypothalamic paraventricular CRH neurons. Brain Res. 2000;885:70–78.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Pediatrics, Division of Neonatology, University of Iowa Carver College of Medicine, Iowa City, IA, USA

    Jeffrey L. Segar MD

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  1. , Division of Nephrology, Seattle Children's Hospital, Sand Point Way NE. 4800, Seattle, 98105, Washington, USA

    Joseph T. Flynn

  2. Massachusetts General Hospital, Fruit St. 55, Boston, 02114, Massachusetts, USA

    Julie R. Ingelfinger

  3. Global Clinical Research, Bristol-Myers Squibb, Route 206 & Provinceline Road, Princeton, 08543, New Jersey, USA

    Ronald J. Portman

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Segar, J.L. (2011). Neurohumoral Regulation of Blood Pressure in Early Development. In: Flynn, J., Ingelfinger, J., Portman, R. (eds) Pediatric Hypertension. Clinical Hypertension and Vascular Diseases. Humana Press. https://doi.org/10.1007/978-1-60327-824-9_1

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