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Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer

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Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1308))

Abstract

Phytochemicals are various compounds produced by plants. There is growing evidence on their potential health effects. Some of these compounds are considered as traditional medicines and used as painkillers, anti-inflammatory agents, and for other applications. One of these phytochemicals is curumin, a natural polyphenol derived from the turmeric plant (Curcuma longa L.). Curcumin is widely used as a food coloring, preservative and condiment. It has also been shown to have antioxidative and anti-inflammatory effects. Moreover, there is growing evidence that curcumin alters long noncoding RNAs (lncRNAs) in many kinds of cancer. These noncoding RNAs can cause epigenetic modulation in the expression of several genes. This study reviews reports of curcumin effects on lncRNAs in lung, prostate, colorectal, breast, pancreatic, renal, gastric, and ovarian cancers.

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Competing Interests

Muhammed Majeed is the founder of Sabinsa Corporation and Sami Labs Ltd. The authors have no other conflicting interests to disclose.

Author information

Authors and Affiliations

  1. Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran

    Abolfazl Amini

  2. Department of Medical Biotechnology, Faculty of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran

    Abolfazl Amini & Parand Khadivar

  3. Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran

    Ali Ahmadnia

  4. Dentistry School, Tabriz University of Medical Sciences, Tabriz, Iran

    Morteza Alipour

  5. Sabinsa Corporation, East Windsor, NJ, USA

    Muhammed Majeed

  6. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran

    Tannaz Jamialahmadi

  7. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Tannaz Jamialahmadi

  8. Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK

    Thozhukat Sathyapalan

  9. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  10. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  11. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  12. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

    Amirhossein Sahebkar

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  1. Abolfazl Amini
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  2. Parand Khadivar
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  3. Ali Ahmadnia
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  4. Morteza Alipour
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  5. Muhammed Majeed
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  7. Thozhukat Sathyapalan
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  8. Amirhossein Sahebkar
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Correspondence to Amirhossein Sahebkar .

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Editors and Affiliations

  1. Department of Biological Sciences, University of Limerick, Limerick, Ireland

    George E. Barreto

  2. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

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Amini, A. et al. (2021). Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer. In: Barreto, G.E., Sahebkar, A. (eds) Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Advances in Experimental Medicine and Biology, vol 1308. Springer, Cham. https://doi.org/10.1007/978-3-030-64872-5_2

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