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Heat Shock Protein 60: A Mediator of Atherosclerosis and Its Potential Therapeutic Role

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Chaperokine Activity of Heat Shock Proteins

Part of the book series: Heat Shock Proteins ((HESP,volume 16))

Abstract

Heat shock proteins (HSP) are highly conserved families of proteins expressed by a number of cell types following exposure to stressful environmental conditions in order to protect the cells from injury. The ability of a cell to withstand these environmental stresses is critical to its capacity to adapt and remain viable. Loss of this ability may lead to a pathological state. Abnormal localization, structure or function of HSP has been associated with different pathologies, including atherosclerosis. HSP60 has in particular been identified as playing important roles in inflammatory pathways and immune reactions in atherosclerosis. This chapter will highlight the role of HSP60 in atherosclerosis and the potential to target HSP60 or peptides thereof to alter the progression or even treat atherosclerosis.

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Abbreviations

ACE:

Acute coronary syndrome

AGE:

Advanced glycation end product

APC:

Antigen-presenting cell

ApoE−/− :

Apolipoprotein E deficient

cHSP60:

Chlamydia pneumonia heat shock protein 60

CVD:

Cardiovascular disease

DC:

Dendritic cell

GARP:

Glycoprotein A representations predominant

GroEL:

Human heat shock protein 60 produced in Escherichia coli

HCD:

High cholesterol diet

hHSP60:

Human heat shock protein 60

HSP:

Heat shock protein

ICAM-1:

Intracellular adhesion molecule-1

IFN:

Interferon

IL:

Interleukin

IMT:

Inter media thickness

LAP:

Latency associated peptide

LDL:

Low-density lipoprotein

LDLr−/− :

Low lipoprotein receptor deficient

LPS:

Lipopolysaccharides

mbHSP65:

Mycobacterial tuberculosis heat shock protein 65

MHC:

Major histocompatibility complex

NO:

Nitric oxid

oLDL:

Oxidized low-density lipoprotein

PBMC:

Peripheral blood mononuclear cells

RA:

Rheumatoid arthritis

RAG1−/− :

V(D)J recombination activation gene 1 deficient

rCTD:

Rat C-terminal determinants

rHSP65:

Rat heat shock protein 65

SCID:

Severe combined immunodeficiency

sHSP60:

Soluble heat shock protein 60

SLE:

Systemic lupus erythematous

SMC:

Smooth muscle cell

TGF:

Transforming growth factor

TLR:

Toll-like receptor

TNF:

Tumor necrosis factor

Treg:

Regulatory T cell

VCAM-1:

Vascular cell adhesion molecule-1

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Acknowledgements

I grateful to Professor em. Georg Wick, Laboratory of Autoimmunity, Section of Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria, for his kind help and valuable comments.

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  1. Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Karolinska University Hospital Solna, Center for Molecular Medicine (CMM), Stockholm, Sweden

    Cecilia Wick

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  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Wick, C. (2019). Heat Shock Protein 60: A Mediator of Atherosclerosis and Its Potential Therapeutic Role. In: Asea, A., Kaur, P. (eds) Chaperokine Activity of Heat Shock Proteins . Heat Shock Proteins, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-030-02254-9_4

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