Abstract
A significant proportion of patients with gastroparesis do not respond adequately to standard medical treatment and gastric electric stimulation (GES). Loss of interstitial cells of Cajal (ICCs) on full-thickness gastric biopsies has been shown to be a predictor of poor response to GES. Full-thickness gastric biopsies may help diagnose severe depletion of ICCs and/or other specific gastric abnormalities, which hopefully will guide diagnosis and specific individualized and targeted therapies. Recent advances in endoscopic techniques have allowed the development of novel methods to obtain full-thickness gastric biopsies. Further refinement of these techniques is needed to improve their safety and applicability.
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Rukshana Cader has no conflicts of interest to disclose. Mouen Khashab has no conflicts of interest to disclose. Anthony Kalloo is a founding Member, equity Holder and consultant for Apollo Endosurgery.
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Cader, R.N., Khashab, M.A., Kalloo, A.N. (2012). Endoscopic Full-Thickness Gastric Biopsy for Evaluation of Patients. In: Parkman, H., McCallum, R. (eds) Gastroparesis. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-60761-552-1_31
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