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Embryonic Stem Cells, Cardiomyoplasty, and the Risk of Teratoma Formation

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Trends in Stem Cell Biology and Technology

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Abstract

Embryonic, fetal, and adult stem cells have been extensively tested in the past decade as candidates for cell replacement therapy of severe heart failure. Among them, embryonic stem (ES) cells have been regarded as an especially valuable source of therapeutic cells due to their unlimited growth in culture and well-established cardiogenic potential in vitro. ES cell preparations that were tested in animal models of heart infarction ranged from fully undifferentiated and cardiac-committed ES cells to partially or highly enriched ES cell-derived cardiomyocytes. Here we critically review the current literature on use of fully undifferentiated ES cells for cardiac repair, elaborate on the tumorigenic risk of ES cells and pluripotent cells in general, and summarize strategies for elimination of this threat as an important step toward translation of ES cell-based therapies to clinic. This discussion is also highly relevant for clinical applicability of newly developed autologous ES cell-like stem cells, so-called induced pluripotent stem cells, which circumvent ethical and, to some extent, immunological concerns linked to the use of blastocyst-derived ES cells, but still possess high tumorigenic potential.

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Acknowledgments

This work was supported by grants from The German Research Society (DFG) to T.Š. (Grant SA 1382/2-1), The Federal Ministry of Education and Research (BMBF) to H.J. and T.Š. (Grant 01GN0541), and from Köln Fortune Program to T.Š. and L.P.F.

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  1. Medical Center, Institute for Neurophysiology, University of Cologne, Robert-Koch-Str. 39, 50931, Cologne, Germany

    Tomo Saric, Lukas P. Frenzel, Azra Fatima, Manoj K. Gupta & Jürgen Hescheler

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  1. Tomo Saric
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    Saric, T., Frenzel, L.P., Fatima, A., Gupta, M.K., Hescheler, J. (2009). Embryonic Stem Cells, Cardiomyoplasty, and the Risk of Teratoma Formation. In: Baharvand, H. (eds) Trends in Stem Cell Biology and Technology. Humana Press. https://doi.org/10.1007/978-1-60327-905-5_14

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