Abstract
In this chapter we address two aspects – the static physical interactions which allow the information transfer for the function to be performed; and the dynamic, i.e. how the information is transmitted between the binding sites in the single protein molecule and in the network. We describe the single protein molecules and their complexes; and the analogy between protein folding and protein binding. Eventually, to fully understand the interactome and how it performs the essential cellular functions, we have to put all together - and hierarchically progress through the system.
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Keskin, O., Gursoy, A., Nussinov, R. (2008). Principles of Protein Recognition and Properties of Protein-protein Interfaces. In: Panchenko, A., Przytycka, T. (eds) Protein-protein Interactions and Networks. Computational Biology, vol 9. Springer, London. https://doi.org/10.1007/978-1-84800-125-1_3
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DOI: https://doi.org/10.1007/978-1-84800-125-1_3
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