Summary
Overexpression of P-glycoprotein genes is one established cause of multidrug resistance in mammalian cells. We are studying P-glycoproteins and their genes in man, in the mouse and in the nematode worm Caenorhabditis elegans in order to understand the normal, physiological role of P-glycoproteins, and the mechanistics of P-glycoprotein function. Our data suggest that one common, and evolutionarily well-conserved function of P-glycoproteins is protection of the organism against naturally occurring xenotoxins present in ingested food. We consider it likely, however, that some P-glycoprotein variants perform a more specialized function in the organism.
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© 1992 Birkhäuser Verlag, Basel/Switzerland
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Schinkel, A.H., Lincke, C.R., Smit, J.J.M., Borst, P. (1992). Structure and Function of P-Glycoproteins. In: Papa, S., Azzi, A., Tager, J.M. (eds) Adenine Nucleotides in Cellular Energy Transfer and Signal Transduction. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7315-4_35
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DOI: https://doi.org/10.1007/978-3-0348-7315-4_35
Publisher Name: Birkhäuser Basel
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