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Molecular Biomarkers for the Management of Colorectal Cancer Liver Metastases

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Colorectal Cancer Liver Metastases

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Abstract

Prognostic biomarkers for patients with colorectal cancer liver metastases (CRLM) have historically consisted of traditional clinicopathologic variables such as tumor size and focality, primary colon cancer nodal status, disease-free interval, and serum CEA level. Given the high risk of recurrence even after margin-negative resection for CRLM, these variables have been used to guide patient selection, treatment decisions, risk stratification, and prognostication. A better understanding of the molecular pathways underlying the development and metastasis of colorectal cancer has led to identification of mutations in KRAS, BRAF, PIK3CA, APC, and P53 genes and the presence of microsatellite instability (MSI) as important prognostic molecular biomarkers. In the near future, these biomarkers may be routinely used for guiding patient selection for surgical resection of CRLM, the choice and timing of systemic therapy, the sequencing of treatments, and individualizing patient-specific risk of recurrence and disease-related mortality.

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Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    Malcolm H. Squires III, Jordan M. Cloyd & Timothy M. Pawlik

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  1. Malcolm H. Squires III
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  2. Jordan M. Cloyd
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  3. Timothy M. Pawlik
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Correspondence to Timothy M. Pawlik .

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Editors and Affiliations

  1. National Cancer Institute, Rio de Janeiro, Brazil

    Mauro Monteiro Correia

  2. Banner MD Anderson Cancer Center, Phoenix, AZ, USA

    Michael A. Choti

  3. Virginia Mason Medical Center, Seattle, WA, USA

    Flavio G. Rocha

  4. Center for Advanced Treatment of HBP Diseases, Ageo Central General Hospital, Ageo Shi, Saitama, Japan

    Go Wakabayashi

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Squires, M.H., Cloyd, J.M., Pawlik, T.M. (2020). Molecular Biomarkers for the Management of Colorectal Cancer Liver Metastases. In: Correia, M., Choti, M., Rocha, F., Wakabayashi, G. (eds) Colorectal Cancer Liver Metastases. Springer, Cham. https://doi.org/10.1007/978-3-030-25486-5_3

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