Abstract
Angiogenic capacity, i.e. the property of inducing neovascularization is the rule for most neoplastic cells but the exception for normal tissues. When neoplastic cells from a V2 carcinoma were implanted in the vitreous body of a rabbit’s eye and their location was more than 2 mm from the retina, a nodule developed that reached a diameter of less than 1 mm and remained practically unchanged for weeks. However, if this nodule drifted towards the retina, within a few days it was colonized by microvessels and an explosive growth followed with formation of a solid tumor that destroyed the eye. Similar effects were observed when a mouse glioma was implanted in the rabbit vitreous [1].
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© 1992 Birkhäuser Verlag Basel/Switzerland
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Gullino, P.M. (1992). Microenvironment and angiogenic response. In: Steiner, R., Weisz, P.B., Langer, R. (eds) Angiogenesis. Experientia Supplementum, vol 61. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7001-6_20
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DOI: https://doi.org/10.1007/978-3-0348-7001-6_20
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-7003-0
Online ISBN: 978-3-0348-7001-6
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