Abstract
High-dose-rate endorectal brachytherapy (HDREBT) is a novel treatment modality for patients with rectal cancer. It is based on modern tumor imaging, in particular magnetic resonance imaging (MRI), which is used to choose eligible patients and improve tumor visualization. Treatment planning is performed using 3D CT simulation and 3D treatment planning. Treatments are delivered on an outpatient basis and require minimal local anesthesia. Validation of this technique was carried out through a preoperative study. In this chapter, we describe the technical aspects of HDREBT and the ongoing studies exploring the clinical applications of this treatment modality for patients with rectal cancer: As neoadjuvant treatment for patients with operable rectal tumor As a dose escalation modality following external beam radiation for elderly and medically inoperable patients As a modality to promote to sphincter preservation surgery (SPS) for patients with low-lying rectal cancer As an option to improve local control in patients with newly diagnosed rectal cancer in the setting of previous pelvic radiation therapy
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Vuong, T., Devic, S., Podgorsak, E. (2010). High-Dose-Rate Preoperative Endorectal Brachytherapy for Patients with Rectal Cancer. In: Czito, B., Willett, C. (eds) Rectal Cancer. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-567-5_17
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DOI: https://doi.org/10.1007/978-1-60761-567-5_17
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