Skip to main content

Head and Neck Vessel Segmentation with Connective Topology Using Affinity Graph

  • Conference paper
  • First Online:
Machine Learning in Medical Imaging (MLMI 2022)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 13583))

Included in the following conference series:

  • 1300 Accesses

Abstract

Vessel segmentation is an important step for cerebrovascular disease analysis, while automatic and complete segmentation of head and neck vessels in CT angiography is a challenging problem. The reason is that vessels have diverse shapes and sizes in long and tortuous tubular-like vasculatures, as well as confounding appearance with surrounding tissues. Current deep learning-based methods often use voxel-wise segmentation, without considering the shape or connectivity of segmented vessels. In this paper, we describe vascular structures using affinity maps and construct connectivity priors of vessels so as to establish a topological connectivity loss for vessel segmentation. Specifically, a multi-head 3D U-Net is applied to predict the segmentation mask and the affinity map, and subsequently the connectivity-aware affinity map is used to refine the segmentation. In experiments, we applied our method on 72 head and neck CT angiography images. Voxel-wise and topology-relevant metrics show that the proposed method achieved superior performance than the widely used 3D nnU-Net and provided better 3D vessel visualization results.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Xu, G., Ma, M., Liu, X., Hankey, G.J.: Is there a stroke belt in china and why? Stroke 44(7), 1775–1783 (2013)

    Article  Google Scholar 

  2. Saxena, A., Ng, E.Y.K., Lim, S.T.: Imaging modalities to diagnose carotid artery stenosis: progress and prospect. Biomed. Eng. Online. 18(1), 1–23 (2019)

    Article  Google Scholar 

  3. Hedblom, A.: Blood vessel segmentation for neck and head computed tomography angiography (2013)

    Google Scholar 

  4. Cuisenaire, O., Virmani, S., Olszewski, M.E., Ardon, R.: Fully automated segmentation of carotid and vertebral arteries from contrast-enhanced CTA. In: Medical Imaging 2008: Image Processing, vol. 6914, p. 69143R. International Society for Optics and Photonics (2008)

    Google Scholar 

  5. Fan, F., et al.: Rapid vessel segmentation and reconstruction of head and neck angiograms using 3d convolutional neural network. Nat. Commun. 11(1), 1–12 (2020)

    Google Scholar 

  6. Xu, R., Liu, T., Ye, X., Lin, L., Chen, Y.-W.: Boosting connectivity in retinal vessel segmentation via a recursive semantics-guided network. In: Martel, A.L., et al. (eds.) MICCAI 2020. LNCS, vol. 12265, pp. 786–795. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-59722-1_76

    Chapter  Google Scholar 

  7. Paetzold, J.C., et al.: clDice-a novel connectivity-preserving loss function for vessel segmentation. In: Medical Imaging Meets NeurIPS 2019 Workshop (2019)

    Google Scholar 

  8. Funke, J., et al.: Large scale image segmentation with structured loss based deep learning for connectome reconstruction. IEEE Trans. Pattern Anal. Mach. Intell. 41(7), 1669–1680 (2018)

    Article  Google Scholar 

  9. Hu, X., Fuxin, L., Samaras, D., Chen, C.: Topology-preserving deep image segmentation. arXiv preprint arXiv:1906.05404 (2019)

  10. Qin, Y., et al.: AirwayNet: a voxel-connectivity aware approach for accurate airway segmentation using convolutional neural networks. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11769, pp. 212–220. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32226-7_24

    Chapter  Google Scholar 

  11. Kruskal, J.B.: On the shortest spanning subtree of a graph and the traveling salesman problem. Proc. Am. Math. Soc. 7(1), 48–50 (1956)

    Article  MathSciNet  MATH  Google Scholar 

  12. Çiçek, Ö., Abdulkadir, A., Lienkamp, S.S., Brox, T., Ronneberger, O.: 3D U-net: learning dense volumetric segmentation from sparse annotation. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 424–432. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46723-8_49

    Chapter  Google Scholar 

  13. Isensee, F., Jaeger, P.F., Kohl, S.A.A., Petersen, J., Maier-Hein, K.H.: nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation. Nat. Methods 18(2), 203–211 (2021)

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported in part by the National Key Research and Development Program of China under Grant 2018YFC0116400.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Qian Wang or Feng Shi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Yao, L. et al. (2022). Head and Neck Vessel Segmentation with Connective Topology Using Affinity Graph. In: Lian, C., Cao, X., Rekik, I., Xu, X., Cui, Z. (eds) Machine Learning in Medical Imaging. MLMI 2022. Lecture Notes in Computer Science, vol 13583. Springer, Cham. https://doi.org/10.1007/978-3-031-21014-3_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-21014-3_24

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-21013-6

  • Online ISBN: 978-3-031-21014-3

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics