Summary
The effects of long-term chronic post-test treatment with numerous typical (e.g., imipramine, desipramine, phenelzine) or atypical (alprazolam, trazodone, mianserin, buproprion) antidepressants on conflict behaviour in rats were determined. Chronic treatment with most agents (exceptions: mianserin, buproprion) resulted in a gradually-developing anti-conflict effect, with a latency to onset of 3–5 weeks. These data suggest that animal conflict paradigms might be effective animal procedures for studying the anxiolytic and/or anti-panic effects of antidepressant agents.
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© 1991 Springer Basel AG
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Commissaris, R.L., Fontana, D.J. (1991). A Potential Animal Model for the Study of Anti-Panic Treatments. In: Olivier, B., Mos, J., Slangen, J.L. (eds) Animal Models in Psychopharmacology. APS: Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6419-0_5
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DOI: https://doi.org/10.1007/978-3-0348-6419-0_5
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