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In vivo, In vitro, and In silico Studies of the GI Tract

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Interdisciplinary Approaches to Food Digestion

Abstract

This chapter is divided into three sections, each presenting a different type of methodologies that are commonly used to study the link between food digestion and health. The first section focuses on in vivo methods, which are those that involve a living organism. The main types of epidemiological study design are presented, including observational and intervention studies. The relatively new field of nutritional epidemiology is further introduced, while animal studies are also briefly considered. The second section concerns in vitro experiments, which simulate digestive processes outside the body. The principles and practicalities of different static and dynamic in vitro models encountered in the literature are presented. Further, in silico approaches to digestion studies are discussed in the third section, with emphasis on developing understanding of digestive processes using numerical and computer techniques, with the aim to produce predictive models.

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Authors and Affiliations

  1. School of Chemical Engineering, University of Birmingham, Birmingham, UK

    Syahrizal Muttakin & Thomas E. Moxon

  2. Indonesian Agency for Agricultural Research and Development, Yogyakarta, Indonesia

    Syahrizal Muttakin

  3. Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham, UK

    Ourania Gouseti

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  1. Syahrizal Muttakin
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  2. Thomas E. Moxon
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  3. Ourania Gouseti
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Correspondence to Ourania Gouseti .

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Editors and Affiliations

  1. Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham, UK

    Ourania Gouseti

  2. Biological and Agricultural Engineering, University of California, Davis, CA, USA

    Gail M. Bornhorst

  3. Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham, UK

    Serafim Bakalis

  4. School of Food Science and Nutrition, University of Leeds, Leeds, UK

    Alan Mackie

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Muttakin, S., Moxon, T.E., Gouseti, O. (2019). In vivo, In vitro, and In silico Studies of the GI Tract. In: Gouseti, O., Bornhorst, G., Bakalis, S., Mackie, A. (eds) Interdisciplinary Approaches to Food Digestion. Springer, Cham. https://doi.org/10.1007/978-3-030-03901-1_3

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