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Optic Nerve Sheath Diameter for Increased Intracranial Pressure

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Neurovascular Sonography
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Abstract

Intracranial hypertension (ICH) is a neurologic emergency with high morbidity and mortality that if left untreated can result in cerebral circulatory arrest or brain death. Rapid assessment of intracranial pressure is essential in the diagnosis and management of acute intracranial insults. A recent review of the literature concluded that optic nerve sheath diameter (ONSD) and transcranial Doppler are the most superior non-invasive tools clinically proven to detect intracranial hypertension. Changes in the ONSD detected by ophthalmic ultrasound is a noninvasive, reproducible, and accurate way of diagnosing ICH in adults and children. The physiologic premise for ONSD measurements, clinical applications, equipment and supplies needed to obtain, methods for interpreting results, and limitations in obtaining ultrasound guided ONSD measurements are detailed within this chapter. A stepwise description of how to safely utilize ophthalmic ultrasound to obtain images and take measurements of the ONSD is detailed in chapter 31 of this book.

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References

  1. Karvellas CJ, Fix OK, Battenhouse H, Durkalski V, Sanders C, Lee WM, Group USALFS. Outcomes and complications of intracranial pressure monitoring in acute liver failure: a retrospective cohort study. Crit Care Med. 2014;42:1157–67.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Peck M, Wendon J, Sizer E, Auzinger G, Bernal W. Intracranial pressure monitoring in acute liver failure: a review of 10 years experience. Crit Care. 2010;14:P542.

    Article  PubMed Central  Google Scholar 

  3. Vaquero J, et al. Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy. Liver Transpl. 2005;11:1581–9.

    Article  PubMed  Google Scholar 

  4. Chau CYC, Craven CL, Rubiano AM, Adams H, Tulu S, Czosnyka M, Servadei F, Ercole A, Hutchinson PJ, Kolias AG. The evolution of the role of external ventricular drainage in traumatic brain injury. J Clin Med. 2019;8(9). Pii: E1422.

    Google Scholar 

  5. Alkhoury F, Kyriakides TC. Intracranial pressure monitoring in children with severe traumatic brain injury: National Trauma Data Bank-Based Review of outcomes. JAMA Surg. 2014;149(6):544–8.

    Article  PubMed  Google Scholar 

  6. Roumeliotis N, Pettersen G, Crevier L, Emeriaud G. ICP monitoring in children: why are we not adhering to guidelines? Childs Nerv Syst. 2015;31:2011–4.

    Article  PubMed  Google Scholar 

  7. Khan M, Shallwani H, Khan M, Shamim M. Noninvasive monitoring intracranial pressure? A review of available modalities. Surg Neurol Int. 2017;8(1):51.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Koziarz A, Sne N, Kegel F, Nath S, Badhiwala JH, Nassiri F, Mansouri A, Yang K, Zhou Q, Rice T, Faidi S, Passos E, Healey A, Banfield L, Mensour M, Kirkpatrick AW, Nassar A, Fehlings MG, Hawryluk GWJ, Almenawer SA. Bedside optic nerve ultrasonography for diagnosing increased intracranial pressure: a systematic review and meta-analysis. Ann Intern Med. 2019;171(12):896–905.

    Article  PubMed  Google Scholar 

  9. Lochner P, Czosnyka M, Naldi A, Lyros E, Pelosi P, Mathur S, Fassbender K, Robba C. Optic nerve sheath diameter: present and future perspectives for neurologists and critical care physicians. Neurol Sci. 2019;40(12):2447–57.

    Article  PubMed  Google Scholar 

  10. Newman WD, Hollman AS, Dutton GN, et al. Measurement of optic nerve sheath diameter by ultrasound: a means of detecting acute raised intracranial pressure in hydrocephalus. Br J Ophthalmol. 2002;86:1109–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Malayeri AA, Bavarian S, Mehdizadeh M. Sonographic evaluation of optic nerve diameter in children with raised intracranial pressure. J Ultrasound Med. 2005;24:143–7.

    Article  PubMed  Google Scholar 

  12. Beare NA, Kampodeni S, Glover SJ, Molyneux E, Taylor TE, Harding SP, Molyneux ME. Detection of raised intracranial pressure by ultrasound measurement of optic nerve sheath diameter in African children. Tropical Med Int Health. 2008;13(11):1400–4.

    Article  Google Scholar 

  13. Padayachy LC, Padayachy V, Galal U, Gray R, Fieggen AG. The relationship between transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) and invasively measured ICP in children: part I: repeatability, observer variability and general analysis. Childs Nerv Syst. 2016;32(10):1769–78.

    Article  PubMed  Google Scholar 

  14. Narayan V, Mohammed N, Savardekar AR, Patra DP, Notarianni C, Nanda A. Non-invasive intracranial pressure monitoring for severe traumatic brain injury in children: a concise update on current methods. World Neurosurg. 2018;114:293–300.

    Article  PubMed  Google Scholar 

  15. Raval R, Shen J, Lau D, Ferguson N, Kelly T, Daniels J, Dorotta I, Ramsingh D. Comparison of three point-of-care ultrasound views and MRI measurements for optic nerve sheath diameter: a prospective validity study. Neurocrit Care. 2020;33(1):173–81.

    Article  PubMed  Google Scholar 

  16. Liu M, Yang ZK, Yan YF, Shen X, Yao HB, Fei L, Wang ES. Optic nerve sheath measurements by computed tomography to predict intracranial pressure and guide surgery in patients with traumatic brain injury. World Neurosurg. 2020;134:e317–24.

    Article  PubMed  Google Scholar 

  17. Kang C, Min JH, Park JS, You Y, Yoo I, Cho YC, Jeong W, Ahn HJ, Ryu S, Lee J, Kim SW, Cho SU, Oh SK, Lee IH, Lee B, Lee D, Chae MK. Relationship between optic nerve sheath diameter measured by magnetic resonance imaging, intracranial pressure, and neurological outcome in cardiac arrest survivors who underwent targeted temperature management. Resuscitation. 2019;145:43–9.

    Article  PubMed  Google Scholar 

  18. Gospe SM 3rd, Amrhein TJ, Malinzak MD, Bhatti MT, Mettu P, El-Dairi MA. Magnetic resonance imaging abnormalities of the optic nerve sheath and intracranial internal carotid artery in giant cell arteritis. J Neuroophthalmol. 2020;41(1):54–9.

    Article  Google Scholar 

  19. Padayachy LC, Padayachy V, Galal U, Pollock T, Fieggen AG. The relationship between transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) and invasively measured ICP in children. Part II: age-related ONSD cut-off values and patency of the anterior fontanelle. Childs Nerv Syst. 2016;32(10):1779–85.

    Article  PubMed  Google Scholar 

  20. Ballantyne J, Hollman AS, Hamilton R, Bradnam MS, Carachi R, Young DG, Dutton GN. Transorbital optic nerve sheath ultrasonography in normal children. Clin Radiol. 1999;54(11):740–2.

    Article  CAS  PubMed  Google Scholar 

  21. Bauerle J, Schuchardt F, Schroeder L, et al. Reproducibility and accuracy of optic nerve sheath diameter assessment using ultrasound compared to magnetic resonance imaging. BMC Neurol. 2013;13:187.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Fontanel L, Pensiero S, Ronfani L, Rosolen V, Barbi E. Optic nerve sheath diameter ultrasound: optic nerve growth curve and its application to detect intracranial hypertension in children. Am J Ophthalmol. 2019;208:439.

    Article  PubMed  Google Scholar 

  23. Cleves-Bayon C. Idiopathic intracranial hypertension in children and adolescents: an update. Headache. 2018;58:485–93.

    Article  PubMed  Google Scholar 

  24. Maissan IM, Dirven PJAC, Haitsma IK, et al. Ultrasonographic measured optic nerve sheath diameter as an accurate and quick monitor for changes in intracranial pressure. J Neuro-Oncol. 2015;123:743–7.

    Google Scholar 

  25. Soliman I, Johnson GGRJ, Gillman LM, et al. New optic nerve sonography quality criteria in the diagnostic evaluation of traumatic brain injury. Crit Care Res Pract. 2018;2018:3589762.

    PubMed  PubMed Central  Google Scholar 

  26. Hansen HC, Helmke K. The subarachnoid space surrounding the optic nerves: an ultrasound study of the optic nerve sheath. Surg Radiol Anat. 1996;18(4):323–8.

    Article  CAS  PubMed  Google Scholar 

  27. Hayreh SS. Pathogenesis of oedema of the optic disc. Doc Ophthalmol. 1968;24(2):289–411.

    Article  CAS  PubMed  Google Scholar 

  28. Wilson MH, Wright A, Imray CH. Intracranial pressure at altitude. High Alt Med Biol. 2014;15:123–32.

    Article  PubMed  Google Scholar 

  29. Hansen HC, Helmke K. Validation of the optic nerve sheath response to changing cerebrospinal fluid pressure: ultrasound findings during intrathecal infusion tests. J Neurosurg. 1997;87:34–40.

    Article  CAS  PubMed  Google Scholar 

  30. Helmke K, Hansen HC. Fundamentals of transorbital sonographic evaluation of optic nerve sheath expansion under intracranial hypertension II. Patient study. Pediatr Radiol. 1996;26:706–10.

    Article  CAS  PubMed  Google Scholar 

  31. Liu D, Li Z, Zhang X, Zhao L, Jia J, Sun F, Wang Y, Ma D, Wei W. Assessment of intracranial pressure with ultrasonographic retrobulbar optic nerve sheath diameter measurement. BMC Neurol. 2017;17:188.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Lee SH, Kim HS, Yun SJ. Optic nerve sheath diameter measurement for predicting raised intracranial pressure in adult patients with severe traumatic brain injury: a meta-analysis. J Crit Care. 2020;56:182–7.

    Article  PubMed  Google Scholar 

  33. Du J, Deng Y, Li H, Qiao S, Yu M, Xu Q, Wang C. Ratio of optic nerve sheath diameter to eyeball transverse diameter by ultrasound can predict intracranial hypertension in traumatic brain injury patients: a prospective study. Neurocrit Care. 2019;31(3):594–5.

    Article  PubMed  Google Scholar 

  34. Rehman Siddiqui NU, Haque A, Abbas Q, Jurair H, Salam B, Sayani R. Ultrasonographic optic nerve sheath diameter measurement for raised intracranial pressure in a Tertiary care centre of a developing country. J Ayub Med Coll Abbottabad. 2018;30(4):495–500.

    PubMed  Google Scholar 

  35. Naldi A, et al. Ultrasonography monitoring of optic nerve sheath diameter and retinal vessels in patients with cerebral hemorrhage. J Neuroimaging. 2019;29(3):394–9.

    Article  PubMed  Google Scholar 

  36. Skoloudik D, et al. Distal enlargement of the optic nerve sheath in the hyperacute stage of intracerebral haemorrhage. Br J Ophthalmol. 2011;95:217–21.

    Article  PubMed  Google Scholar 

  37. Gokcen E, Caltekin I, Savrun A, Korkmaz H, Savrun ST, Yildirim G. Alterations in optic nerve sheath diameter according to cerebrovascular disease sub-groups. Am J Emerg Med. 2017;35:1607–11. https://doi.org/10.1016/j.ajem.2017.04.073.

    Article  PubMed  Google Scholar 

  38. Zhao L, Huang Q, Huang P, Zhao Q, Xie H, Wang R. Optic nerve sheath diameter and eyeball transverse diameter as a useful tool for the clinical prognosis in patients with stroke during hospitalization. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019;31(10):1242–6.

    PubMed  Google Scholar 

  39. Seyedhosseini J, Aghili M, Vahidi E, Shirani F. Association of optic nerve sheath diameter in ocular ultrasound with prognosis in patients presenting with acute stroke symptoms. Turk J Emerg Med. 2019;19(4):132–5.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Arthur J, Duran-Gehring P, Kumetz C, Chadwick S, McIntosh M. Cerebral venous thrombosis: an uncommon cause of papilledema on bedside ocular ultrasound. J Emerg Med. 2019;56(3):288–93.

    Article  PubMed  Google Scholar 

  41. Nischal KK, Smith DM, Losee JE. Discussion: nocturnal ultrasound measurements of optic nerve sheath diameter correlate with intracranial pressure in children with craniosynostosis. Plast Reconstr Surg. 2012;130(3):452e–4e.

    Article  CAS  PubMed  Google Scholar 

  42. Driessen C, Bannink N, Lequin M, van Veelen ML, Naus NC, Joosten KF, Mathijssen IM. Are ultrasonography measurements of optic nerve sheath diameter an alternative to funduscopy in children with syndromic craniosynostosis? J Neurosurg Pediatr. 2011;8(3):329–34.

    Article  PubMed  Google Scholar 

  43. Nabeta HW, Bahr NC, Rhein J, Fossland N, Kiragga AN, Meya DB, Dunlop SJ, Boulware DR. Accuracy of noninvasive intraocular pressure or optic nerve sheath diameter measurements for predicting elevated intracranial pressure in cryptococcal meningitis. Open Forum Infect Dis. 2014;1(3):ofu093.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Sangani SV, Parikh S. Can sonographic measurement of optic nerve sheath diameter be used to detect raised intracranial pressure in patients with tuberculous meningitis? A prospective observational study. Indian J Radiol Imaging. 2015;25(2):173–6.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Caputo ND, Fraser RM, Abdulkarim J. Posterior reversible encephalopathy syndrome presenting as papilledema. Am J Emerg Med. 2012;30(5):835.e5–7.

    Article  Google Scholar 

  46. Lochner P, Mader C, Nardone R, Cantello R, Orioli A. Brigo F usefulness of ultrasonography in posterior reversible encephalopathy syndrome. Neurol Sci. 2014 Mar;35(3):475–7.

    Article  PubMed  Google Scholar 

  47. Lochner P, Nardone R, Brigo F, Tamber MS, Zuccoli G. The diagnosis of posterior reversible encephalopathy syndrome. Lancet Neurol. 2015;14(11):1074–5.

    Article  PubMed  Google Scholar 

  48. Brzezinska R, Schumacher R. Diagnosis of elevated intracranial pressure in children with shunt under special consideration of transglobe sonography of the optic nerve. Ultraschall Med. 2002;23(5):325–32.

    Article  CAS  PubMed  Google Scholar 

  49. Ertl M, Aigner R, Krost M, Karnasova Z, Muller K, Naumann M, Schlachetzki F. Measuring changes in the optic nerve sheath diameter in patients with idiopathic normal-pressure hydrocephalus: a useful diagnostic supplement to spinal tap tests. Eur J Neurol. 2017;24(3):461–7.

    Article  CAS  PubMed  Google Scholar 

  50. Nag DS, Sahu S, Swain A, Kant S. Intracranial pressure monitoring: Gold standard and recent innovations. World J Clin Cases. 2019;7(13):1535–53.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Das MC, Srivastava A, Yadav RK, Yachha SK, Poddar U. Optic nerve sheath diameter in children with acute liver failure: a prospective observational pilot study. Liver Int. 2020;40(2):428–36.

    Article  PubMed  Google Scholar 

  52. Rajajee V, Williamson CA, Fontana RJ, Courey AJ, Patil PG. Noninvasive intracranial pressure assessment in acute liver failure. Neurocrit Care. 2018;29(2):280–90. 76.

    Article  PubMed  Google Scholar 

  53. Ganschow R, Nolkemper D, Helmke K, Harps E, Commentz JC, Broering DC, Pothmann W, Rogiers X, Hellwege HH, Burdelski M. Intensive care management after pediatric liver transplantation: a single-center experience. Pediatr Transplant. 2000;4(4):273–9.

    Article  CAS  PubMed  Google Scholar 

  54. Cornetta P, Vitiello L, De Bernardo M, Rosa N. Optic nerve sheath diameter appraisal in children affected by diabetic ketoacidosis. J Pediatr Endocrinol Metab. 2019;32(11):1203–4.

    Article  PubMed  Google Scholar 

  55. Kendir OT, Yilmaz HL, Ozkaya AK, Turan I, Gokay SS, Bilen S, Yildizdas RD, Yuksel B. Determination of cerebral edema with serial measurement of optic nerve sheath diameter during treatment in children with diabetic ketoacidosis: a longitudinal study. J Pediatr Endocrinol Metab. 2019;32(9):943–9.

    Article  PubMed  Google Scholar 

  56. Jeziorny K, Waszczykowska A, Barańska D, Szadkowska A, Młynarski W, Zmysłowska A. Can we effectively predict the occurrence of cerebral edema in children with ketoacidosis in the course of type 1 diabetes? -case report and literature review. J Pediatr Endocrinol Metab. 2020;33(2):319–22.

    Article  PubMed  Google Scholar 

  57. Jeziorny K, Niwald A, Moll A, Piasecka K, Pyziak-Skupien A, Waszczykowska A, Baranska D, Malachowska B, Szadkowska A, Mlynarski W, Zmyslowska A. Measurement of corneal thickness, optic nerve sheath diameter and retinal nerve fiber layer as potential new non-invasive methods in assessing a risk of cerebral edema in type 1 diabetes in children. Acta Diabetol. 2018;55(12):1295–301.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Ebisike PI, Habib SG, Hassan S, Suwaid MA, Hikima MS, Saleh MK, Jibo U, Yusuf L. Transorbital sonographic measurement of optic nerve sheath diameter among HIV-Positive patients in Northwestern Nigeria. Niger J Clin Pract. 2019;22(11):1570–5.

    Article  CAS  PubMed  Google Scholar 

  59. Chelly J, Deye N, Guichard JP, Vodovar D, Vong L, Jochmans S, Thieulot-Rolin N, Sy O, Serbource-Goguel J, Vinsonneau C, Megarbane B, Vivien B, Tazarourte K, Monchi M. The optic nerve sheath diameter as a useful tool for early prediction of outcome after cardiac arrest: a prospective pilot study. Resuscitation. 2016;103:7–13.

    Article  PubMed  Google Scholar 

  60. Chae MK, Ko E, Lee JH, Lee TR, Yoon H, Hwang SY, Cha WC, Shin TG, Sim MS, Jo IJ, Song KJ, Rhee JE, Jeong YK. Better prognostic value with combined optic nerve sheath diameter and grey-to-white matter ratio on initial brain computed tomography in post-cardiac arrest patients. Resuscitation. 2016;104:40–5.

    Article  PubMed  Google Scholar 

  61. Ueda T, Ishida E, Kojima Y, Yoshikawa S, Yonemoto H. Sonographic optic nerve sheath diameter: a simple and rapid tool to assess the neurologic prognosis after cardiac arrest. J Neuroimaging. 2015;25(6):927–30.

    Article  PubMed  Google Scholar 

  62. Ertl M, Weber S, Hammel G, Schroeder C, Krogias C. Transorbital sonography for early prognostication of hypoxic-ischemic encephalopathy after cardiac arrest. J Neuroimaging. 2018;28:542–8.

    Article  PubMed  Google Scholar 

  63. Wang J, Li K, Li H, Ji C, Wu Z, Chen H, Chen B. Ultrasonographic optic nerve sheath diameter correlation with ICP and accuracy as a tool for noninvasive surrogate ICP measurement in patients with decompressive craniotomy. J Neurosurg. 2019:1–7.

    Google Scholar 

  64. Kim Y, Choi S, Kang S, Park B. Propofol affects optic nerve sheath diameter less than sevoflurane during robotic surgery in the steep trendelenburg position. Biomed Res Int. 2019;2019:5617815.

    PubMed  PubMed Central  Google Scholar 

  65. Citerio G, Vascotto E, Villa F, Celotti S, Pesenti A. Induced abdominal compartment syndrome increases intracranial pressure in neurotrauma patients: a prospective study. Crit Care Med. 2001;29(7):1466–71.

    Article  CAS  PubMed  Google Scholar 

  66. Cooke SJ, Paterson-Brown S. Association between laparoscopic abdominal surgery and postoperative symptoms of raised intracranial pressure. Surg Endosc. 2001;15(7):723–5.

    Article  CAS  PubMed  Google Scholar 

  67. Kim MS, Bai SJ, Lee JR, Choi YD, Kim YJ, Choi SH. Increase in intracranial pressure during carbon dioxide pneumoperitoneum with steep trendelenburg positioning proven by ultrasonographic measurement of optic nerve sheath diameter. J Endourol. 2014;28(7):801–6.

    Article  PubMed  Google Scholar 

  68. Robba C, Cardim D, Donnelly J, Bertuccio A, Bacigaluppi S, Bragazzi N, Cabella B, Liu X, Matta B, Lattuada M, Czosnyka M. Effects of pneumoperitoneum and Trendelenburg position on intracranial pressure assessed using different non-invasive methods. Br J Anaesth. 2016;117(6):783–91.

    Article  CAS  PubMed  Google Scholar 

  69. Kim EJ, Koo BN, Choi SH, Park K, Kim MS. Ultrasonographic optic nerve sheath diameter for predicting elevated intracranial pressure during laparoscopic surgery: a systematic review and meta-analysis. Surg Endosc. 2018;32(1):175–82.

    Article  PubMed  Google Scholar 

  70. Ertl M, Schierling W, Kasprzak P, Schomig B, Bruckl C, Schlachetzki F, Pfister K. Optic nerve sheath diameter measurement to identify high-risk patients for spinal ischemia after endovascular thoracoabdominal aortic aneurysm repair. J Neuroimaging. 2015;25(6):910–5.

    Article  PubMed  Google Scholar 

  71. Dip F, Nguyen D, Rosales A, Sasson M, Lo Menzo E, Szomstein S, Rosenthal R. Impact of controlled intraabdominal pressure on the optic nerve sheath diameter during laparoscopic procedures. Surg Endosc. 2016;30(1):44–9.

    Article  PubMed  Google Scholar 

  72. Yu J, Park JY, Kim DH, Koh GH, Jeong W, Kim E, Hong JH, Hwang JH, Kim YK. Dexmedetomidine attenuates the increase of ultrasonographic optic nerve sheath diameter as a surrogate for intracranial pressure in patients undergoing robot-assisted laparoscopic prostatectomy: a randomized double-blind controlled trial. Medicine (Baltimore). 2019;98(33):e16772.

    Article  CAS  Google Scholar 

  73. Yoon SB, Ji SH, Jang YE, Lee JH, Kim EH, Kim JT, Kim HS. Effects of prone positioning with neck extension on intracranial pressure according to optic nerve sheath diameter measured using ultrasound in children. Childs Nerv Syst. 2020;36(5):1001–7.

    Article  PubMed  Google Scholar 

  74. Singh S, Nasa V, Tandon M. Perioperative monitoring in liver transplant patients. J Clin Exp Hepatol. 2012;2(3):271–8.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Pal A, Dhar P, Goyal N. Perioperative monitoring of intracranial pressure using optic nerve sheath diameter in paediatric liver transplantation. Indian J Anaesth. 2018;62(11):892–5.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Seo H, Kim YK, Shin WJ, Hwang GS. Ultrasonographic optic nerve sheath diameter is correlated with arterial carbon dioxide concentration during reperfusion in liver transplant recipients. Transplant Proc. 2013;45(6):2272–6.

    Article  CAS  PubMed  Google Scholar 

  77. Dubost C, Le Gouez A, Jouffroy V, Roger-Christoph S, Benhamou D, Mercier FJ, Geeraerts T. Optic nerve sheath diameter used as ultrasonographic assessment of the incidence of raised intracranial pressure in preeclampsia: a pilot study. Anesthesiology. 2012;116(5):1066–71.

    Article  PubMed  Google Scholar 

  78. Brzan Simenc G, Ambrozic J, Prokselj K, Tul N, Cvijic M, Mirkovic T, Lucovnik M. Ocular ultrasonography for diagnosing increased intracranial pressure in patients with severe preeclampsia. Int J Obstet Anesth. 2018;36:49–55.

    Article  CAS  PubMed  Google Scholar 

  79. Lochner P, Nardone R, Tezzon F, Coppo L, Brigo F. Optic nerve sonography to monitor treatment efficacy in idiopathic intracranial hypertension: a case report. J Neuroimaging. 2013;23(4):533–4.

    Article  PubMed  Google Scholar 

  80. Lochner P, Brigo F, Zedde ML, Sanguigni S, Coppo L, Nardone R, Naldi A, Sola D, Stolz E. Feasibility and usefulness of ultrasonography in idiopathic intracranial hypertension or secondary intracranial hypertension. BMC Neurol. 2016;16:85.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Lochner P, et al. B-mode transorbital ultrasonography for the diagnosis of idiopathic intracranial hypertension: a systematic review and meta-analysis. Ultraschall Med. 2019;40(2):247–52.

    Article  PubMed  Google Scholar 

  82. Fichtner J, Ulrich CT, Fung C, Knüppel C, Veitweber M, Jilch A, Schucht P, Ertl M, Schömig B, Gralla J, Z'Graggen WJ, Bernasconi C, Mattle HP, Schlachetzki F, Raabe A, Beck J. Management of spontaneous intracranial hypotension—transorbital ultrasound as discriminator. J Neurol Neurosurg Psychiatry. 2016;87(6):650–5.

    Article  PubMed  Google Scholar 

  83. Dubost C, Le Gouez A, Zetlaoui PJ, Benhamou D, Mercier FJ, Geeraerts T. Increase in optic nerve sheath diameter induced by epidural blood patch: a preliminary report. Br J Anaesth. 2011;107(4):627–30.

    Article  CAS  PubMed  Google Scholar 

  84. Betcher J, Becker TK, Stoyanoff P, Cranford J, Theyyunni N. Military trainees can accurately measure optic nerve sheath diameter after a brief training session. Mil Med Res. 2018;5(1):42.

    PubMed  PubMed Central  Google Scholar 

  85. Maissan IM, Verbaan LA, van den Berg M, Houmes RJ, Stolker RJ, den Hartog D. Helicopter transportation increases intracranial pressure: a proof-of-principle study. Air Med J. 2018;37(4):249–52.

    Article  PubMed  Google Scholar 

  86. Houzé-Cerfon CH, Bounes V, Guemon J, Le Gourrierec T, Geeraerts T. Quality and feasibility of sonographic measurement of the optic nerve sheath diameter to estimate the risk of raised intracranial pressure after traumatic brain injury in prehospital setting. Prehosp Emerg Care. 2019;23(2):277–83.

    Article  PubMed  Google Scholar 

  87. Martin DS, Caine TL, Matz T, Lee SM, Stenger MB, Sargsyan AE, Platts SH. Virtual guidance as a tool to obtain diagnostic ultrasound for spaceflight and remote environments. Aviat Space Environ Med. 2012;83(10):995–1000.

    Article  PubMed  Google Scholar 

  88. Chiao L, Sharipov S, Sargsyan AE, Melton S, Hamilton DR, McFarlin K, Dulchavsky SA. Ocular examination for trauma; clinical ultrasound aboard the International Space Station. J Trauma. 2005;58(5):885–9.

    Article  PubMed  Google Scholar 

  89. Lizzi FL, Coleman DJ, Driller J, et al. Effects of pulsed ultrasound on ocular tissue. Ultrasound Med Biol. 1981;7:245–52.

    Article  CAS  PubMed  Google Scholar 

  90. Food and Drug Administration: Information for Manufacturers Seeking Clearance of Diagnostic Ultrasound Systems and Transducers; 2008. Available from: http://www.fda.gov/medicaldevices/deviceregulationandguidance/guidancedocuments/ucm070856.htm.

  91. Section 7–discussion of the mechanical index and other exposure parameters. American Institute of Ultrasound in Medicine. J Ultrasound Med. 2000;19:143–148, 54–68.

    Google Scholar 

  92. Ertl M, Barinka F, Torka E, Altmann M, Pfister K, Helbig H, Bogdahn U, Gamulescu MA, Schlachetzki F. Ocular color-coded sonography - a promising tool for neurologists and intensive care physicians. Ultraschall Med. 2014;35(5):422–31.

    Article  CAS  PubMed  Google Scholar 

  93. Shah S, Kimberly H, Marill K, Noble V. Ultrasound techniques to measure the optic nerve sheath: is a specialized probe necessary? Med Sci Monit. 2009;15:63–8.

    Google Scholar 

  94. Helmke K, Hansen HC. Fundamentals of transorbital sonographic evaluation of optic nerve sheath expansion under intracranial hypertension. I Experimental study. Pediatr Radiol. 1996;26:701–5.

    Article  CAS  PubMed  Google Scholar 

  95. Aspide R, Bertolini G, Albini Riccioli L, Mazzatenta D, Palandri G, Biasucci DG. A proposal for a new protocol for sonographic assessment of the optic nerve sheath diameter: the CLOSED protocol. Neurocrit Care. 2020;32(1):327–32.

    Article  PubMed  Google Scholar 

  96. Topcuoglu M, Arsava EM, Bas DF, Kozak HH. Transorbital ultrasonographic measurement of optic nerve sheath diameter in brain death. J Neuroimaging. 2015;25(6):906–9.

    Article  PubMed  Google Scholar 

  97. Krogias C, Ayzenberg I, Schroeder C, Gruter T, Gold R, Yoon MS. Transorbital sonography in CIDP patients: no evidence for optic nerve hypertrophy. J Neurol Sci. 2016;362:206–8.

    Article  PubMed  Google Scholar 

  98. Dubourg J, Javouhey E, Geeraerts T, Messerer M, Kassai B. Ultrasonography of optic nerve sheath diameter for detection of raised intracranial pressure: a systematic review and meta-analysis. Intensive Care Med. 2011;37(7):1059–68.

    Article  PubMed  Google Scholar 

  99. Soldatos T, Karakitsos D, Chatzimichail K, et al. Optic nerve sonography in the diagnostic evaluation of adult brain injury. Crit Care. 2008;12:R67.

    Article  PubMed  PubMed Central  Google Scholar 

  100. Geeraerts T, Launey Y, Martin L, et al. Ultrasonography of the optic nerve sheath may be useful for detecting raised intracranial pressure after severe brain injury. Intensive Care Med. 2007;33:1704–11.

    Article  PubMed  Google Scholar 

  101. Watanabe A, Kinouchi H, Horikoshi T, et al. Effect of intracranial pressure on the diameter of the optic nerve sheath. J Neurosurg. 2008;109:255–8.

    Article  PubMed  Google Scholar 

  102. Geeraerts T, Merceron S, Benhamou D, et al. Non-invasive assessment of intracranial pressure using ocular sonography in neurocritical care patients. Intensive Care Med. 2008;34:2062–7.

    Article  PubMed  Google Scholar 

  103. Le A, Hoehn ME, Smith ME, Spentzas T, Schlappy D, Pershad J. Bedside sonographic measurement of opticnerve sheath diameter as a predictor of increased intracranial pressure in children. Ann Emerg Med. 2009;53:785–91.58.

    Article  PubMed  Google Scholar 

  104. Young AMH, Guilfoyle MR, Donnelly J, Scoffings D, Fernandes H, Garnett M, et al. Correlating optic nerve sheath diameter with opening intracranial pressure in pediatric traumatic brain injury. Pediatr Res. 2017;81(3):443–7.

    Article  PubMed  Google Scholar 

  105. Steinborn M, Friedmann M, Makowski C, Hahn H, Hapfelmeier A, Juenger H. High resolution transbulbar sonography in children with suspicion of increased intracranial pressure. Childs Nerv Syst. 2016;32:655–60.

    Article  PubMed  Google Scholar 

  106. De Bernardo M, Vitiello L, Rosa N. Optic nerve sheath diameter ultrasound: optic nerve growth curve and its application to detect intracranial hypertension in children. Am J Ophthalmol. 2019;208:438.

    Article  PubMed  Google Scholar 

  107. Yu DY, Cringle SJ, Balaratnasingam C, Morgan WH, Yu PK, Su EN. Retinal ganglion cells: energetics, compartmentation, axonal transport, cytoskeletons and vulnerability. Prog Retin Eye Res. 2013;36:217–46.

    Article  CAS  PubMed  Google Scholar 

  108. Kerscher SR, Schöni D, Hurth H, Neunhoeffer F, Haas-Lude K, Wolff M, Schuhmann MU. The relation of optic nerve sheath diameter (ONSD) and intracranial pressure (ICP) in pediatric neurosurgery practice – Part I: correlations, age-dependency and cut-off values. Childs Nerv Syst. 2020;36(1):99–106.

    Article  PubMed  Google Scholar 

  109. Copetti R, Cattarossi L. Optic nerve ultrasound: artifacts and real images. Intensive Care Med. 2009;35:1488–9; author reply 1490–1481.

    Article  PubMed  Google Scholar 

  110. Rosa N, De Bernardo M. Ultrasound assessment of optic nerve sheath diameter in healthy volunteers. J Crit Care. 2017;40:279.

    Article  PubMed  Google Scholar 

  111. De Bernardo M, Rosa N. Clarification on using ultrasonography to detect intracranial pressure. JAMA Ophthalmol. 2017;135:1004–5. 4.

    Article  PubMed  Google Scholar 

  112. Rosa N, Vitiello L, De Bernardo M. Optic nerve sheath diameter measurement in hypoxic ischaemic brain injury after cardiac arrest. Resuscitation. 2019;138:310–1.

    Article  PubMed  Google Scholar 

  113. De Bernardo M, Vitiello L, Capone M, Rosa N. A-scan ultrasonography and optic nerve sheath diameter evaluation in children with acute liver failure. Liver Int. 2020;40(6):1504.

    Article  PubMed  Google Scholar 

  114. Robba C, Santori G, Czosnyka M, Corradi F, Citerio G. Optic nerve sheath diameter: the next steps. Intensive Care Med. 2019;45(12):1842–3.

    Article  PubMed  Google Scholar 

  115. Hansen HC, Helmke K. Optic nerve sheath responses to pressure variations. Intensive Care Med. 2019;45(12):1840–1.

    Article  CAS  PubMed  Google Scholar 

  116. Krishnamoorth V, Beckmann K, Mueller M, Sharma D, Vavilala M. Perioperative estimation of the intracranial pressure using the optic nerve sheath diameter during liver transplantation. Liver Transplant. 2013;19:246–9.

    Article  Google Scholar 

  117. Shofty B, Ben-Sira L, Constantini S, Freedman S. Optic nerve sheath diameter on MR imaging: establishment of norms and comparison of pediatric patients with idiopathic intracranial hypertension with healthy controls. Am J Neuroradiol. 2012;33:366–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  118. Legrand A, et al. Estimation of optic nerve sheath diameter on an initial brain computed tomography scan can contribute prognostic information in traumatic brain injury patients. Crit Care. 2013;17:R61.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Moretti R, Pizzi B, Cassini F, Vivaldi N. Reliability of optic nerve ultrasound for the evaluation of patients with spontaneous intracranial hemorrhage. Neurocrit Care. 2009;11:406.

    Article  PubMed  Google Scholar 

  120. Körber F, Scharf M, Moritz J, Dralle D. Sonography of the optical nerve – experience in 483 children. Rofo. 2005;177(2):229–35.

    Article  PubMed  Google Scholar 

  121. McAuley D, Paterson A, Sweeney L. Optic nerve sheath ultrasound in the assessment of paediatric hydrocephalus. Childs Nerv Syst. 2009;25(1):87–90.

    Article  PubMed  Google Scholar 

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Riggs, B.J., Hunt, M.F. (2022). Optic Nerve Sheath Diameter for Increased Intracranial Pressure. In: Ziai, W.C., Cornwell, C.L. (eds) Neurovascular Sonography . Springer, Cham. https://doi.org/10.1007/978-3-030-96893-9_17

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