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Step-by-Step Instruction: Immediate Lymphatic Reconstruction for Lymphedema Risk Reduction in Breast Cancer Management

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Multimodal Management of Upper and Lower Extremity Lymphedema

Abstract

Immediate lymphatic reconstruction (ILR) is a microsurgical technique performed at the time of axillary lymph node dissection (ALND) to reduce the risk of breast cancer-related lymphedema (BCRL). A lymphovenous anastomosis (LVA) is performed immediately following ALND under direct microscopic visualization. Results reported in the literature have demonstrated a reduced incidence of BCRL in patients who have undergone this procedure. As there is currently no cure for chronic lymphedema, ILR holds promise as an effective means of reducing the risk of developing this disease. In this chapter, we will address preoperative and postoperative considerations, as well as the surgical technique used to perform this procedure.

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References

  1. Johnson AR, Kimball S, Epstein S, Recht A, Lin SJ, Lee BT, et al. Lymphedema Incidence After Axillary Lymph Node Dissection: Quantifying the Impact of Radiation and the Lymphatic Microsurgical Preventive Healing Approach. Ann Plast Surg. 2019;82(4S Suppl 3):S234–41.

    Article  CAS  Google Scholar 

  2. Johnson AR, Singhal D. Immediate lymphatic reconstruction. J Surg Oncol. 2018;

    Google Scholar 

  3. Basta MN, Gao LL, Wu LC. Operative treatment of peripheral lymphedema: a systematic meta-analysis of the efficacy and safety of lymphovenous microsurgery and tissue transplantation. Plast Reconstr Surg. 2014;133(4):905–13.

    Article  CAS  Google Scholar 

  4. Brorson H, Svensson H. Complete reduction of lymphoedema of the arm by liposuction after breast cancer. Scand J Plast Reconstr Surg Hand Surg. 1997;31(2):137–43.

    Article  CAS  Google Scholar 

  5. Brorson H, Svensson H. Liposuction combined with controlled compression therapy reduces arm lymphedema more effectively than controlled compression therapy alone. Plast Reconstr Surg. 1998;102(4):1058–67; discussion 1068.

    Article  CAS  Google Scholar 

  6. Johnson AR, Bravo MG, Granoff MD, Kang CO, Critchlow JF, Tsai LL, et al. Flow-through omental flap for vascularized lymph node transfer: a novel surgical approach for delayed lymphatic reconstruction. Plast Reconstr Surg Glob Open. 2019;7(9):e2436.

    PubMed  PubMed Central  Google Scholar 

  7. Boccardo F, Casabona F, De Cian F, Friedman D, Villa G, Bogliolo S, et al. Lymphedema microsurgical preventive healing approach: a new technique for primary prevention of arm lymphedema after mastectomy. Ann Surg Oncol. 2009;16(3):703–8.

    Article  Google Scholar 

  8. Feldman S, Bansil H, Ascherman J, Grant R, Borden B, Henderson P, et al. Single institution experience with Lymphatic Microsurgical Preventive Healing Approach (LYMPHA) for the primary prevention of lymphedema. Ann Surg Oncol. 2015;22(10):3296–301.

    Article  Google Scholar 

  9. Hahamoff M, Gupta N, Munoz D, Lee BT, Clevenger P, Shaw C, et al. A lymphedema surveillance program for breast cancer patients reveals the promise of surgical prevention. J Surg Res. 2018;

    Google Scholar 

  10. Johnson AR, Fleishman A, Granoff MD, Shillue K, Houlihan MJ, Sharma R, et al. Evaluating the impact of immediate lymphatic reconstruction for the surgical prevention of lymphedema. Plast Reconstr Surg. 2020;

    Google Scholar 

  11. Boccardo F, Casabona F, De Cian F, DeCian F, Friedman D, Murelli F, et al. Lymphatic microsurgical preventing healing approach (LYMPHA) for primary surgical prevention of breast cancer-related lymphedema: over 4 years follow-up. Microsurgery. 2014;34(6):421–4.

    Article  Google Scholar 

  12. Johnson A, Fleishman A, Tran BN, Shillue K, Carroll B, Tsai L, et al. Developing a lymphatic surgery program: a first-year review. Plast Reconstr Surg [Internet]. 2019[cited 2020 Apr 24];144(6). Available from: insights.ovid.com

  13. Keeley V, Crooks S, Locke J, Veigas D, Riches K, Hilliam R. A quality of life measure for limb lymphoedema (LYMQOL). J Lymphoedema. 2010;5(1):26–37.

    Google Scholar 

  14. McHorney CA, Ware JE, Raczek AE. The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care. 1993;31(3):247–63.

    Article  CAS  Google Scholar 

  15. Spiguel L, Shaw C, Katz A, Guo L, Chen H-C, Lee BT, et al. Fluorescein isothiocyanate: a novel application for lymphatic surgery. Ann Plast Surg. 2017;78(6S Suppl 5):S296–8.

    Article  CAS  Google Scholar 

  16. Johnson AR, Granoff MD, Suami H, Lee BT, Singhal D. Real-time visualization of the Mascagni-Sappey pathway utilizing ICG lymphography. Cancers. 2020;12(5):1195.

    Article  Google Scholar 

  17. Johnson AR, Bravo MG, James TA, Suami H, Lee BT, Singhal D. The all but forgotten Mascagni-Sappey pathway: learning from immediate lymphatic reconstruction. J Reconstr Microsurg. 2020;36(1):28–31.

    Article  Google Scholar 

  18. Raut CP, Hunt KK, Akins JS, Daley MD, Ross MI, Singletary SE, et al. Incidence of anaphylactoid reactions to isosulfan blue dye during breast carcinoma lymphatic mapping in patients treated with preoperative prophylaxis. Cancer. 2005;104(4):692–9.

    Article  CAS  Google Scholar 

  19. Johnson AR, Asban A, Granoff MD, Kang CO, Lee BT, Chatterjee A, et al. Is immediate lymphatic reconstruction cost-effective? Ann Surg. 2019;

    Google Scholar 

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Correspondence to Dhruv Singhal .

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Granoff, M.D., Hamaguchi, R., Singhal, D. (2022). Step-by-Step Instruction: Immediate Lymphatic Reconstruction for Lymphedema Risk Reduction in Breast Cancer Management. In: Schaverien, M.V., Dayan, J.H. (eds) Multimodal Management of Upper and Lower Extremity Lymphedema. Springer, Cham. https://doi.org/10.1007/978-3-030-93039-4_23

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  • DOI: https://doi.org/10.1007/978-3-030-93039-4_23

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-93038-7

  • Online ISBN: 978-3-030-93039-4

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