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Transcription Factor RBPJ as a Molecular Switch in Regulating the Notch Response

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Notch Signaling in Embryology and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1287))

Abstract

The Notch signal transduction cascade requires cell-to-cell contact and results in the proteolytic processing of the Notch receptor and subsequent assembly of a transcriptional coactivator complex containing the Notch intracellular domain (NICD) and transcription factor RBPJ. In the absence of a Notch signal, RBPJ remains at Notch target genes and dampens transcriptional output. Like in other signaling pathways, RBPJ is able to switch from activation to repression by associating with corepressor complexes containing several chromatin-modifying enzymes. Here, we focus on the recent advances concerning RBPJ-corepressor functions, especially in regard to chromatin regulation. We put this into the context of one of the best-studied model systems for Notch, blood cell development. Alterations in the RBPJ-corepressor functions can contribute to the development of leukemia, especially in the case of acute myeloid leukemia (AML). The versatile role of transcription factor RBPJ in regulating pivotal target genes like c-MYC and HES1 may contribute to the better understanding of the development of leukemia.

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Abbreviations

ADAM:

A disintegrin and metalloproteinase

AE:

AML1/ETO

AE9a:

AML1/ETO 9a

AEtr:

AML1/ETO truncated

AF9:

ALL1-fused gene from chromosome 9 protein

AMKL:

Acute megakaryoblastic leukemia

AML:

Acute myeloid leukemia

AML1:

Acute myeloid leukemia 1

ANKs:

Ankyrin repeats

B-ALL:

B-cell acute lymphoblastic leukemia

CARM1:

Coactivator-associated arginine methyltransferase 1

CBF1:

C promoter-binding factor 1

CBFβ:

Core-binding factor β

CDK8:

Cyclin-dependent kinase 8

CKII:

Casein kinase II

CLL:

Chronic lymphocytic leukemia

CoA:

Coactivator

CoR:

Corepressor

CSL:

Homo sapiens CBF1, Drosophila melanogaster Suppressor of Hairless, and Caenorhabditis elegans Lag-1

CtBP:

C-terminal-binding protein

CtIP:

CtBP-interacting protein

DDX5:

DEAD-box helicase 5

DLBCL:

Diffuse large B-cell lymphoma

DLL1:

DELTA-LIKE 1

DLL4:

DELTA-LIKE 4

dnMAML1:

dominant-negative MAML1

EBNA2:

Epstein-Barr virus nuclear antigen 2

EGR2 :

Early growth response 2

Ep300:

E1A-binding protein P300

Ep400:

E1A-binding protein P400

ESCs:

Embryonic stem cells

ETO:

Eight-twenty-one

FBXW7:

F-Box and WD repeat domain-containing 7

FHL1C:

Four-and-a-half LIM domain protein 1C

FLT3:

FMS-like tyrosine kinase 3

GCN5:

General control of amino acid synthesis protein 5-like 2

GoF:

Gain of function

GSI:

γ-secretase inhibitor

H2A.Zac:

H2A.Z acetylation

HAT:

Histone acetyltransferase

HD:

heterodimerization domain

HDACs:

Histone deacetylases

Hes1 :

Hairy and Enhancer of Split 1

HPCs:

Hematopoietic progenitor cells

KAT:

lysine acetyltransferase

KAT2A:

lysine acetyltransferase 2A

KAT2B:

lysine acetyltransferase 2B

KAT3B:

lysine acetyltransferase 3B

KAT5:

lysine acetyltransferase 5

KBF2:

H-2 K binding factor-2

KDM1A:

lysine demethylase 1A

KDM5A:

lysine demethylase 5A

KDM7B:

lysine demethylase 7B

KMT2A:

lysine-specific methyltransferase 2A

KMT2D:

lysine-specific methyltransferase 2D

L3MBTL3:

lethal (3) malignant brain tumor-like protein 3

LID:

Little imaginal discs

LoF:

Loss of function

LSD1:

lysine-specific demethylase 1

Lz:

Lozenge

MAL:

Megakaryocytic acute leukemia

MAM:

Mastermind

MAML:

Mastermind-like

MCL:

Mantle cell lymphomas

MINT:

MSX2-interacting protein

MKL1:

Megakaryoblastic leukemia 1

MLL:

Mixed-lineage leukemia

MS:

Mass spectrometry

MTG16:

Myeloid translocation gene on chromosome 16 protein

MTG8:

Myeloid translocation gene on 8q22

MTGR1:

Myeloid translocation gene-related protein 1

NACK:

Notch activation complex kinase

NCoR:

Nuclear receptor corepressor

NFAT:

Nuclear factor of activated T-cells

NF-κB1:

Nuclear factor kappa B subunit 1

NHR:

Nervy homology regions

NICD:

NOTCH intracellular domain

NICD1:

NOTCH1 intracellular domain 1

NK:

Natural killer

OTT:

One twenty-two

PCAF:

Ep300-CBP-associated factors

PEST:

Proline, glutamic acid, serine, and threonine

PHF8:

PHD finger protein 8

PRMT4:

Protein arginine methyltransferase 4

PTMs:

Posttranslational modifications

RBM15:

RNA-binding motif protein 15

RBPID:

RBPJ-interacting domain

RBPJ:

Recombination signal-binding protein for immunoglobulin kappa J region

RBS:

RBPJ-binding sites

RHD:

Runt homology domain

Runx:

Runt-related transcription factor

RUNX1:

Runt-related transcription factor 1

SHARP:

SMRT and HDACs-associated repressor protein

SMRT:

Silencing mediator for retinoid and thyroid receptor

SMZL:

Splenic marginal zone lymphomas

Spen:

split ends

SPOC:

Spen paralog and ortholog C-terminal

SPOCome:

SPOC interactome

SRA :

Steroid receptor coactivator

SuH:

Suppressor of Hairless

TAD:

Transactivation domain

T-ALL:

T-cell acute lymphoblastic leukemia

TFs:

transcription factors

Tip60:

HIV-1 Tat-interactive protein, 60 kDa

UTR:

Untranslated region

WT:

Wild type

ZnF:

Zinc fingers

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Acknowledgments

This work was supported by the collaborative research grant TRR81 and the Heisenberg program (BO 1639/5-1) by the DFG (German Research Foundation) and the Excellence Cluster for Cardio Pulmonary System (ECCPS) in Giessen to T.B. Funding for open access charge was provided by the DFG collaborative research TRR81. B.D.G. is supported by a Research Grant of the University Medical Center Giessen and Marburg (UKGM).

Competing Interests

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Institute of Biochemistry, University of Giessen, Giessen, Germany

    Benedetto Daniele Giaimo & Tilman Borggrefe

  2. Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Ellen K. Gagliani & Rhett A. Kovall

Authors
  1. Benedetto Daniele Giaimo
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  2. Ellen K. Gagliani
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  3. Rhett A. Kovall
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  4. Tilman Borggrefe
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Corresponding authors

Correspondence to Benedetto Daniele Giaimo or Tilman Borggrefe .

Editor information

Editors and Affiliations

  1. Department of Dermatology, Saarland University Medical Center, Homburg, Saarland, Germany

    Jörg Reichrath

  2. Department of Dermatology, Saarland University Medical Center, Homburg, Saarland, Germany

    Sandra Reichrath

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Giaimo, B.D., Gagliani, E.K., Kovall, R.A., Borggrefe, T. (2021). Transcription Factor RBPJ as a Molecular Switch in Regulating the Notch Response. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 1287. Springer, Cham. https://doi.org/10.1007/978-3-030-55031-8_2

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