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Viruses and Glioblastoma: Affliction or Opportunity?

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Microbiome and Cancer

Part of the book series: Current Cancer Research ((CUCR))

Abstract

Herpesviruses, polyomaviruses, and papillomaviruses have all been detected in glioblastoma cells and/or cell lines. Our group first published evidence of human cytomegalovirus (CMV), a herpesvirus, in glioblastoma specimens from immunocompetent patients in 2002. However, the discovery of CMV and other viruses in glioblastoma has met with controversy following several studies that failed to detect viral particles in GBM. Here we summarize the known relationships between viruses and malignant gliomas, including viral detection in GBM, the oncomodulatory effects of GBM-associated viruses, and the novel ways by which investigators are targeting viruses for the treatment of glioblastoma.

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Abbreviations

BKV:

B.K. virus

CNS:

Central nervous system

CMV:

Cytomegalovirus

DC:

Dendritic cell

EBV:

Epstein-Barr virus

GBM:

Glioblastoma

HHV:

Human herpesvirus

HPV:

Human papillomavirus

IE:

Immediate-early

JCV:

John Cunningham virus

Tag:

Large tumor antigen

MGMT:

O6-Methylguanine-DNA-methyltransferase

pp:

Phosphoprotein

PDGFRα:

Platelet-derived growth factor receptor alpha

rGBM:

Recurrent GBM

SV40:

Simian virus 40

tag:

Small tumor antigen

TMZ:

Temozolomide

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Authors and Affiliations

  1. Swedish Neuroscience Institute, Center for Advanced Brain Tumor Treatment, Seattle, WA, USA

    Haidn Foster & Charles S. Cobbs

  2. University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Haidn Foster

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  1. Department of Otorhinolaryngology – Head and Neck Surgery Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Erle S. Robertson

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Foster, H., Cobbs, C.S. (2019). Viruses and Glioblastoma: Affliction or Opportunity?. In: Robertson, E. (eds) Microbiome and Cancer. Current Cancer Research. Humana Press, Cham. https://doi.org/10.1007/978-3-030-04155-7_4

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