Abstract
This paper assesses the initial collateral effects which result from the use of electromagnetic (EM) hyperthermia treatment. In this particular case, the focus of study is breast cancer treatment by means of an electromagnetic simulation model. A breast model was created by using the electrical properties to tissues, and it was radiated with three applicators at 2.45 GHz to generate increased of temperature, analyzing the distribution of power density inside the breast. The third applicator, it is a new applicator developed in the Groove Gap Waveguide technology (GGW). A comparison between the power density in the tumor and other breast tissues (fat and lobes) is presented. Results show that the location of the microwave applicator is a factor that determines the unwanted overheating of tissues closed tumor. The preliminary results indicate that with the new applicator developed in the Groove Gap Waveguide technology (GGW) is possible to focus the EM energy. Moreover, the tissues close to the tumor obtain a lower concentration of power density.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
W. International, “World Cancer Research Fund,” Breast cancer statistics. https://www.wcrf.org/dietandcancer/cancer-trends/breast-cancer-statistics
Chicheł, A., Skowronek, J., Kubaszewska, M., Kanikowski, M.: Hyperthermia - description of a method and a review of clinical applications. Reports Pract. Oncol. Radiother. 12(5), 267–275 (2007)
Lee, T.H., Bu, J., Kim, B.H., Poellmann, M.J., Hong, S., Hyun, S.H.: Sub-lethal hyperthermia promotes epithelial-to-mesenchymal-like transition of breast cancer cells: implication of the synergy between hyperthermia and chemotherapy. RSC Adv. 9(1), 52–57 (2019)
Nguyen, P.T., Abbosh, A.M.: Focusing techniques in breast cancer treatment using non-invasive microwave hyperthermia. In: ISAP 2015, pp. 1–3 (2015)
Iero, D.A.M., Crocco, L., Isernia, T., Korkmaz, E.: Optimal focused electromagnetic hyperthermia treatment of breast cancer. In: 2016 10th European Conference on Antennas Propagation, EuCAP 2016, pp. 1–2 (2016)
Merunka, I., Fiser, O., Vojackova, L., Vrba, J., Vrba, D.: Utilization potential of balanced antipodal Vivaldi antenna for microwave hyperthermia treatment of breast cancer. In: 8th European Conference on Antennas Propagation, EuCAP 2014, vol. 6, pp. 706–710 (2014)
Vander Vorst, A., Rosen, A., Kotsuka, Y.: RF/Microwave Interaction with Biological Tissues. Wiley, Hoboken (2006)
Garaj-Vrhovac, V., Fucic, A., Horvat, D.: The correlation between the frequency of micronuclei and specific chromosome aberrations in human lymphocytes exposed to microwave radiation in vitro. Mutat. Res. 281, 181–186 (1992)
Tamburello, C.C., Zanforlin, L., Tiné, G., Tamburello, A.E.: Analysis of microwave effects on isolated hearts.pdf, pp. 804–808 (1991)
Ely, T.S., Goldman, D.E., Hearon, J.Z.: Heating characteristics of laboratory animals exposed to ten-centimeter microwaves. IEEE Trans. Biomed. Eng. BME-11(4), 123–137 (1964)
Nathanson, S.D., et al.: Changes associated with metastasis in B16-F1 melanoma cells surviving heat. Arch. Surg. 125(2), 216–219 (1990)
Nathanson, S.D., Nelson, L., Anaya, P., Havstad, S., Hetzel, F.W.: Development of lymph node and pulmonary metastases after local irradiation and hyperthermia of footpad melanomas. Clin. Exp. Metastasis 9(4), 377–392 (1991)
Gunderson, L.L., Tepper, J.E.: Clinical Radiation Oncology, 4th edn. Elsevier Inc., Philadelphia (2016)
Jones, E.L., et al.: Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer. Clin. Cancer Res. 10(13), 4287–4293 (2004)
Vujaskovic, Z., et al.: A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer. Int. J. Hyperth. 26(5), 514–521 (2010)
Refaat, T., et al.: Hyperthermia and radiation therapy for locally advanced or recurrent breast cancer. Breast 24(4), 418–425 (2015)
Chakaravarthi, G., Arunachalam, K.: Design and characterisation of miniaturised cavity-backed patch antenna for microwave hyperthermia. Int. J. Hyperth. 31(7), 737–748 (2015)
Yong-Xing, D., Xiao-Li, X., Li-Li, W.: The analysis and simulation of planar spiral antenna for microwave hyperthermia, pp. 1–4 (2007)
Bt Lias, K., Narihan, M.Z.A., Buniyamin, N.: An antenna with an embedded EBG structure for non invasive hyperthermia cancer treatment. In: Proceedings of the 2014 IEEE Conference on Biomedical Engineering and Sciences, IECBES 2014, “Miri, Where Engineering in Medicine and Biology and Humanity Meet,” pp. 618–621, December 2014
Vrba, D., Vrba, J.: Applicators for local microwave hyperthermia based on metamaterial technology. In: 8th European Conference on Antennas and Propagation, EuCAP 2014, pp. 68–71 (2014)
Curto, S., Ruvio, G., Ammann, M.J., Prakash, P.: A wearable applicator for microwave hyperthermia of breast cancer: performance evaluation with patient-specific anatomic models. In: Proceedings of the 2015 International Conference on Electromagnetics in Advanced Applications, ICEAA 2015, pp. 1159–1162 (2015)
Guarnizo Mendez, H.F., Polochè Arango, M.A., Pantoja Acosta, J.J.: Hyperthermia study in breast cancer treatment. In: Figueroa-García, J.C., Villegas, Juan G., Orozco-Arroyave, J.R., Maya Duque, P.A. (eds.) WEA 2018, Part II. CCIS, vol. 916, pp. 256–267. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00353-1_23
Nguyen, P.T., Abbosh, A.M., Crozier, S.: Realistic simulation environment to test microwave hyperthermia treatment of breast cancer. In: IEEE Antennas and Propagation Society AP-S International Symposium, pp. 1188–1189 (2014)
Korkmaz, E., Isık, O., Sagkol, H.: A directive antenna array applicator for focused electromagnetic hyperthermia treatment of breast cancer. In: 2015 9th European Conference on Antennas and Propagation, vol. 1, pp. 1–4 (2015)
Porter, E., Fakhoury, J., Oprisor, R., Coates, M., Popovic, M.: Improved tissue phantoms for experimental validation of microwave breast cancer detection. In: 2010 Proceedings of the Fourth European Conference on Antennas and Propagation (EuCAP), pp. 4–8 (2010)
Nikita, K.S. (ed.): Handbook of Biomedical Telemetry. Wiley, Hoboken (2014)
Bohórquez, J.C., et al.: Planar substrate integrated waveguide cavity-backed antenna. IEEE Antennas Wirel. Propag. Lett. 8, 1139–1142 (2009)
Boria, V.E., Sánchez-Escuderos, D., Bernardo-Clemente, B., Berenguer, A., Baquero-Escudero, M.: Groove gap waveguide as an alternative to rectangular waveguide for H-plane components. Electron. Lett. 52(11), 939–941 (2016)
Nawaz, M.I., Huiling, Z., Kashif, M.: Substrate integrated waveguide (SIW) to microstrip transition at X-Band. In: 2014 International Conference on Circuits, Systems and Control, pp. 61–63 (2014)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this paper
Cite this paper
Guarnizo Mendez, H.F., Polochè Arango, M.A., Pantoja Acosta, J.J., Coronel Rico, J.F., Amaya Opayome, J.S. (2019). Hyperthermia Study in Breast Cancer Treatment Using Three Applicators. In: Figueroa-García, J., Duarte-González, M., Jaramillo-Isaza, S., Orjuela-Cañon, A., Díaz-Gutierrez, Y. (eds) Applied Computer Sciences in Engineering. WEA 2019. Communications in Computer and Information Science, vol 1052. Springer, Cham. https://doi.org/10.1007/978-3-030-31019-6_36
Download citation
DOI: https://doi.org/10.1007/978-3-030-31019-6_36
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-31018-9
Online ISBN: 978-3-030-31019-6
eBook Packages: Computer ScienceComputer Science (R0)