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The Role of 5-HT2C Receptors in the Pathophysiology and Treatment of Depression

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5-HT2C Receptors in the Pathophysiology of CNS Disease

Part of the book series: The Receptors ((REC,volume 22))

Abstract

There is considerable evidence supporting the involvement of serotonin-2C (5-HT2C) receptors in the pathophysiology of depression. First, 5-HT2C receptors play an important role in the regulation of monoamine transmission. Second, abnormalities in expression and functioning of 5-HT2C receptors have been observed in depressed patients and in animal models of depression. Third, a large body of evidence indicates that 5-HT2C receptors mediate certain behavioral functions that are disturbed in depression. Finally, some compounds acting on 5-HT2C receptors are effective in the treatment of depression. This chapter aims to summarize these four lines of evidence for the involvement of 5-HT2C receptors in pathophysiology and treatment of depression.

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Author information

Authors and Affiliations

  1. Brains On-Line BV, Groningen, The Netherlands

    Eliyahu Dremencov

  2. Brains On-Line US LLC, San-Francisco, CA, USA

    Thomas I. F. H. Cremers

Authors
  1. Eliyahu Dremencov
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  2. Joost H. A. Folgering
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  3. Sandra Hogg
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  4. Laurence Tecott
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  5. Thomas I. F. H. Cremers
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Corresponding authors

Correspondence to Eliyahu Dremencov or Thomas I. F. H. Cremers .

Editor information

Editors and Affiliations

  1. , Department of Physiology and Biochemistr, University of Malta, Msida, Malta, MSD 2080, Italy

    Giuseppe Di Giovanni

  2. Centro di Ricerche Farmacologiche e, Biomediche, Consorzio Mario Negri Sud, Via Nazionale 8, Santa Maria Imbaro, 66030, Chieti, Italy

    Ennio Esposito

  3. Centro di Ricerche Farmacologiche e, Biomediche, Consorzio Mario Negri Sud, Via Nazionale 8, Santa Maria Imbaro, 66030, Chieti, Italy

    Vincenzo Di Matteo

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Dremencov, E., Folgering, J.H.A., Hogg, S., Tecott, L., Cremers, T.I.F.H. (2011). The Role of 5-HT2C Receptors in the Pathophysiology and Treatment of Depression. In: Di Giovanni, G., Esposito, E., Di Matteo, V. (eds) 5-HT2C Receptors in the Pathophysiology of CNS Disease. The Receptors, vol 22. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-941-3_12

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