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Modulation of Human Dendritic Cells by Highly Virulent Pathogens

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National Institute of Allergy and Infectious Diseases, NIH

Part of the book series: Infectious Disease ((ID))

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Abstract

Since the recognition of microorganisms as the etiological cause of disease, scientists have studied the intimate interaction between pathogen and host in hopes of developing effective vaccines, diagnostics, and therapeutics. In turn, these studies have greatly enriched our understanding of both the microbial world and our own immune system. Early on, it became apparent that successful infection, replication and dissemination of many of the most virulent pathogens was directly tied to usurpation of host pathways that regulate and temper the immune response or that directly suppress inflammation and antigen presentation in total. Here we will discuss the modulation of host immune responses, with a special emphasis on dendritic cells and in vivo models by the highly virulent pathogens, Ebola and Marburg viruses (EBOV and MARV, respectively) and the Gram negative bacterium, Francisella tularensis.

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Author information

Authors and Affiliations

  1. Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, USA

    Catharine M. Bosio

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  1. Catharine M. Bosio
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Editors and Affiliations

  1. Dept. Health & Human Services, National Institute of Health, Rockledge Drive 6610, Bethesda, 20892, Maryland, USA

    Vassil St. Georgiev

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Bosio, C.M. (2010). Modulation of Human Dendritic Cells by Highly Virulent Pathogens. In: Georgiev, V. (eds) National Institute of Allergy and Infectious Diseases, NIH. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-512-5_20

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  • DOI: https://doi.org/10.1007/978-1-60761-512-5_20

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-511-8

  • Online ISBN: 978-1-60761-512-5

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