Skip to main content

Diagnosis Method of Alzheimer’s Disease in PET Image Based on CNN Multi-mode Network

  • Conference paper
  • First Online:
Human Centered Computing (HCC 2020)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 12634))

Included in the following conference series:

  • 922 Accesses

Abstract

Developing a correct diagnosis of Alzheimer’s disease (AD) is a challenging task. Positron emission tomography (PET) is a good method to help doctors assist in the diagnosis of AD. In recent years, artificial intelligence methods such as machine learning have been widely used in image analysis and judgment and medical auxiliary diagnosis. The current methods are mainly to manually extract image features from medical images and then train classifiers to judge AD, or use deep learning, neural networks for end-to-end AD classification, most methods only use a single-mode method, and the classification effect is limited. This paper proposes a multi-mode network structure based on CNN to classify and diagnose AD. The network is mainly divided into three parts: CNN-based multi-scale deep-level feature extraction module, image texture feature extraction module, and SVM-based feature integration classification module. The network fully combines the advantages of the two modes of manual feature extraction and neural network. Compared with single mode feature extraction, this method has higher accuracy and has a good performance on the classification and diagnosis of AD.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Pan, X., Adel, M., Fossati, C., Gaidon, T., Guedj, E.: Multilevel Feature Representation of FDG-PET Brain Images for Diagnosing Alzheimer’s Disease. IEEE J. Biomed. Health Inf. 23, 1499–1506 (2019)

    Article  Google Scholar 

  2. Reitz, C., Brayne, C., Mayeux, R.: Epidemiology of alzheimer disease. Nat. Rev. Neurol. 7, 137–152 (2011)

    Article  Google Scholar 

  3. Wortmann, M.: Dementia: a global health priority - highlights from an ADI and world health organization report. Alzheimer’s Res. Ther. 4, 40 (2012)

    Article  Google Scholar 

  4. Cheng, D., Liu, M.: Classification of Alzheimer’s disease by cascaded convolutional neural networks using PET Images. In: Wang, Q., Shi, Y., Suk, H.-I., Suzuki, K. (eds.) MLMI 2017. LNCS, vol. 10541, pp. 106–113. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-67389-9_13

    Chapter  Google Scholar 

  5. Garali, I., Adel, M., Bourennane, S., Guedj, E.: Region-based brain selection and classification on pet images for Alzheimer’s disease computer aided diagnosis. In: 2015 IEEE International Conference on Image Processing (ICIP), pp. 1473–1477. Quebec City (2015)

    Google Scholar 

  6. Serag, A., Wenzel, F., Thiele, F., Buchert, R., Young, S.: Optimal feature selection for automated classification of FDG-PET in patients with sus-pected dementia. In: Medical Imaging 2009, Florida, United States (2009)

    Google Scholar 

  7. Dhungel, N., Carneiro, G., Bradley, A.: A deep learning approach for the analysis of masses in mammograms with minimal user intervention. Med. Image Anal. 37, 114–128 (2017)

    Article  Google Scholar 

  8. Setio, A., et al.: Pulmonary Nodule detection in CT images: false positive reduction using multi-view convolutional networks. IEEE Trans. Medi. Imaging 35, 1160–1169 (2016)

    Article  Google Scholar 

  9. Xu, L., Wu, X., Chen, K., Yao, L.: Multi-modality sparse representation-based classification for Alzheimer’s disease and mild cognitive impairment. Comput. Methods Programs Biomed. 122, 182–190 (2015)

    Article  Google Scholar 

  10. Xue, Y., Zhang, R., Deng, Y., Chen, K., Jiang, T.: A preliminary examination of the diagnostic value of deep learning in hip osteoarthritis. PLoS ONE 12, e0178992 (2017)

    Article  Google Scholar 

  11. Garali, I., Adel, M., Bourennane, S., Guedj, E.: Region-based brain selection and classification on pet images for Alzheimer’s disease computer aided diagnosis. In: IEEE International Conference on Image Processing, pp. 1473–1477 (2015)

    Google Scholar 

  12. Shen, L., Xia, Y., Cai, T.W., Feng, D.D.: Semi-supervised manifold learning with affinity regularization for Alzheimer’s disease identification. In: International Conference of the IEEE EMBS, p. 2251 (2015)

    Google Scholar 

  13. Silveira, M., Marques, J.: Boosting Alzheimer disease diagnosis using PET images. In: International Conference on Pattern Recognition, pp. 2556–2559 (2010)

    Google Scholar 

  14. Cabral, C., Silveira, M.: Classification of Alzheimer’s disease from FDG-PET images using favourite class ensembles. In: Engineering in Medicine and Biology Society, pp. 2477–2480. IEEE (2013)

    Google Scholar 

  15. Vu, T., Yang, H., Nguyen, V., Oh, A., Kim, M.: Multimodal learning using convolution neural network and sparse autoencoder. In: IEEE International Conference on Big Data and Smart Computing, pp. 13–16. Jeju, South Korea (2017)

    Google Scholar 

  16. Keys, R.: Cubic convolution interpolation for digital image processing. IEEE Trans. Acoustics Speech Signal Process. 29, 1153–1160 (1981)

    Article  MathSciNet  Google Scholar 

  17. Kong, F.: Image retrieval using both color and texture features. In: 2009 International Conference on Machine Learning and Cybernetics, pp. 2228–2232. Hebei, China (2009)

    Google Scholar 

  18. Haralick, R., Shanmugam, K., Dinstein, I.: Textural features for image classification. IEEE Trans. Syst. Man Cyber. SMC-3, 610–621 (1973)

    Google Scholar 

  19. Haralick, R.: Statistical and structural approaches to texture. Proc. IEEE 67, 786–804 (1979)

    Article  Google Scholar 

  20. Nikoo, H., Talebi, H., Mirzaei, A.: A supervised method for determining displacement of gray level co-occurrence matrix. In: 7th Iranian Conference on Machine Vision and Image Processing, pp. 1–5, 16–17. (2011)

    Google Scholar 

  21. Srivastava, N., Hinton, G., Krizhevsky, A., Sutskever, I., Salakhutdinov, R.: Dropout: a simple way to prevent neural networks from overfitting. J. Mach. Learn. Res. 15(1), 1929–1958 (2014)

    MathSciNet  MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to He Huang .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Wu, S., Huang, H. (2021). Diagnosis Method of Alzheimer’s Disease in PET Image Based on CNN Multi-mode Network. In: Zu, Q., Tang, Y., Mladenović, V. (eds) Human Centered Computing. HCC 2020. Lecture Notes in Computer Science(), vol 12634. Springer, Cham. https://doi.org/10.1007/978-3-030-70626-5_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-70626-5_24

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-70625-8

  • Online ISBN: 978-3-030-70626-5

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics