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Cellular signaling to NF-кB: Role in inflammation and therapeutic promise

  • Conference paper
Inflammatory Processes:

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Recent advances in our understanding of the mediators involved in acute and chronic inflammatory diseases have led to new strategies in the search for effective therapeutics. Traditional approaches include direct target intervention such as the use of specific antibodies, receptor antagonists, or enzyme inhibitors. Breakthroughs in the knowledge of regulatory mechanisms involved in the transcription and translation of inflammatory mediators has led to increased interest in therapeutic approaches directed at the level of gene transcription. Of the transcription factors targeted for pharmacological intervention, NF-кB has drawn much interest in light of its role as a coordinating regulator in the expression of a variety of rapid-response genes involved in inflammatory and immune reactions. The activation of NF-кB, its migration to the nucleus, and its binding to DNA provide numerous potential points of intervention, some of which are discussed below.

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  1. Department of Immunology, SmithKline Beecham Pharmaceuticals, 709 Swedeland Rd, P.O. Box 1539, King of Prussia, PA, 19406, USA

    Marie Chabot-Fletcher

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  1. NitroMed Inc., 12 Oak Park Drive, Bedford, MA, 01730, USA

    L. Gordon Letts

  2. Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL, 60064, USA

    Douglas W. Morgan

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Chabot-Fletcher, M. (2000). Cellular signaling to NF-кB: Role in inflammation and therapeutic promise. In: Letts, L.G., Morgan, D.W. (eds) Inflammatory Processes:. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8468-6_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8468-6_3

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