Abstract
The performance of an operational PET scanner is affected by many factors, thus the detailed evaluation of imaging characteristics could contribute to ensuring the image quality. The routine quality assurance (QA) measurement of PET scanners can be used to provide an operational understanding of scanning properties. This study aims to compare the results obtained by the procedure for qualifying PET/CT scanners for clinical trials adopted by Guangdong Provincial People’s Hospital on both conventional (Biograph 16HR, Siemens) and total-body (uEXPLORER) PET/CT scanners. Uniform phantoms filled with 18F-FDG used in static mode and Ge-68 PET cylinders & transmission rod source used in dynamic mode have both been analyzed. This comparison study focuses on statistical characteristics and spatial correlation within the region of interest. We evaluate axial and transaxial patterns in mean, variance, and covariance. In general, voxel values of dynamic images are more skewed than static images, indicating that the Normal-based image post-processing algorithms might not be applicable for dynamic PET scans. Since variance characteristics are dominated by effective counts–these are lower in the axial extremes of the scanner bed, there is always a U-shaped of variance over axial locations in conventional PET scanners, while the static mode of the uEXPLORER scanner does not have. The spatial correlation between adjacent slices shows a potential connection with scanning settings. Therefore, there is a certain difference in imaging characteristics between conventional and whole-body PET scanners. In addition, information from routine phantom scanning would enrich the knowledge of image processing and give a novel method of comparative studies. Investigation of this approach is currently underway and will be reported in future work.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Brambilla, M., et al.: Performance characteristics obtained for a new 3-dimensional lutetium oxyorthosilicate-based whole-body PET/CT scanner with the national electrical manufacturers association NU 2–2001 standard. J. Nucl. Med. 46(12), 2083–2091 (2005)
Braune, A., Hofheinz, F., Bluth, T., Kiss, T., Wittenstein, J., Scharffenberg, M., Kotzerke, J., de Abreu, M.G.: Comparison of static and dynamic 18F-FDG PET/CT for quantification of pulmonary inflammation in acute lung injury. J. Nucl. Med. 60(11), 1629–1634 (2019)
Burchardt, E., Warenczak-Florczak, Z., Cegła, P., Piotrowski, A., Cybulski, Z., Burchardt, W., Roszak, A., Cholewiński, W.: Differences between [18F] FLT and [18F] FDG uptake in PET/CT imaging in CC depend on vaginal bacteriology. Diagnostics 12(1), 70 (2021)
Christian, P., et al.: Optimization of 89Zr-PET clinical imaging for multi-site improved quantification and lesion detection using an anthropomorphic phantom (2018)
Dondi, F., Pasinetti, N., Gatta, R., Albano, D., Giubbini, R., Bertagna, F.: Comparison between two different scanners for the evaluation of the role of 18F-FDG PET/CT semiquantitative parameters and radiomics features in the prediction of final diagnosis of thyroid incidentalomas. J. Clin. Med. 11(3), 615 (2022)
Girard, A., et al.: Impact of point-spread function reconstruction on dynamic and static 18F-DOPA PET/CT quantitative parameters in glioma. Quant. Imaging Med. Surg. 12(2), 1397 (2022)
Hanafi, M.H., Noor, N.M., Hassan, M.H.: Inconsistency of lesion quantitative assessment in 2D SUV and 3D SUV quantification techniques for [18F]-FDG PET/CT: a phantom study. Mal. J. Med. Health Sci. 17(2), 289–293 (2021)
Hoffmann, M.A., et al.: Comparison of [18F] PSMA-1007 with [68Ga] Ga-PSMA-11 PET/CT in restaging of prostate cancer patients with PSA relapse. Cancers 14(6), 1479 (2022)
Lantos, J., Mittra, E.S., Levin, C.S., Iagaru, A.: Standard OSEM vs. regularized PET image reconstruction: qualitative and quantitative comparison using phantom data and various clinical radiopharmaceuticals. Am. J. Nucl. Med. Mol. Imaging 8(2), 110 (2018)
Matheoud, R., et al.: Comparative analysis of iterative reconstruction algorithms with resolution recovery and time of flight modeling for 18F-FDG cardiac PET: a multi-center phantom study. J. Nucl. Cardiol. 24(3), 1036–1045 (2017)
Pfaehler, E., et al.: Experimental multicenter and multivendor evaluation of pet radiomic features performance using 3D printed phantom inserts. J. Nucl. Med. 61(3), 469–476 (2020). https://doi.org/10.2967/jnumed.119.229724
Shimada, N., et al.: A multi-center phantom study towards harmonization of FDG-PET: variability in maximum and peak SUV in relation to image noise (2020)
Shiri, I., Rahmim, A., Ghaffarian, P., Geramifar, P., Abdollahi, H., Bitarafan-Rajabi, A.: The impact of image reconstruction settings on 18F-FDG PET radiomic features: multi-scanner phantom and patient studies. Eur. Radiol. 27(11), 4498–4509 (2017)
Zhang, X., et al.: Total-body dynamic reconstruction and parametric imaging on the uexplorer. J. Nucl. Med. 61(2), 285–291 (2020)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Lin, Y., Liu, Et., Mou, T. (2022). Statistical Characteristics of 3-D PET Imaging: A Comparison Between Conventional and Total-Body PET Scanners. In: Yu, S., et al. Pattern Recognition and Computer Vision. PRCV 2022. Lecture Notes in Computer Science, vol 13535. Springer, Cham. https://doi.org/10.1007/978-3-031-18910-4_20
Download citation
DOI: https://doi.org/10.1007/978-3-031-18910-4_20
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-18909-8
Online ISBN: 978-3-031-18910-4
eBook Packages: Computer ScienceComputer Science (R0)