Skip to main content

Bone Age Assessment for Lower Age Groups Using Triplet Network in Small Dataset of Hand X-Rays

  • Conference paper
  • First Online:
Intelligent Human Computer Interaction (IHCI 2020)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 12615))

Included in the following conference series:

  • 1284 Accesses

Abstract

Skeletal Bone age assessment is a routine clinical procedure carried out by paediatricians and endocrinologists for investigating a variety of endocrinological, metabolic, genetic and growth disorders in children. Skeletal maturity advances with change in structure and size of the skeletal bones with respect to age. This is commonly done by radiological investigation of the left hand due to its non dominant use. Dissent in the skeletal age and bone age values indicates abnormality. In this study, a bone-age assessment model using triplet loss for children in 0–3 years of age is proposed. Furthermore, this is the first automated bone age assessment study on lower age groups with comparable results, using one tenth of the training data samples as opposed to conventional deep neural networks. We have used small number of radiographs per class from Digital Hand Atlas Database System (DHA), a publicly available comprehensive x-ray dataset. Model trained achieves an AUC of 0.92 for binary and 0.82 for multi-class classification with visible separation in embedding clusters; thereby resulting in correct predictions on test data set.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Gilsanz, V., Ratib, O.: Hand Bone Age: A Digital Atlas of Skeletal Maturity, p. 106. Springer, Heidelberg (2005). https://doi.org/10.1007/b138568

    Book  Google Scholar 

  2. Krakow, D., Rimoin, D.L.: The skeletal dysplasias. Genet. Med. 12, 327–341 (2010)

    Article  Google Scholar 

  3. Parnell, S., Phillips, G.: Neonatal skeletal dysplasias. Pediatr. Radiol. 42(Suppl 1), S150–S157 (2012). https://doi.org/10.1007/s00247-011-2176-2

    Article  Google Scholar 

  4. Greulich, W.W., Pyle, S.I.: Radiographic Atlas of Skeletal Development of the Hand and Wrist. Stanford University Press, Stanford (1959)

    Book  Google Scholar 

  5. Malina, R.M., Beunen, G.P.: Assessment of skeletal maturity and prediction of adult height (TW3 method). Am. J. Hum. Biol. 14, 788–789 (2002)

    Article  Google Scholar 

  6. Thodberg, H.H., Kreiborg, S., Juul, A., Pedersen, K.D.: The BoneXpert method for automated determination of skeletal maturity. IEEE Trans. Med. Imaging 28(1), 52–66 (2009)

    Article  Google Scholar 

  7. O’Connor, J.E., Coyle, J., Bogue, C., Spence, L.D., Last, J.: Age prediction formulae from radiographic assessment of skeletal maturation at the knee in an Irish population. Forensic Sci. Int. 234(188), e1–8 (2014)

    Google Scholar 

  8. Cunha, P., Moura, D.C., Guevara Lopez, M.A., Guerra, C., Pinto, D., Ramos, I.: Impact of ensemble learning in the assessment of skeletal maturity. J. Med. Syst. 38, 87 (2014). https://doi.org/10.1007/s10916-014-0087-0

    Article  Google Scholar 

  9. Urschler, M., Grassegger, S., Stern, D.: What automated age estimation of hand and wrist MRI data tells us about skeletal maturation in male adolescents. Ann. Hum. Biol. 42(4), 358–367 (2015)

    Article  Google Scholar 

  10. Franklin, D., Flavel, A.: CT evaluation of timing for ossification of the medial clavicular epiphysis in a contemporary Western Australian population. Int. J. Legal Med. 129(3), 583–594 (2014). https://doi.org/10.1007/s00414-014-1116-8

    Article  Google Scholar 

  11. Pinchi, V., et al.: Combining dental and skeletal evidence in age classification: pilot study in a sample of Italian sub-adults. Leg. Med. 20, 75–9 (2016)

    Article  Google Scholar 

  12. Hyunkwang, L., Shahein, T., Giordano, S., et al.: Fully automated deep learning system for bone age assessment. J. Digit. Imaging 30, 427–441 (2017). https://doi.org/10.1007/s10278-017-9955-8

    Article  Google Scholar 

  13. Shi, L., Jiang, F., Ouyang, F., Zhang, J., Wang, Z., Shen, X.: DNA methylation markers in combination with skeletal and dental ages to improve age estimation in children. Forensic Sci. Int. Genet. 33, 1–9 (2018). https://doi.org/10.1016/j.fsigen.2017.11.005. PMID: 29172065

    Article  Google Scholar 

  14. Tang, F.H., Chan, J.L.C., Chan, B.K.L.: Accurate age determination for adolescents using magnetic resonance imaging of the hand and wrist with an artificial neural network-based approach. J. Digit. Imaging 32, 283–289 (2019). https://doi.org/10.1007/s10278-018-0135-2

    Article  Google Scholar 

  15. Ren, X., et al.: Regression convolutional neural network for automated pediatric bone age assessment from hand radiograph. IEEE J. Biomed. Health Inform. 23, 2030–2038 (2018)

    Article  Google Scholar 

  16. Iglovikov, V.I., Rakhlin, A., Kalinin, A.A., Shvets, A.A.: Paediatric bone age assessment using deep convolutional neural networks. In: Stoyanov, D., et al. (eds.) DLMIA/ML-CDS -2018. LNCS, vol. 11045, pp. 300–308. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00889-5_34

    Chapter  Google Scholar 

  17. Zhao, C., Han, J., Jia, Y., Fan, L., Gou, F.: Versatile framework for medical image processing and analysis with application to automatic bone age assessment. J. Electr. Comput. Eng. 2018, 13 (2018). Article ID 2187247

    Google Scholar 

  18. Spampinato, C., Palazzo, S., Giordano, D., et al.: Deep learning for automated skeletal bone age assessment in X-Ray images. Med. Image Anal. 36, 41–51 (2017)

    Article  Google Scholar 

  19. Hao, P., Chokuwa, S., Xie, X., Fuli, W., Jian, W., Bai, C.: Skeletal bone age assessments for young children based on regression convolutional neural networks. Math. Biosci. Eng. 16(6), 6454–6466 (2019). https://doi.org/10.3934/mbe.2019323

    Article  MathSciNet  Google Scholar 

  20. Chen, M.: Automated Bone Age Classification with Deep Neural Networks (2016)

    Google Scholar 

  21. Schroff, F., Kalenichenko, D., Philbin, J.: FaceNet: a unified embedding for face recognition and clustering, pp. 815–823 (2015). arXiv:1503.03832v3

  22. Hoffer, E., Ailon, N.: Deep metric learning using triplet network. In: Feragen, A., Pelillo, M., Loog, M. (eds.) SIMBAD 2015. LNCS, vol. 9370, pp. 84–92. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24261-3_7

    Chapter  Google Scholar 

  23. Gertych, A., Zhang, A., Sayre, J., Pospiech-Kurkowska, S., Huang, H.: Bone age assessment of children using a digital hand atlas. Comput. Med. Imaging Graph.: Off. J. Comput. Med. Imaging Soc. 31(4–5), 322–331 (2007)

    Article  Google Scholar 

  24. Zhang, A., Sayre, J.W., Vachon, L., Liu, B.J., Huang, H.K.: Racial differences in growth patterns of children assessed on the basis of bone age. Radiology 250(1), 228–235 (2009)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shipra Madan .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Madan, S., Gandhi, T., Chaudhury, S. (2021). Bone Age Assessment for Lower Age Groups Using Triplet Network in Small Dataset of Hand X-Rays. In: Singh, M., Kang, DK., Lee, JH., Tiwary, U.S., Singh, D., Chung, WY. (eds) Intelligent Human Computer Interaction. IHCI 2020. Lecture Notes in Computer Science(), vol 12615. Springer, Cham. https://doi.org/10.1007/978-3-030-68449-5_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-68449-5_15

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-68448-8

  • Online ISBN: 978-3-030-68449-5

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics