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Intranasal Capsaicin in Management of Nonallergic (Vasomotor) Rhinitis

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Capsaicin as a Therapeutic Molecule

Part of the book series: Progress in Drug Research ((PDR,volume 68))

Abstract

Capsaicin is a selective transient receptor potential vanilloid 1 (TRPV1) ion channel agonist and has been demonstrated to reduce nerve conduction of nociceptive C fibers in the trigeminal nerve without affecting conduction in Aδ fibers. This chapter reviews the classification of chronic rhinitis subtypes, the prevalence and epidemiology of nonallergic rhinitis (NAR), postulated pathophysiology and mechanisms of NAR including the role of transient receptor potential (TRP) ion channels and discusses the potential therapeutic benefits of capsaicin in the treatment of chronic rhinitis subtypes, specifically NAR. Evidence supports that hypersensitivity of TRP ion channels on sensory afferent neurons innervating nasal mucosa is responsible for inducing NAR symptoms. These symptoms, characterized as excessive nasal glandular secretion, nasal congestion, and headache, are mediated through neuropeptide release during axonal and parasympathetic reflexes which are initiated by a spectrum of nonspecific irritants that activate TRP channels. Rational approaches to treat the pathophysiology of NAR would be to develop therapies with selective TRPV1 agonist activity like capsaicin that target desensitization of TRP ion channels on sensory afferent nerves.

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  1. Department of Internal Medicine, Division of Immunology/Allergy Section, University of Cincinnati College of Medicine, 3255 Eden Avenue, Suite 350, ML#563, Cincinnati, OH, 45267-0563, USA

    Umesh Singh & Jonathan A. Bernstein

  2. Bernstein Allergy Group, Inc, Cincinnati, OH, USA

    Umesh Singh & Jonathan A. Bernstein

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  1. Department of Toxicology and Narcotics, National Research Center, Cairo, Egypt

    Omar M. E. Abdel-Salam

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Singh, U., Bernstein, J.A. (2014). Intranasal Capsaicin in Management of Nonallergic (Vasomotor) Rhinitis. In: Abdel-Salam, O. (eds) Capsaicin as a Therapeutic Molecule. Progress in Drug Research, vol 68. Springer, Basel. https://doi.org/10.1007/978-3-0348-0828-6_6

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