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The Biology of Toll-Like Receptors and NOD-Like Receptors: The Toggles of Inflammation

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Genomics of Pattern Recognition Receptors

Abstract

We start this chapter with a brief description of what pattern recognition receptors are. Here, we denote the place of pattern recognition receptors in modern conception of immunology and write why we have chosen oncological and cardiological disorders to be considered in this book. Thereafter, we regard the structure and functioning of the most investigated group of pattern recognition receptors, namely Toll-like receptors (TLRs). Firstly, we consider the classification and structure of TLRs, then we depict a scheme of their interactions with other molecules downstream in the relevant signaling pathway, consider ligands which activate this pathway, and, finally, denote cells and organs where process of TLR signaling takes place. In general, we describe here the whole conception of TLRs in the human body. The last part of the chapter is devoted to the second deeply investigated group of pattern recognition receptors, namely NOD-like receptors. However, here we focus only on NOD1 and NOD2 due to their special relevance for the applied genomics. We describe the structure of these receptors, then we consider cells where they are expressed, their ligands, and, finally, depict a scheme of their functioning.

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Authors and Affiliations

  1. Epidemiology, Kemerovo State Medical Academy, Voroshilova Str. 22A, Kemerovo, Russia, 650029

    Anton G. Kutikhin

  2. Siberian Branch, Res Inst Cardiovascular Diseases, Russian Academy of Medical Sciences, Sosnovy Blvd. 6, Kemerovo, Russia, 650002

    Arseniy E. Yuzhalin

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  1. Anton G. Kutikhin
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Correspondence to Anton G. Kutikhin .

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Kutikhin, A.G., Yuzhalin, A.E. (2013). The Biology of Toll-Like Receptors and NOD-Like Receptors: The Toggles of Inflammation. In: Genomics of Pattern Recognition Receptors. Springer, Basel. https://doi.org/10.1007/978-3-0348-0688-6_1

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