Abstract
Stem cell research is advancing at an incredible pace, with new discoveries and clinical applications being reported from all over the world. Stem cells are functionally defined by their ability to self-renew and to differentiate into the cell lineages of their tissue of origin. Stem cells are self-sustaining and can replicate themselves for long periods of time. These characteristics make them very promising for treating debilitating disorders such as heart diseases, liver diseases, stroke, spinal injuries, Parkinson disease, Alzheimer disease, retinal degeneration, muscular dystrophy, diabetes mellitus, and so on. Stem cell therapy has generated interest in clinicians and the public. Clinical applications have been reported in heart diseases, spinal cord injury, ischemic limbs, retinal degeneration, and liver diseases. This chapter summarizes recent developments concerning gastrointestinal stem cells.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Moore, K. A. and Lemischka, I.R. (2006) Stem cells and their niches. Science 311, 1880–1885.
Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S, et al. (1998) Embryonic stem cell lines derived from human blastocysts. Science. 282, 1145–1147.
Barrilleaux, B., Phinney, D.G., Prockop, D.J., et al. (2006) Review: ex vivo engineering of living tissues with adult stem cells. Tissue Eng. 12, 3007–3019.
Leblond, C. P., (1959) Am. J. Anatomy. 104, 237–271.
Burns, A.J., Pasricha, P.J., Young, H.M., (2004) Enteric neural crest derived cells: biology and therapeutic potential. Neuro gastroenterology and Motility, 16 Supplement, 3–7.
Serry, J.P. and Watt, F.M., (2000) Asymmetric stem cells divisions define the architecture of the human oesophageal epithelium. Curr. Boil. 10, 1447–1450.
Serry, J. P. (2002). J. Cell Sci. 115 (9), 1783–1789.
Radtke, F. and Clevers, H., 2005, Self renewal and cancer of the gut: two sides of a coin. Science 307, 1904–1909.
Ponder, B.A., Schmidt, G.H., Wilkinson, M.M., et al. (1985) Derivation of mouse intestinal crypts from single progenitor cells. Nature. 313, 689–691.
Bjerknes, M.H. and Cheng, M. (1999) Clonal analysis of mouse intestinal epithelial progenitors, Gastroenterology. 116 (1):208–210.
Whitehead, R.H., Demmler, K., Rockman, S. P., (1999) Clonogenic growth of epithelial cells from normal colonic mucosa from both mice and humans. Gastroenterology 117, 858–865.
Bjerknes, M. and Cheng. H. (2005) Gastrointestinal Stem Cells. II. Intestinal stem cells. Am J Physiol. (Gastrointest LiverPhysiol). 289; G 381–G 387.
Krause, D.S., Theise, N.D., collector, M.I., et al. (2001) Multiorgan, multilineage engraftment by a single bone marrow derived stem cells. Cell. 105, 369–377.
Cedric, B., Horsley, V and Fuchs, E. (2007). Epithelial stem cells: Turning over new leaves; Cell 128. 445–457.
Alison, M.R., Golding, M.H., Sarraf, C.E., (1996) Pluripotential liver stem cells: facultative stem cells located in the biliary tree. Cell Proli. 2, 373–402.
Theise, N.D., Saxena, R.,, Portmann, B.C., et al. (1999) The canals of Hering and hepatic stem cells in humans. Hepatology. 30, 1425–1433.
Petersen, B.E., Bowen, W.C., Patrene, K.D. et al. (1999) Bone marrow as a potential source of hepatic oval cells. Science. 284 (5417), 1168–1170.
Habibullah, C.M., Syed, I.H., Qamar, A., et al. (1994) Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation. 58:951–952.
Lijun, Y., Li, S., Hatch. H., et al. (2002) In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Procd. Natl. Acad. Sci. USA, 99, 8078–8083.
Stadtfeld,, M., Brennand, K. and Hochedlinger, K., (2008) Reprogramming of pancreatic β cells into induced pluripotent stem cells. Curr. Biol. 18, 890–894.
Hanna, J., Markoulaki, S., Schorderet, P., et al. (2008) Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell 133, 250–264.
Takashi, A., Kojiro, Y., Nakagawa, M., et al (2008) Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells. Science. 321, 699–702.
Campagnoli C., Fisk N., Overton T., et al. (2000) Circulating hematopoietic progenitor cells in first trimester fetal blood. Blood. 95, 1967–1972.
Gallacher L., Murdoch B., Wu D., et al. (2000). Identification of novel circulating human embryonic blood stem cells. Blood. 96, 1740–1747.
Cherry, Yasumizu R., Toki J., et al. (1994) Production of hematopoietic stem cell-chemotactic factor by bone marrow stromal cells. Blood. 83, 964–971.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Parveen, N., Khan, A.A., Habeeb, M.A., Habibullah, C.M. (2011). Gastrointestinal Stem Cells. In: Appasani, K., Appasani, R. (eds) Stem Cells & Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-860-7_13
Download citation
DOI: https://doi.org/10.1007/978-1-60761-860-7_13
Published:
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-60761-859-1
Online ISBN: 978-1-60761-860-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)