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Electrical stimulation of the anterior cingulate cortex in a rat neuropathic pain model

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Advances in Functional and Reparative Neurosurgery

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 99))

Summary

Background. Electrical stimulation is currently employed to treat several neurological conditions, including pain and Parkinson’s disease. It is one of several minimally invasive alternatives to drug treatments for painful conditions. A number of studies have shown that the anterior cingulate cortex (ACC) plays an important role in the processing of pain and pain modulation. The purpose of this study is to investigate these neuropathic pain-relieving effects by delivering electrical stimulation into the ACC of rat models.

Methods. Following the approval of the AAALAC and the Guidelines and Regulations for Use and Care of Animals in Yonsei University, rats were subjected to surgery under pentobarbital anesthesia (50mg/kg, i.p.) to produce neuropathic pain. Electrodes were bilaterally implanted into the ACC with a metal holder for the electrical stimulation. The effect of the electrical stimulation of the ACC on the rat neuropathic pain model was measured by the von Frey test.

Findings. The effect of electrical stimulation of the ACC on neuropathic pain was shown during stimulation at 30, 40, 50, and 60 min, and at 10 min after stimulation. In the pain ACC stimulation group, the response of mechanical allodynia was significantly reduced during the time of ACC electrical stimulation.

Conclusion. The mechanical allodynia of the neuropathic pain could be modulated by ACC electrical stimulation.

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References

  1. Beurrier C, Bioulac B, Audin J, Hammond C (2001) High-frequency stimulation produces a transient blockade of voltagegated currents in subthalamic neurons. J Neurophysiol 85: 1351–1356

    PubMed  CAS  Google Scholar 

  2. Calejesan AA, Kim SJ, Zhuo M (2000) Descending facilitatory modulation of a behavioral nociceptive response by stimulation in the adult rat anterior cingulate cortex. Eur J Pain 4: 83–96

    Article  PubMed  CAS  Google Scholar 

  3. Casey KL, Minoshima S, Berger KL, Koeppe RA, Morrow TJ, Frey KA (1994) Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli. J Neurophysiol 71: 802–807

    PubMed  CAS  Google Scholar 

  4. Davis KD, Taylor SJ, Crawley AP, Wood ML, Mikulis DJ (1997) Functional MRI of pain-and attention-related activations in the human cingulate cortex. J Neurophysiol 77: 3370–3380

    PubMed  CAS  Google Scholar 

  5. Devinsky O, Morrell MJ, Vogt BA (1995) Contributions of anterior cingulate cortex to behaviour. Brain 118 (Pt 1): 279–306

    Article  PubMed  Google Scholar 

  6. Dostrovsky JO, Lozano AM (2002) Mechanisms of deep brain stimulation. Mov Disord 17[Suppl] 3: S63–S68

    Article  PubMed  Google Scholar 

  7. Dowdall T, Robinson I, Meert TF (2005) Comparison of five different rat models of peripheral nerve injury. Pharmacol Biochem Behav 80: 93–108

    Article  PubMed  Google Scholar 

  8. Erel U, Arborelius L, Brodin E (2004) Increased cholecystokinin release in the rat anterior cingulate cortex during carrageenaninduced arthritis. Brain Res 1022: 39–46

    Article  PubMed  CAS  Google Scholar 

  9. Garcia-Larrea L, Peyron R, Mertens P, Gregoire MC, Lavenne F, Le Bars D, Convers P, Mauguiere F, Sindou M, Laurent B (1999) Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study. Pain 83: 259–273

    Article  PubMed  CAS  Google Scholar 

  10. Hsu MM, Shyu BC (1997) Electrophysiological study of the connection between medial thalamus and anterior cingulate cortex in the rat. Neuroreport 8: 2701–2707

    Article  PubMed  CAS  Google Scholar 

  11. Hutchison WD, Davis KD, Lozano AM, Tasker RR, Dostrovsky JO (1999) Pain-related neurons in the human cingulate cortex. Nat Neurosci 2: 403–405

    Article  PubMed  CAS  Google Scholar 

  12. Jones AK, Friston KJ, Qi LY, Harris M, Cunningham VJ, Jones T, Feinman C, Frackowiak RS (1991) Sites of action of morphine in the brain. Lancet 338: 825

    Article  PubMed  CAS  Google Scholar 

  13. Lee BH, Won R, Baik EJ, Lee SH, Moon CH (2000) An animal model of neuropathic pain employing injury to the sciatic nerve branches. Neuroreport 11: 657–661

    Article  PubMed  CAS  Google Scholar 

  14. Lei LG, Sun S, Gao YJ, Zhao ZQ, Zhang YQ (2004) NMDA receptors in the anterior cingulate cortex mediate pain-related aversion. Exp Neurol 189: 413–421

    Article  PubMed  CAS  Google Scholar 

  15. Meyerson BA, Lindblom U, Linderoth B, Lind G, Herregodts P (1993) Motor cortex stimulation as treatment of trigeminal neuropathic pain. Acta Neurochir [Suppl] 58: 150–153

    CAS  Google Scholar 

  16. Moser A, Gieselberg A, Ro B, Keller C, Qadri F (2003) Deep brain stimulation: response to neuronal high frequency stimulation is mediated through GABA(A) receptor activation in rats. Neurosci Lett 341: 57–60

    Article  PubMed  CAS  Google Scholar 

  17. Ortega-Legaspi JM, Lopez-Avila A, Coffeen U, del Angel R, Pellicer F (2003) Scopolamine into the anterior cingulate cortex diminishes nociception in a neuropathic pain model in the rat: an interruption of ‘nociception-related memory acquisition’? Eur J Pain 7: 425–429

    Article  PubMed  CAS  Google Scholar 

  18. Peyron R, Garcia-Larrea L, Deiber MP, Cinotti L, Convers P, Sindou M, Mauguiere F, Laurent B (1995) Electrical stimulation of precentral cortical area in the treatment of central pain: electrophysiological and PET study. Pain 62: 275–286

    Article  PubMed  CAS  Google Scholar 

  19. Peyron R, Laurent B, Garcia-Larrea L (2000) Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiol Clin 30: 263–288

    Article  PubMed  CAS  Google Scholar 

  20. Rushton DN (2002) Electrical stimulation in the treatment of pain. Disabil Rehab 24: 407–415

    Article  Google Scholar 

  21. Talbot JD, Marrett S, Evans AC, Meyer E, Bushnell MC, Duncan GH (1991) Multiple representations of pain in human cerebral cortex. Science 251: 1355–1358

    Article  PubMed  CAS  Google Scholar 

  22. Tasker RR, Vilela Filho O (1995) Deep brain stimulation for neuropathic pain. Stereotact Funct Neurosurg 65: 122–124

    Article  PubMed  CAS  Google Scholar 

  23. Treede RD, Kenshalo DR, Gracely RH, Jones AK (1999) The cortical representation of pain. Pain 79: 105–111

    Article  PubMed  CAS  Google Scholar 

  24. Tsubokawa T, Katayama Y, Yamamoto T, Hirayama T, Koyama S (1991) Chronic motor cortex stimulation for the treatment of central pain. Acta Neurochir [Suppl] 52: 137–139

    CAS  Google Scholar 

  25. Velisek L, Veliskova J, Moshe SL (2002) Electrical stimulation of substantia nigra pars reticulata is anticonvulsant in adult and young male rats. Exp Neurol 173: 145–152

    Article  PubMed  Google Scholar 

  26. Vogt BA, Berger GR, Derbyshire SW (2003) Structural and functional dichotomy of human midcingulate cortex. Eur J Neurosci 18: 3134–3144

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. School of Electrical & Computing Engineering, Seoul National University, Seoul, Korea

    S. I. Park & S. J. Kim

  2. Nano Bioelectronics and System Research Center, Seoul National University, Seoul, Korea

    S. I. Park, Y. S. Hwang, S. J. Kim & J. W. Chang

  3. Department of Neurosurgery, Yonsei University College of Medicine, 134 Shinchondong Seodamunku, Seoul, 128-752, Korea

    J. H. Oh, Y. S. Hwang & J. W. Chang

  4. Medical Research Center, Yonsei University College of Medicine, Seoul, Korea

    J. H. Oh & Y. S. Hwang

  5. BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea

    J. H. Oh, Y. S. Hwang & J. W. Chang

Authors
  1. S. I. Park
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  2. J. H. Oh
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  3. Y. S. Hwang
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  4. S. J. Kim
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  5. J. W. Chang
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Correspondence to J. W. Chang .

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Editors and Affiliations

  1. Yonsei University College of Medicine, Seoul, Korea

    Jin Woo Chang

  2. Nihon University, Tokyo, Japan

    Yoichi Katayama  & Takamitsu Yamamoto  & 

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© 2006 Springer-Verlag

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Park, S.I., Oh, J.H., Hwang, Y.S., Kim, S.J., Chang, J.W. (2006). Electrical stimulation of the anterior cingulate cortex in a rat neuropathic pain model. In: Chang, J.W., Katayama, Y., Yamamoto, T. (eds) Advances in Functional and Reparative Neurosurgery. Acta Neurochirurgica Supplementum, vol 99. Springer, Vienna. https://doi.org/10.1007/978-3-211-35205-2_13

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  • DOI: https://doi.org/10.1007/978-3-211-35205-2_13

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-35204-5

  • Online ISBN: 978-3-211-35205-2

  • eBook Packages: MedicineMedicine (R0)

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