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Eye Disease Prediction from Optical Coherence Tomography Images with Transfer Learning

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Engineering Applications of Neural Networks (EANN 2019)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 1000))

Abstract

Optical Coherence Tomography (OCT) of the human eye are used by optometrists to analyze and detect various age-related eye abnormalities like Choroidal Neovascularization, Drusen (CNV), Diabetic Macular Odeama (DME), Drusen. Detecting these diseases are quite challenging and requires hours of analysis by experts, as their symptoms are somewhat similar. We have used transfer learning with VGG16 and Inception V3 models which are state of the art CNN models. Our solution enables us to predict the disease by analyzing the image through a convolutional neural network (CNN) trained using transfer learning. Proposed approach achieves a commendable accuracy of 94% on the testing data and 99.94% on training dataset with just 4000 units of data, whereas to the best of our knowledge other researchers have achieved similar accuracies using a substantially larger (almost 10 times) dataset.

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References

  1. Brezinski, M.E., Fujimoto, J.G.: Optical coherence tomography: high-resolution imaging in nontransparent tissue. IEEE J. Sel. Top. Quantum Electron. 5(4), 1185–1192 (1999)

    Article  Google Scholar 

  2. Hunter, A.A., Chin, E.K., Almeida, D.R., Telander, D.G.: Drusen imaging: a review. J. Clin. Exp. Ophthalmol. 5(327), 2 (2014)

    Google Scholar 

  3. Amaro, M.H., Holler, A.B.: Age-related macular degeneration with choroidal neovascularization in the setting of pre-existing geographic atrophy and ranibizumab treatment. Analysis of a case series and revision paper. Revista Brasileira de Oftalmologia 71(6), 407–411 (2012)

    Article  Google Scholar 

  4. Bressler, N., et al.: Optimizing management of diabetic macular edema in Hong Kong: a collaborative position paper. Hong Kong J. Ophthalmol. 21(2), 59–64 (2017)

    Google Scholar 

  5. Kumar, S., Kumar, M.: A study on the image detection using convolution neural networks and TensorFlow. In: 2018 International Conference on Inventive Research in Computing Applications (ICIRCA), pp. 1080–1083. IEEE (2018)

    Google Scholar 

  6. Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)

  7. Szegedy, C., et al.: Going deeper with convolutions. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 1–9 (2015)

    Google Scholar 

  8. Pan, S.J., Yang, Q.: A survey on transfer learning. IEEE Trans. Knowl. Data Eng. 22(10), 1345–1359 (2010)

    Article  Google Scholar 

  9. de Bruijne, M.: Machine learning approaches in medical image analysis: from detection to diagnosis (2016)

    Google Scholar 

  10. Chen, M., Fang, L., Zhuang, Q., Liu, H.: Deep learning assessment of myocardial infarction from MR image sequences. IEEE Access 7, 5438–5446 (2019)

    Article  Google Scholar 

  11. Shie, C.-K., Chuang, C.-H., Chou, C.-N., Wu, M.-H., Chang, E.Y.: Transfer representation learning for medical image analysis. In: IEEE Engineering in Medicine and Biology Society, Conference, pp. 711–714 (2015)

    Google Scholar 

  12. Treder, M., Lauermann, J.L., Eter, N.: Automated detection of exudative age-related macular degeneration in spectral domain optical coherence tomography using deep learning. Graefe’s Arch. Clin. Exp. Ophthalmol. 256(2), 259–265 (2018)

    Article  Google Scholar 

  13. Prahs, P., et al.: OCT-based deep learning algorithm for the evaluation of treatment indication with anti-vascular endothelial growth factor medications. Graefe’s Arch. Clin. Exp. Ophthalmol. 256(1), 91–98 (2018)

    Article  Google Scholar 

  14. Kermany, D.S., et al.: Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell 172(5), 1122–1131 (2018)

    Article  Google Scholar 

  15. Cell. http://www.cell.com/cell/fulltext/S0092-8674(18)30154-5

  16. Kingma, D.P., Ba, J.: Adam: a method for stochastic optimization. arXiv preprint arXiv:1412.6980 (2014)

  17. Srivastava, N., Hinton, G., Krizhevsky, A., Sutskever, I., Salakhutdinov, R.: Dropout: a simple way to prevent neural networks from overfitting. J. Mach. Learn. Res. 15(1), 1929–1958 (2014)

    MathSciNet  MATH  Google Scholar 

  18. Towards Datascience. https://towardsdatascience.com

  19. Prechelt, L.: Early stopping - but when? In: Orr, Genevieve B., Müller, K.-R. (eds.) Neural Networks: Tricks of the Trade. LNCS, vol. 1524, pp. 55–69. Springer, Heidelberg (1998). https://doi.org/10.1007/3-540-49430-8_3

    Chapter  Google Scholar 

  20. Long, J., Shelhamer, E., Darrell, T.: Fully convolutional networks for semantic segmentation. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 3431–3440 (2015)

    Google Scholar 

  21. Van Engelen, A., et al.: Multi-center MRI carotid plaque component segmentation using feature normalization and transfer learning. IEEE Trans. Med. Imaging 34(6), 1294–1305 (2015)

    Article  Google Scholar 

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Correspondence to Arka Bhowmik , Sanjay Kumar or Neeraj Bhat .

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Bhowmik, A., Kumar, S., Bhat, N. (2019). Eye Disease Prediction from Optical Coherence Tomography Images with Transfer Learning. In: Macintyre, J., Iliadis, L., Maglogiannis, I., Jayne, C. (eds) Engineering Applications of Neural Networks. EANN 2019. Communications in Computer and Information Science, vol 1000. Springer, Cham. https://doi.org/10.1007/978-3-030-20257-6_9

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  • DOI: https://doi.org/10.1007/978-3-030-20257-6_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-20256-9

  • Online ISBN: 978-3-030-20257-6

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