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Sexual Dimorphism of the Adult Human Retina Assessed by Optical Coherence Tomography

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XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019 (MEDICON 2019)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 76))

Abstract

In this work, we imaged the retina of healthy age-matched female and male subjects with optical coherence tomography to assess the existence of localised sex-related differences in the retina. Texture analysis revealed statistically significant differences spread over the different layers of the neuroretina, particularly at the ganglion cell, inner plexiform and inner nuclear layers, and also spread in the macula. These results suggest that sexual dimorphism is expressed in the retina at the microstructural level.

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References

  1. Bernardes, R., Silva, G., Chiquita, S., Serranho, P., Ambrósio, A.F.: Retinal biomarkers of Alzheimer’s disease: insights from transgenic mouse models. In: 14th International Conference on Image Analysis and Recognition (ICIAR) (2017). https://doi.org/10.1007/978-3-319-59876-5_60

    Google Scholar 

  2. Celik, T., Tjahjadi, T.: Multiscale texture classification using dual-tree complex wavelet transform. Pattern Recognit. Lett. 30, 331–339 (2009). https://doi.org/10.1016/j.patrec.2008.10.006

    Article  Google Scholar 

  3. Clausi, D.A.: An analysis of co-occurrence texture statistics as a function of grey level quantization. Can. J. Remote Sensing 28(1), 45–62 (2002). https://doi.org/10.5589/m02-004

    Article  Google Scholar 

  4. Çubuk, M., Kasım, B., Koçluk, Y., Sukgen, E.A.: Effects of age and gender on macular thickness in healthy subjects using spectral optical coherence tomography/scanning laser ophthalmoscopy. Int. Ophthalmol. 38(1), 127–131 (2018). https://doi.org/10.1007/s10792-016-0432-z

    Article  Google Scholar 

  5. Guimarães, P., Rodrigues, P., Lobo, C., Leal, S., Figueira, J., Serranho, P., Bernardes, R.: Ocular fundus reference images from optical coherence tomography. Comput. Med. Imaging Graph. 38, 381–389 (2014). https://doi.org/10.1016/j.compmedimag.2014.02.003

    Article  Google Scholar 

  6. Haralick, R.M., Shanmugam, K., Dinstein, I.: Textural features for image classification. IEEE Trans. Syst. Man Cybern. SMC–3(6), 610–621 (1973). https://doi.org/10.1109/TSMC.1973.4309314

    Article  Google Scholar 

  7. Nunes, A., Ambrósio, A.F., Castelo-Branco, M., Bernardes, R.: Texture biomarkers of Alzheimer’s disease and disease progression in the mouse retina. In: IEEE International Conference on Bioinformatics and Bioengineering, pp. 41–46 (2018). https://doi.org/10.1109/BIBE.2018.00016

  8. Nuzzi, R., Scalabrin, S., Becco, A., Panzica, G.: Gonadal hormones and retinal disorders: a review. Front. Endocrinol. 9(6) (2018). https://doi.org/10.3389/fendo.2018.00066

  9. Ooto, S., Hangai, M., Tomidokoro, A., Saito, H., Araie, M., Otani, T., Kishi, S., Matsushita, K., Maeda, N., Shirakashi, M., Abe, H., Ohkubo, S., Sugiyama, K., Iwase, A., Yoshimura, N.: Effects of age, sex, and axial length on the three-dimensional profile of normal macular layer structures. Invest. Ophthalmol. Vis. Sci. 52(12), 8769–8779 (2011). https://doi.org/10.1167/iovs.11-8388

    Article  Google Scholar 

  10. Soh, L.k., Tsatsoulis, C.: Texture representation of SAR sea ice imagery using multi-displacement co-occurrence matrices. In: International Geoscience and Remote Sensing Symposium (1996). https://doi.org/10.1109/IGARSS.1996.516261

  11. World Medical Association: Declaration of Helsinki - ethical principles for medical research involving human dubjects. J. Am. Med. Assoc. 310(20), 2191–2194 (2013). https://doi.org/10.3917/jib.151.0124

    Article  Google Scholar 

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Funding

This study was supported by The Portuguese Foundation for Science and Technology (PEst-UID/NEU/04539/2019), by FEDER-COMPETE (POCI-01-0145-FEDER-007440 and POCI01-0145-FEDER-016428), and by Centro 2020 FEDER-COMPETE (BIGDATIMAGE, CENTRO-01-0145-FEDER-000016).

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Authors and Affiliations

  1. Coimbra Institute for Biomedical Imaging and Clinical Research (CIBIT), Institute of Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Coimbra, Portugal

    Ana Nunes, Pedro Serranho, Hugo Quental, Miguel Castelo-Branco & Rui Bernardes

  2. CNC.IBILI Consortium, University of Coimbra, Coimbra, Portugal

    Ana Nunes, Pedro Serranho, Hugo Quental, António Francisco Ambrósio, Miguel Castelo-Branco & Rui Bernardes

  3. Mathematics Section, Department of Science and Technology, Universidade Aberta, Lisbon, Portugal

    Pedro Serranho

  4. Faculty of Medicine, University of Coimbra, Coimbra, Portugal

    António Francisco Ambrósio, Miguel Castelo-Branco & Rui Bernardes

  5. Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal

    António Francisco Ambrósio

Authors
  1. Ana Nunes
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  2. Pedro Serranho
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  3. Hugo Quental
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  4. António Francisco Ambrósio
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  5. Miguel Castelo-Branco
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  6. Rui Bernardes
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Corresponding author

Correspondence to Ana Nunes .

Editor information

Editors and Affiliations

  1. University of Coimbra, Coimbra, Portugal

    Jorge Henriques

  2. Universidade do Minho, Braga, Portugal

    Nuno Neves

  3. University of Coimbra, Coimbra, Portugal

    Paulo de Carvalho

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The authors declare no conflicts of interest.

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Nunes, A., Serranho, P., Quental, H., Ambrósio, A.F., Castelo-Branco, M., Bernardes, R. (2020). Sexual Dimorphism of the Adult Human Retina Assessed by Optical Coherence Tomography. In: Henriques, J., Neves, N., de Carvalho, P. (eds) XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019. MEDICON 2019. IFMBE Proceedings, vol 76. Springer, Cham. https://doi.org/10.1007/978-3-030-31635-8_222

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  • DOI: https://doi.org/10.1007/978-3-030-31635-8_222

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-31634-1

  • Online ISBN: 978-3-030-31635-8

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