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Toll-Like Receptors and Inflammasomes

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The Inflammasomes

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The recognition of microorganisms is mediated by germline pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) and nucleotide-binding domain, leucine-rich repeat-containing proteins (NLRs) that interact with conserved structures of the microorganisms, the pathogen-associated molecular patterns (PAMPs). PRRs activate intracellular signals that collaborate for efficient activation of host defense. One such specific collaboration is the interaction between TLRs and cytosolic NLRs. NLRs are the triggering components of the inflammasomes, and the combination of TLR and NLR signaling results in the activation of caspase-1, followed by processing and secretion of the highly proinflammatory cytokines IL-1β and IL-18. Understanding the mechanisms of interaction between TLRs and inflammasomes is important, since defects that influence this interaction might lead to autoinflammatory diseases or impaired host defense.

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Abbreviations

PRR:

Pattern recognition receptor

TLR:

Toll-like receptor

NLR:

Nucleotide-binding domain, leucine-rich repeat-containing protein

PAMP:

Pathogen-associated molecular patterns

IL:

Interleukin

TIR:

Toll/IL-1 receptor

LPS:

Lipopolysaccharide

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Author information

Authors and Affiliations

  1. Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

    Frank L. van de Veerdonk & Mihai G. Netea

  2. Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands

    Frank L. van de Veerdonk & Mihai G. Netea

Authors
  1. Frank L. van de Veerdonk
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  2. Mihai G. Netea
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Correspondence to Frank L. van de Veerdonk .

Editor information

Editors and Affiliations

  1. Institut de Transgénose, Labo. d'Immunologie et, CNRS, rue de la Férollerie 3B, Orléans CX 2, 45071, France

    Isabelle Couillin

  2. CNRS UMR 5201, Labo. Génétique et Cancer, Université de Lyon I, rue Laënnec 28, Lyon, 69008, France

    Virginie Pétrilli

  3. Dept. Immunology & Infectious, Diseases, Harvard School of Public Health, Huntington Ave. 651, Boston, 02115-6017, Massachusetts, USA

    Fabio Martinon

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van de Veerdonk, F.L., Netea, M.G. (2011). Toll-Like Receptors and Inflammasomes. In: Couillin, I., Pétrilli, V., Martinon, F. (eds) The Inflammasomes. Progress in Inflammation Research. Springer, Basel. https://doi.org/10.1007/978-3-0348-0148-5_8

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  • DOI: https://doi.org/10.1007/978-3-0348-0148-5_8

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  • Online ISBN: 978-3-0348-0148-5

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