Abstract
TTP is a type of thrombotic microangiopathy characterized by low platelets and evidence of a microangiopathic hemolytic anemia which produces platelet plugs and resultant red cell debris (called schistocytes). The underlying cause can be idiopathic or it can result from acquired antibodies to a protein called ADAMTS13 which serves to cleave von Willebrand multimers. TTP may also cause neurological abnormalities and less commonly renal failure. Definitive treatment is with plasmapheresis. It can cause a waxing and waning disease pattern. Untreated, the mortality is over 80%.
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Joshua Faucher: No disclosures.
Colin Kaide: Callibra, Inc.-Discharge 123 medical software company. Medical Advisory Board Portola Pharmaceuticals. I have no relationship with a commercial company that has a direct financial interest in subject matter or materials discussed in article or with a company making a competing product.
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Faucher, J., Kaide, C.G. (2020). Thrombotic Thrombocytopenia Purpura (TTP): “Who Are You Calling a FAT RN?” . In: Kaide, C., San Miguel, C. (eds) Case Studies in Emergency Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-22445-5_58
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