Abstract
This edition, the fourth in a series spanning some 25 years since the publication of the first edition in 1983, is likely to be the last prepared under the current authorship. In addition to chronicling further progress in the field, it seems appropriate to add a final chapter concerning areas that might be suitable, even ripe, for translational research in the future. This chapter, at times unashamedly speculative, synthesises the ideas of all three authors, each approaching the field from their slightly different perspectives. We apologise to readers if some of our suggestions prove impractical or if we have failed to consider their own areas of particular interest in this wide field.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Wood PH. Is hypermobility a discrete entity? Proc R Soc Med. 1971;64:690-692.
Heiss G, Sharrett AR, Barnes R, et al. Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol. 1991;134:250-256.
O’Leary DH, Polak JF, Kronmal RA, et al. Thickening of the carotid wall. A marker of atherosclerosis in the elderly? Stroke. 1996;27:224-231.
Roman MJ, Devereux RB, Schwartz JE, et al. Arterial stiffness in chronic inflammatory diseases. Hypertension. 2005;46:194.
Inaba M, Tanaka K, Goto H, et al. Independent association of increased trunk fat with increased arterial stiffening in postmenopausal patients with rheumatoid arthritis. J Rheumatol. 2007;34:290-295.
Chow P-C, Ho MH-K, Lee T-L, Lau Y-L, Cheung Y-F. Relation of arterial stiffness to left ventricular structure and function in adolescents and young adults with paediatric-onset systemic lupus erythematosus. J Rheumatol. 2007;34:1345-1352.
Ng WF, Fantin F, Ng C, et al. Takayasu’s arteritis: a cause of prolonged arterial stiffness. Rheumatology (Oxford). 2006;45:741-745.
Pope FM, Narcisi P, Nicholls AC, Germaine D, Pals G, Richards AJ. COL3A1 mutations cause variable clinical phenotypes including acrogeria and vascular rupture. Br J Dermatol. 1996;135:163-181.
Sakai LY, Keene DR, Engvall E. Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils. J Cell Biol. 1986;103:2499-2509.
Bird HA. Heritable collagen disorder. In: Reports on the Rheumatic Diseases (Series 5): Topical Reviews. Chesterfield: Arthritis Research Campaign; 2005.
Pereira L, D’Alessio M, Ramirez F, et al. Genomic organization of the sequence coding for fibrillin, the defective gene product in Marfan syndrome. Hum Mol Genet. 1993;2:961-968.
Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J. Latent transforming growth factor-β binding proteins (LTBPs) – structural extracellular matrix proteins for targeting TGF-β action. Cytokine Growth Factor Rev. 1999;10:99-117.
Ng CM, Cheng A, Myers LA, et al. TGF-β-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome. J Clin Invest. 2004;114:1586-1592.
Mizuguchi T, Collod-Beroud G, Akiyama T, et al. Heterozygous TGFBR 2 mutations in Marfan syndrome. Nat Genet. 2004;36:855-860.
Loeys BL, Chen J, Neptune ER, et al. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR 1 or TGFBR 2 . Nat Genet. 2005;37:275-281.
Farmer AD, Zarate-Lopez N, Mohammed S, Scott SM, Knowles CH, Grahame R, Aziz Q. Joint hypermobility and functional gastrointestinal disorders: is connective tissue the missing link? Rheumatology (Oxford). 2009;48(suppl 1):Abstract 217, 95.
Morgan AW, Pearson SB, Davies S, Gooi HC, Bird HA. Asthma and airways collapse in two heritable disorders of connective tissue. Ann Rheum Dis. 2007;66:1369-1373.
Aktas I, Ofluoglu D, Albay T. The relationship between benign joint hypermobility syndrome and carpal tunnel syndrome. Clin Rheumatol. 2008;27:1283-1297.
Ofluoglu D, Gunduz OH, Kul-Panza E, Guven Z. Hypermobility in women with fibromyalgia syndrome. Clin Rheumatol. 2006;25:291-293.
Sendur OF, Gurer G, Bozbas GT. The frequency of hypermobility and its relationship with clinical findings of fibromyalgia patients. Clin Rheumatol. 2007;26:485-487.
Ferrell WR, Tennant N, Sturrock RD, et al. Amelioration of symptoms by enhancement of proprioception in patients with joint hypermobility syndrome. Arthritis Rheum. 2004;50:3323-3328.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag London Limited
About this chapter
Cite this chapter
Beighton, P., Grahame, R., Bird, H. (2012). Future Avenues for Research. In: Hypermobility of Joints. Springer, London. https://doi.org/10.1007/978-1-84882-085-2_10
Download citation
DOI: https://doi.org/10.1007/978-1-84882-085-2_10
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-84882-084-5
Online ISBN: 978-1-84882-085-2
eBook Packages: MedicineMedicine (R0)