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Protons and Heavy Ions

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Salivary Gland Cancer

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Abstract

Particle therapy as proton or heavy ion therapy has several dosimetric and biological advantages over photon radiotherapy. To date, access to this treatment modality is limited, and treatment costs are still considerably higher than for standard photon radiotherapy.

However, particle therapy has shown promising results especially in locally advanced salivary gland cancers.

The chapter will provide an overview of physical and biological basics of particle radiotherapy in general and for malignant salivary gland tumours in particular. It will examine and discuss rationale and available clinical evidence for carbon ion and proton therapy in this challenging disease.

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Abbreviations

ACC:

Adenoid cystic carcinoma

ART:

Adaptive radiotherapy

BED:

Biological effective dose

C12:

Carbon ions

CTCAE:

Common Terminology Criteria for Adverse Events

EORTC:

European Organisation for Research and Treatment of Cancer

ICRU:

International Commission on Radiation Units and Measurements

IGRT:

Image-guided radiotherapy

IMRT:

Intensity-modulated radiotherapy

LEM:

Local effects model

LET:

Linear energy transfer

MKM:

Microdosimetric kinetic model

MRC:

Medical Research Council

MSGT:

Malignant salivary gland tumour

NTCP:

Normal tissue complication probability

OAR:

Organ at risk

RBE:

Relative biological effectiveness

RTOG:

Radiation Therapy Oncology Group

SOBP:

Spread-out Bragg peak

VMAT:

Volumetric arc therapy

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Authors and Affiliations

  1. Department of Radiation Oncology Gießen, University Hospital Gießen and Marburg (UKGM), Marburg, Germany

    A. D. Jensen

  2. Fondazione CNAO, Pavia, Italy

    P. Fossati

  3. EBG MedAustron GmbH, Wiener Neustadt, Austria

    P. Fossati

Authors
  1. A. D. Jensen
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  2. P. Fossati
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Correspondence to A. D. Jensen .

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Editors and Affiliations

  1. Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Milan, Italy

    Lisa Licitra

  2. Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Milan, Italy

    Laura D. Locati

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Jensen, A.D., Fossati, P. (2019). Protons and Heavy Ions. In: Licitra, L., Locati, L. (eds) Salivary Gland Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-02958-6_12

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