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Primary Care of Children with Viral Hepatitis: Diagnosis, Monitoring, and General Management

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Viral Hepatitis in Children

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References

  1. Heron M. Deaths: leading causes for 2004. Natl Vital Stat Rep 2007;56:1–95.

    PubMed  Google Scholar 

  2. Mathers CD, Bernard C, Iburg KM, Inoue M, Fate DM, Shibuya K. Global burden of disease in 2002: data sources, methods and results. World Health Organization 2003; 54.

    Google Scholar 

  3. Mast EE, Weinbaum CM, Fiore AE, et al. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) Part II: immunization of adults. MMWR Recomm Rep 2006;55:1–33; quiz CE1–4.

    PubMed  Google Scholar 

  4. Weinbaum CM, Williams I, Mast EE, et al. Recommendations for identification and public health management of persons with chronic hepatitis B virus infection. MMWR Recomm Rep 2008;57:1–20.

    PubMed  Google Scholar 

  5. McMahon BJ, Alward WL, Hall DB, et al. Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state. J Infect Dis 1985;151:599–603.

    Article  PubMed  CAS  Google Scholar 

  6. Hyams KC. Risks of chronicity following acute hepatitis B virus infection: a review. Clin Infect Dis 1995;20:992–1000.

    Article  PubMed  CAS  Google Scholar 

  7. Mast EE, Margolis HS, Fiore AE, et al. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: immunization of infants, children, and adolescents. MMWR Recomm Rep 2005;54:1–31.

    PubMed  Google Scholar 

  8. Shepard CW, Finelli L, Fiore AE, Bell BP. Epidemiology of hepatitis B and hepatitis B virus infection in United States children. Pediatr Infect Dis J 2005;24:755–60.

    Article  PubMed  Google Scholar 

  9. Zuckerman JN. Review: hepatitis B immune globulin for prevention of hepatitis B infection. J Med Virol 2007;79:919–21.

    Article  PubMed  CAS  Google Scholar 

  10. Hurie MB, Mast EE, Davis JP. Horizontal transmission of hepatitis B virus infection to United States-born children of Hmong refugees. Pediatrics 1992;89:269–73.

    PubMed  CAS  Google Scholar 

  11. Mahoney FJ, Lawrence M, Scott C, Le Q, Lambert S, Farley TA. Continuing risk for hepatitis B virus transmission among Southeast Asian infants in Louisiana. Pediatrics 1995;96:1113–6.

    PubMed  CAS  Google Scholar 

  12. Irwin GR, Allen AM, Bancroft WH, Karwacki JJ, Pinkerton RH, Russell PK. Hepatitis B antigen and antibody. Occurrence in families of asymptomatic HB AG carriers. JAMA 1974; 227:1042–3.

    Article  PubMed  CAS  Google Scholar 

  13. Chakravarty R, Chowdhury A, Chaudhuri S, et al. Hepatitis B infection in Eastern Indian families: need for screening of adult siblings and mothers of adult index cases. Public Health 2005;119:647–54.

    Article  PubMed  CAS  Google Scholar 

  14. Haber BA, Block JM, Jonas MM, et al. Recommendations for screening, monitoring, and referral of pediatric chronic hepatitis B. Pediatrics 2009;124:e1007–13.

    Article  PubMed  Google Scholar 

  15. Hoofnagle JH, Doo E, Liang TJ, Fleischer R, Lok AS. Management of hepatitis B: summary of a clinical research workshop. Hepatology 2007;45:1056–75.

    Article  PubMed  CAS  Google Scholar 

  16. Jonas MM. Children with hepatitis C. Hepatology 2002;36:S173–8.

    Article  PubMed  Google Scholar 

  17. Mast EE, Alter MJ, Margolis HS. Strategies to prevent and control hepatitis B and C virus infections: a global perspective. Vaccine 1999;17:1730–3.

    Article  PubMed  CAS  Google Scholar 

  18. Hepatitis C. In: Red Book; 2009. p. 357–60.

    Google Scholar 

  19. Alter MJ. Prevention of spread of hepatitis C. Hepatology 2002;36:S93–8.

    Article  PubMed  Google Scholar 

  20. American Academy of Pediatrics. Hepatitis C virus infection. Committee on infectious ­diseases. In: Pediatrics; 1998. p. 481–5.

    Google Scholar 

  21. Hillyer CD, Josephson CD, Blajchman MA, Vostal JG, Epstein JS, Goodman JL. Bacterial contamination of blood components: risks, strategies, and regulation: joint ASH and AABB educational session in transfusion medicine. Hematology Am Soc Hematol Educ Program 2003:575–89.

    Google Scholar 

  22. Wasley A, Alter MJ. Epidemiology of hepatitis C: geographic differences and temporal trends. Semin Liver Dis 2000;20:1–16.

    Article  PubMed  CAS  Google Scholar 

  23. Hnatyszyn HJ. Chronic hepatitis C and genotyping: the clinical significance of determining HCV genotypes. Antivir Ther 2005;10:1–11.

    PubMed  CAS  Google Scholar 

  24. Pawlotsky JM. Use and interpretation of virological tests for hepatitis C. Hepatology 2002;36:S65–73.

    Article  PubMed  Google Scholar 

  25. Roberts EA, Yeung L. Maternal-infant transmission of hepatitis C virus infection. Hepatology 2002;36:S106–13.

    Article  PubMed  Google Scholar 

  26. Yeung LT, King SM, Roberts EA. Mother-to-infant transmission of hepatitis C virus. Hepatology 2001;34:223–9.

    Article  PubMed  CAS  Google Scholar 

  27. Zanetti AR, Tanzi E, Newell ML. Mother-to-infant transmission of hepatitis C virus. J Hepatol 1999;31 (Suppl 1):96–100.

    Article  PubMed  Google Scholar 

  28. Krawczynski K, Alter MJ, Tankersley DL, et al. Effect of immune globulin on the prevention of experimental hepatitis C virus infection. J Infect Dis 1996;173:822–8.

    Article  PubMed  CAS  Google Scholar 

  29. Strader DB, Wright T, Thomas DL, Seeff LB. Diagnosis, management, and treatment of hepatitis C. Hepatology 2004;39:1147–71.

    Article  PubMed  Google Scholar 

  30. Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med 2001;345:41–52.

    Article  PubMed  CAS  Google Scholar 

  31. Fried MW. Diagnostic testing for hepatitis C: practical considerations. Am J Med 1999;107: 31S–5S.

    Article  PubMed  CAS  Google Scholar 

  32. National Institutes of Health Consensus Development Conference Statement: Management of hepatitis C 2002 (June 10–12, 2002). Gastroenterology 2002;123(6):2082–99.

    Google Scholar 

  33. Poynard T, Marcellin P, Lee SS, et al. Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (IHIT). Lancet 1998;352:1426–32.

    Article  PubMed  CAS  Google Scholar 

  34. McHutchison JG, Gordon SC, Schiff ER, et al. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N Engl J Med 1998;339:1485–92.

    Article  PubMed  CAS  Google Scholar 

  35. Ceci O, Margiotta M, Marello F, et al. High rate of spontaneous viral clearance in a cohort of vertically infected hepatitis C virus infants: what lies behind? J Hepatol 2001;35:687–8.

    Article  PubMed  CAS  Google Scholar 

  36. National Institutes of Health Consensus Development Conference Panel statement: management of hepatitis C. Hepatology 1997;26:2S–10S.

    Google Scholar 

  37. Jara P, Hierro L, de la Vega A, et al. Efficacy and safety of peginterferon-alpha2b and ribavirin combination therapy in children with chronic hepatitis C infection. Pediatr Infect Dis J 2008;27:142–8.

    PubMed  Google Scholar 

  38. Schwarz KB, Gonzalez-Peralta RP, Murray KF, et al. Peginterferon with or without ribavirin for chronic Hepatitis C in children and adolescents: final results of the PEDS-C trial. Hepatology 2008;48:418A.

    Article  Google Scholar 

  39. Fontana RJ, Lok AS. Noninvasive monitoring of patients with chronic hepatitis C. Hepatology 2002;36:S57–64.

    Article  PubMed  Google Scholar 

  40. Roache K, Haber B. Hepatitis C Virus infection. Pediatric Eastroenterology Board Review Manual 2007; Volume 1, Part 3:2–9.

    Google Scholar 

  41. CDC. Recommendations for prevention and control of Hepatitis C Virus (HCV) infection and HCV-related chronic disease. MMWR Recomm Rep. 1998;47:1–39.

    Google Scholar 

  42. Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet 1997;349:825–32.

    Article  PubMed  CAS  Google Scholar 

  43. Harris DR, Gonin R, Alter HJ, et al. The relationship of acute transfusion-associated hepatitis to the development of cirrhosis in the presence of alcohol abuse. Ann Intern Med 2001;134:120–4.

    PubMed  CAS  Google Scholar 

  44. Wiley TE, McCarthy M, Breidi L, Layden TJ. Impact of alcohol on the histological and clinical progression of hepatitis C infection. Hepatology 1998;28:805–9.

    Article  PubMed  CAS  Google Scholar 

  45. Kelly D, Haber B, Gonzalez-Peralta RP, et al. Sustained virologic response to interferon alfa-2b plus ribavirin predicts long-term clearance of HCV in pediatric patients at 5 year ­follow-up. J Hepatol 2008;48:S298–9.

    Article  Google Scholar 

  46. Lindsay K, Manns MP, Gordon SC, et al. S1001 Clearance of HCV at 5 year follow-up for peginterferon alfa-2b ± ribavirin is predicted by sustained virologic response at 24 weeks post treatment. Gastroenterology 2008;134:A-772.

    Article  Google Scholar 

  47. Maylin S, Martinot-Peignoux M, Moucari R, et al. Eradication of hepatitis C virus in patients successfully treate for chronic hepatitis C. Gastroenterology 2008;135:821–9.

    Article  PubMed  Google Scholar 

  48. Ghany MG, Strader DB, Thomas DL, Seeff LB. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009;49:1335–74.

    Article  PubMed  CAS  Google Scholar 

  49. Hourigan LF, Macdonald GA, Purdie D, et al. Fibrosis in chronic hepatitis C correlates ­significantly with body mass index and steatosis. Hepatology 1999;29:1215–9.

    Article  PubMed  CAS  Google Scholar 

  50. Ortiz V, Berenguer M, Rayon JM, Carrasco D, Berenguer J. Contribution of obesity to hepatitis C-related fibrosis progression. Am J Gastroenterol 2002;97:2408–14.

    Article  PubMed  Google Scholar 

  51. Chen CL, Yang HI, Yang WS, et al. Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan. Gastroenterology 2008; 135:111–21.

    Article  PubMed  CAS  Google Scholar 

  52. Seeff LB, Lindsay KL, Bacon BR, Kresina TF, Hoofnagle JH. Complementary and alternative medicine in chronic liver disease. Hepatology 2001;34:595–603.

    Article  PubMed  CAS  Google Scholar 

  53. Kukka C. Bloodborne infections: should they be disclosed? Is differential treatment necessary? J Sch Nurs 2004;20:324–30.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of GI and Nutrition, Children’s Hospital of Philadelphia, 34th St & Civic Ctr Blvd, Philadelphia, PA, 19104, USA

    Jessi Erlichman

Authors
  1. Jessi Erlichman
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  2. Will Mellman
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  3. Barbara A. Haber
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Corresponding author

Correspondence to Jessi Erlichman .

Editor information

Editors and Affiliations

  1. Division of Gastroenterology, Children's Hospital Boston, 300 Longwood Ave., Boston, 02115, USA

    Maureen M. Jonas

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Erlichman, J., Mellman, W., Haber, B.A. (2010). Primary Care of Children with Viral Hepatitis: Diagnosis, Monitoring, and General Management. In: Jonas, M. (eds) Viral Hepatitis in Children. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-373-2_9

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  • DOI: https://doi.org/10.1007/978-1-60761-373-2_9

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  • Publisher Name: Humana Press, Totowa, NJ

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