Abstract
Availability of free arachidonic acid (AA) is widely recognized as a rate-limiting step in the formation of prostaglandins. This fatty acid is an intermediate of a reacylation/deacylation cycle of membrane phospholipids, the so-called Lands pathway, in which the fatty acid is cleaved from phospholipid by phospholipase A2s (PLA2 ) and reincorporated by acyltransferases. Whereas in resting cells reacylation dominates, in stimulated cells the dominant reaction is the PLA2-mediated deacylation. Nevertheless, increased AA reacylation during cellular activation is still very significant, as manifested by the fact that only a minor portion of the free AA released by PLA2 is converted into eicosanoids, the remainder being effectively incorporated back into phospholipids.
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Balsinde, J., Pérez, R., Sáez, Y., Balboa, M.A. (2004). Control of arachidonic acid levels in resting and activated U937 phagocytic cells by Ca2+-independent phospholipase A2 . In: Fonteh, A.N., Wykle, R.L. (eds) Arachidonate Remodeling and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7848-7_4
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DOI: https://doi.org/10.1007/978-3-0348-7848-7_4
Publisher Name: Birkhäuser, Basel
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