Abstract
Two melanoma cell lines, SK-MEL-28 and 518 A2 were incubated for different time intervals up to 180 minutes at 37°C. With 99mTc-furifosmin, an uptake of 2%–3% was achieved almost immediately without any significant further change thereafter for a total monitoring period of 180 minutes. In contrast, the 99mTc-tetrofosmin-uptake (about 3%) was comparable up to about 60 minutes showing thereafter a significant (p<0.01) increase. These findings indicate that the kinetics and uptake mechnisms of these two tracers might be different. Thus, it needs to be further elucidated whether the increased late uptake of 99mTc-tetrofosmin might be relevant to be considered for clinical imaging protocols.
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© 1999 Springer Basel AG
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Susan, M. et al. (1999). 99mTc-Furifosmin Uptake by Melanoma Cells. In: Bergmann, H., Köhn, H., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research XXIII. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8782-3_26
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DOI: https://doi.org/10.1007/978-3-0348-8782-3_26
Publisher Name: Birkhäuser, Basel
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