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Multifaceted Therapeutic Value of Roselle (Hibiscus sabdariffa L. – Malvaceae)

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References

  1. World Health Organization. Traditional medicine. Fact sheet N°134. www.who.org. Revised December 2008. Accessed 12 Jan 2010.

  2. Duke J, du Cellier J. CRC handbook of alternative cash crops. Boca Raton: CRC Press; 1993. p. 280–3.

    Google Scholar 

  3. Mabberley DJ. Mabberley’s plant book. 3rd ed. London: Cambridge University Press; 2008. p. 406.

    Google Scholar 

  4. Luján A. Flor de Jamaica orgánica de México (Hibiscus sabdariffa L.) 2005. http://vinculando.org/mercado/flor_jamaica.html. Accessed 23 Nov 2009.

  5. Wickens G. Economic botany. Dordrecht: Kluwer; 2001. p. 179. p. 188.

    Google Scholar 

  6. Ayensu E. Medicinal plants of the West Indies. Algonac: Reference Publications; 1981. p. 120.

    Google Scholar 

  7. Davidow J. Infusions of healing: A treasury of Mexican-American herbal remedies. New York: Fireside; 1999. p. 135–6.

    Google Scholar 

  8. Ford K. Las Yerbas de la Gente: A study of Hispano-American medicinal plants. Ann Arbor: University of Michigan; 1978.

    Google Scholar 

  9. Ojeda D, Jiménez-Ferrer E, Zamilpa A, Herrera-Arellano A, Tortoriello J, Alvarez L. Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa. J Ethnopharmacol. 2010;127(1):7–10.

    Article  PubMed  CAS  Google Scholar 

  10. Ross I. Medicinal plants of the world vol. 1. 2nd ed. Totowa: Humana; 2003. p. 267–75.

    Book  Google Scholar 

  11. Adame J, Adame H. Plantas curativas del noreste Mexicano. Monterrey: Ediciones Castillo; 2000. p. 135.

    Google Scholar 

  12. Ali BH, Al Wabel N, Blunden G. Phytochemical, pharmacological and toxicological aspects of Hibiscus ­sabdariffa L.: a review. Phytother Res. 2005;19(5):369–75.

    Article  PubMed  CAS  Google Scholar 

  13. Deroles S. Anthocyanidin biosynthesis in plant cell cultures. In: Gould K, Davies K, Winefeld C, editors. Anthocyanadins: biosynthesis, functions, and applications. New York: Springer-Verlag; 2009. p. 147.

    Google Scholar 

  14. Hatier J, Gould K. Anthocyanin function in vegetative organs. In: Gould K, Davies K, Winefeld C, editors. Anthocyanadins: biosynthesis, functions, and applications. New York: Springer-Verlag; 2009. p. 1–19.

    Google Scholar 

  15. Pamplona-Roger J. Enciclopedia de los Alimentos y su Poder Curativo 3 vols. Madrid: Safeliz; 2002.

    Google Scholar 

  16. Rasdhari M, Parekh T, Dave N, Patel V, Subhash R. Evaluation of various physico-chemical properties of Hibiscus sabdariffa and L. casei incorporated probiotic yoghurt. Pak J Biol Sci. 2008;11(17):2101–8.

    Article  PubMed  CAS  Google Scholar 

  17. Adigun MO, Ogundipe OD, Anetor JI, Odetunde AO. Dose-dependent changes in some haematological ­parameters during short-term administration of Hibiscus sabdariffa Calyx aqueous extract (Zobo) in Wistar albino rats. Afr J Med Med Sci. 2006;35(1):73–7.

    PubMed  CAS  Google Scholar 

  18. Beltrán-Debón R, Alonso-Villaverde C, Aragonès G, Rodríguez-Medina I, Rull A, Micol V, et al. The aqueous extract of Hibiscus sabdariffa calices modulates the production of monocyte chemoattractant protein-1 in humans. Phytomedicine. 2009;16:186–94.

    Google Scholar 

  19. Mohamed R, Fernández J, Pineda M, Aguilar M. Roselle (Hibiscus sabdariffa) seed oil is a rich source of ­gamma-tocopherol. J Food Sci. 2007;72(3):207–11.

    Article  Google Scholar 

  20. Wang SC, Lee SF, Wang CJ, Lee CH, Lee WC, Lee HJ. Aqueous extract from Hibiscus sabdariffa Linnaeus ­ameliorate diabetic nephropathy via regulating oxidative status and Akt/Bad/14-3-3{gamma} in an experimental animal model. Evid Based Complement Alternat Med. 2009;4:1–9.

    Google Scholar 

  21. Sáyago-Ayerdi SG, Arranz S, Serrano J, Goñi I. Dietary fiber content and associated antioxidant compounds in Roselle flower (Hibiscus sabdariffa L.) beverage. J Agric Food Chem. 2007;55(19):7886–90.

    Article  PubMed  Google Scholar 

  22. Huang CN, Chan KC, Lin WT, Su SL, Wang CJ, Peng CH. Hibiscus sabdariffa inhibits vascular smooth muscle cell proliferation and migration induced by high glucose – a mechanism involves connective tissue growth factor signals. J Agric Food Chem. 2009;57(8):3073–9.

    Article  PubMed  CAS  Google Scholar 

  23. Lee WC, Wang CJ, Chen YH, Hsu JD, Cheng SY, Chen HC, et al. Polyphenol extracts from Hibiscus sabdariffa Linnaeus attenuate nephropathy in experimental type 1 diabetes. J Agric Food Chem. 2009;57(6):2206–10.

    Article  PubMed  CAS  Google Scholar 

  24. Wahabi HA, Alansary LA, Al-Sabban AH, Glasziuo P. The effectiveness of Hibiscus sabdariffa in the treatment of hypertension: A systematic review. J Ethnopharmacol. 2010;17(2):83–86.

    Article  PubMed  CAS  Google Scholar 

  25. Ojeda D, Jiménez-Ferrer E, Zamilpa A, Herrera-Arellano A, Tortoriello J, Alvarez L. Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin- and cyanidin-3-O-sambubiosides from Hibiscus sabdariffa. Phytomedicine. 2010;127(1):7–10.

    Article  PubMed  CAS  Google Scholar 

  26. Herrera-Arellano A, Miranda-Sánchez J, Avila-Castro P, Herrera-Alvarez S, Jiménez-Ferrer JE, Zamilpa A, et al. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial. Planta Med. 2007;73(1):6–12.

    Article  PubMed  CAS  Google Scholar 

  27. Lo CW, Huang HP, Lin HM, Chien CT, Wang CJ. Effect of Hibiscus anthocyanins-rich extract induces apoptosis of proliferating smooth muscle cell via activation of P38 MAPK and p53 pathway. Mol Nutr Food Res. 2007;51(12):1452–60.

    Article  PubMed  CAS  Google Scholar 

  28. Gurrola-Díaz CM, García-López PM, Sánchez-Enríquez S, Troyo-Sanromán R, Andrade-González I, Gómez-Leyva JF. Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy). Phytomedicine. 2010;17(7):500–505.

    Article  PubMed  Google Scholar 

  29. Yang MY, Peng CH, Chan KC, Yang YS, Huang CN, Wang CJ. The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance. J Agric Food Chem. 2010;58(2):850–859.

    Article  PubMed  CAS  Google Scholar 

  30. Carvajal-Zarrabal O, Hayward-Jones PM, Orta-Flores Z, Nolasco-Hipólito C, Barradas-Dermitz DM, Aguilar-Uscanga MG, et al. Effect of Hibiscus sabdariffa L. dried calyx ethanol extract on fat absorption-excretion, and body weight implication in rats. J Biomed Biotechnol. 2009;2009:5.

    Google Scholar 

  31. Ochani PC, D’Mello P. Antioxidant and antihyperlipidemic activity of Hibiscus sabdariffa Linn. leaves and ­calyces extracts in rats. Indian J Exp Biol. 2009;47(4):276–82.

    PubMed  Google Scholar 

  32. Hirunpanich V, Utaipat A, Morales NP, Bunyapraphatsara N, Sato H, Herunsalee A, et al. Antioxidant effects of aqueous extracts from dried calyx of Hibiscus sabdariffa Linn. (Roselle) in vitro using rat low-density lipoprotein (LDL). Biol Pharm Bull. 2005;28(3):481–4.

    Article  PubMed  CAS  Google Scholar 

  33. Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F. Effects of sour tea (Hibiscus ­sabdariffa) on lipid profile and lipoproteins in patients with type II diabetes. J Altern Complement Med. 2009;15(8):899–903.

    Article  PubMed  Google Scholar 

  34. McKay DL, Chen CY, Saltzman E, Blumberg JB. Hibiscus sabdariffa L. Tea (Tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J Nutr. 16 Dec 2009. doi: 10.3945 [Epub ahead of print]

    Google Scholar 

  35. Herrera-Arellano A, Flores-Romero S, Chávez-Soto MA, Tortoriello J. Effectiveness and tolerability of a ­standardized extract from Hibiscus sabdariffa in patients with mild to moderate hypertension: a controlled and randomized clinical trial. Phytomedicine. 2004;11(5):375–82.

    Article  PubMed  CAS  Google Scholar 

  36. Haji Faraji M, Haji Tarkhani A. The effect of sour tea (Hibiscus sabdariffa) on essential hypertension. Ethnopharmacology. 1999;65(3):231–6.

    Article  PubMed  CAS  Google Scholar 

  37. Mojiminiyi FB, Dikko M, Muhammad BY, Ojobor PD, et al. Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa. Fitoterapia. 2007;78(4):292–7.

    Article  PubMed  CAS  Google Scholar 

  38. Alarcon-Aguilar FJ, Zamilpa A, Perez-Garcia MD, Almanza-Perez JC, Romero-Nuñez E, Campos-Sepulveda EA, et al. Effect of Hibiscus sabdariffa on obesity in MSG mice. J Ethnopharmacol. 2007;114(1):66–71.

    Article  PubMed  CAS  Google Scholar 

  39. Lin HH, Chen JH, Kuo WH, Wang CJ. Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation. Chem Biol Interact. 2007;165(1):59–75.

    Article  PubMed  CAS  Google Scholar 

  40. Kao ES, Hsu JD, Wang CJ, Yang SH, Cheng SY, Lee HJ. Polyphenols extracted from Hibiscus sabdariffa L. inhibited lipopolysaccharide-induced inflammation by improving antioxidative conditions and regulating ­cyclooxygenase-2 expression. Biosci Biotechnol Biochem. 2009;73(2):385–90.

    Article  PubMed  CAS  Google Scholar 

  41. Chang YC, Huang HP, Hsu JD, Yang SF, Wang CJ. Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells. Toxicol Appl Pharmacol. 2005;205(3):201–12.

    Article  PubMed  CAS  Google Scholar 

  42. Tseng TH, Kao TW, Chu CY, Chou FP, Lin WL, Wang CJ. Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochem Pharmacol. 2000;60(3):307–15.

    Article  PubMed  CAS  Google Scholar 

  43. Tseng TH, Kao ES, Chu CY, Chou FP, Lin Wu HW, Wang CJ. Protective effects of dried flower extracts of Hibiscus sabdariffa L. against oxidative stress in rat primary hepatocytes. Food Chem Toxicol. 1997;35(12):1159–64.

    Article  PubMed  CAS  Google Scholar 

  44. Olvera-García V, Castaño-Tostado E, Rezendiz-Lopez RI, Reynoso-Camacho R, González de Mejía E, Elizondo G, et al. Hibiscus sabdariffa L. extracts inhibit the mutagenicity in microsuspension assay and the proliferation of HeLa cells. J Food Sci. 2008;73(5):T75–81.

    Article  PubMed  Google Scholar 

  45. Tseng TH, Kao TW, Chu CY, Chou FP, Lin WL, Wang CJ. Induction of apoptosis by hibiscus protocatechuic acid in human leukemia cells via reduction of retinoblastoma (RB) phosphorylation and Bcl-2 expression. Biochem Pharmacol. 2000;60(3):307–15.

    Article  PubMed  CAS  Google Scholar 

  46. Ali BH, Mousa HM, El-Mougy S. The effect of a water extract and anthocyanins of Hibiscus sabdariffa L. on paracetamol-induced hepatoxicity in rats. Phytother Res. 2003;17(1):56–9.

    Article  PubMed  CAS  Google Scholar 

  47. Liu JY, Chen CC, Wang WH, Hsu JD, Yang MY, Wang CJ. The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats. Food Chem Toxicol. 2006;44(3):336–43.

    Article  PubMed  CAS  Google Scholar 

  48. Adaramoye O, Ogungbenro B, Anyaegbu O, Fafunso M. Protective effects of extracts of Vernonia amygdalina, Hibiscus sabdariffa and vitamin C against radiation-induced liver damage in rats. Radiat Res (Tokyo). 2008;49(2):123–31.

    Article  CAS  Google Scholar 

  49. Prasongwatana V, Woottisin S, Sriboonlue P, Kukongviriyapan V. Uricosuric effect of Roselle (Hibiscus ­sabdariffa) in normal and renal-stone former subjects. J Ethnopharmacol. 2008;117(3):491–5.

    Article  PubMed  Google Scholar 

  50. Kirdpon S, Nakorn SN, Kirdpon W. Changes in urinary chemical composition in healthy volunteers after ­consuming roselle (Hibiscus sabdariffa Linn.) juice. Med Assoc Thai. 1994;77(6):314–21.

    CAS  Google Scholar 

  51. Ali BH, Al Wabel N, Blunden G. Phytochemical, pharmacological and toxicological aspects of Hibiscus ­sabdariffa L.: a review. Phytother Res. 2005;19(5):369–75.

    Article  PubMed  CAS  Google Scholar 

  52. Fakeye TO, Pal A, Bawankule DU, Yadav NP, Khanuja SP. Toxic effects of oral administration of extracts of dried calyx of Hibiscus sabdariffa Linn (Malvaceae). Phytother Res. 2009;23(3):412–6.

    Article  PubMed  CAS  Google Scholar 

  53. Orisakwe OE, Husaini DC, Afonne OJ. Testicular effects of sub-chronic administration of Hibiscus sabdariffa calyx aqueous extract in rats. Reprod Toxicol. 2004;18(2):295–8.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

The author would like to thank Dr. José O, Rivera, Pharm. D., director of the UTEP/UT Austin Cooperative Pharmacy Program for his constant support of this project

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González-Stuart, A. (2011). Multifaceted Therapeutic Value of Roselle (Hibiscus sabdariffa L. – Malvaceae). In: Gerald, J., Watson, R., Preedy, V. (eds) Nutrients, Dietary Supplements, and Nutriceuticals. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-60761-308-4_14

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