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Immunology of Tissue Transplantation

  • Chapter
Plastic and Reconstructive Surgery

Part of the book series: Springer Specialist Surgery Series ((SPECIALIST))

Summary

Composite tissue allograft (CTA) is one of the tissue reconstruction options in plastic and reconstructive surgery. Surgical techniques in CTA are well established; however, the immunologic characters of the components of CTA still require extensive research to protect allografts from rejection. CTA are histologically heterogeneous and composed of tissues such as skin, muscle, bone with bone marrow, lymph nodes, nerves, and vessels, which represent variable levels of immunogenicity and may generate different types of immunologic responses.

This chapter introduces the immunological status of CTA components, the role of immu-nomodulatory and inflammatory mediators for allograft acceptance, immune response to foreign antigens, and the hierarchy of anti-genicity of individual components of CTA compared with the whole CTA transplant.

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Abbreviations

APC:

Antigen-presenting cells

CGRP:

Calcitonin gene-related peptide

CLA:

Cutaneous lymphocyte-associated antigen

CTA:

Composite tissue allografts

DDC:

Dermal dendritic cells

FDC:

Follicular dendritic cells

ICAM-1:

Intercellular adhesion molecule-1

LC:

Langerhans cells

MAd-CAM-1:

Mucosal addressin cellular adhesion molecule-1

MHC:

Major histocompatibility complex

OPN:

Osteopontin

SALT:

Skin-associated lymphoid tissues

SIS:

Skin immune system

Tc:

T cytotoxic

Th:

T-helper

VCAM-1:

Vascular cell adhesion molecule-1

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Authors and Affiliations

  1. Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA

    Aleksandra Klimczak & Maria Siemionow

Authors
  1. Aleksandra Klimczak
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  2. Maria Siemionow
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Editor information

Editors and Affiliations

  1. Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA

    Maria Z. Siemionow (Professor of Surgery, Director of Plastic Surgery Research, Head of Microsurgery Training) (Professor of Surgery, Director of Plastic Surgery Research, Head of Microsurgery Training)

  2. Department of Plastic and Aesthetic, Hand, and Reconstructive Surgery, Caritas-Krankenhaus St. Josef, affiliated with Regensburg University, Regensburg, Germany

    Marita Eisenmann-Klein (Director) (Director)

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Klimczak, A., Siemionow, M. (2010). Immunology of Tissue Transplantation. In: Siemionow, M.Z., Eisenmann-Klein, M. (eds) Plastic and Reconstructive Surgery. Springer Specialist Surgery Series. Springer, London. https://doi.org/10.1007/978-1-84882-513-0_2

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  • DOI: https://doi.org/10.1007/978-1-84882-513-0_2

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-512-3

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