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G-CSF Receptor Structure, Function, and Intracellular Signal Transduction

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Twenty Years of G-CSF

Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

The G-CSF receptor (G-CSFR), like other members of the type-I cytokine receptor family, is a single transmembrane-spanning protein lacking intrinsic kinase activity, and is composed of an extracellular cytokine receptor homologous (CRH) domain containing four conserved cysteine residues and a Trp-Ser-X-Trp-Ser (WSXWS, where X is a nonconserved amino acid) motif, and shared elements in the intracellular region denoted as Box 1 and Box 2 (Fig. 1). This receptor also comprises an immunoglobulin (Ig)-like domain and 3 fibronectin type III (FNIII)-like domains in the extracellular portion, as well as a cytoplasmic region containing a conserved sequence termed Box 3 [1, 2].

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Acknowledgments

HN-J is supported by an NIH predoctoral training grant in Cancer Immunology (T32-CA-09598-21). Related research in SSW’s laboratory has been supported by grants from the NIH (AI073587, AR059010), a Preclinical Research Agreement with Amgen Inc., and a seed grant from the Center for Stem Cell and Developmental Biology at UT M D Anderson Cancer Center.

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Authors and Affiliations

  1. Department of Immunology, Unit 902, MD Anderson Cancer Center, 301402, Houston, Texas, 77030, USA

    Hoainam T. Nguyen-Jackson, Huiyuan Zhang & Stephanie S. Watowich

  2. The Graduate School of Biomedical Sciences, University of Texas, Houston, TX, USA

    Hoainam T. Nguyen-Jackson

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  1. Hoainam T. Nguyen-Jackson
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  2. Huiyuan Zhang
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  3. Stephanie S. Watowich
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Correspondence to Stephanie S. Watowich .

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  1. Amgen Inc., One Amgen Center Drive, Thousand Oaks, 91320, California, USA

    Graham Molineux

  2. MA Foote Associates, Par Five Court 4284, Westlake Village, 91362, California, USA

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  3. Amgen, Inc., One Amgen Center Dr. 1, Thousand Oaks, 91320, California, USA

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Nguyen-Jackson, H.T., Zhang, H., Watowich, S.S. (2012). G-CSF Receptor Structure, Function, and Intracellular Signal Transduction. In: Molineux, G., Foote, M., Arvedson, T. (eds) Twenty Years of G-CSF. Milestones in Drug Therapy. Springer, Basel. https://doi.org/10.1007/978-3-0348-0218-5_6

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