Abstract
Despite modern advances in surgery, subarachnoid haemorrhage (SAH) continues to carry high morbidity and mortality rates. The reasons for this are currently unclear. It is certain however that vasospasm is not the only modality responsible for this. As a result the concept of Early Brain Injury (EBI) has been introduced in an effort to focus attention on other aspects of SAH. EBI occurs within the first 72 h after a SAH and encompasses the complex pathophysiological events that occur in the brain at the moment of a SAH and shortly thereafter. It has been hypothesised that these events may be responsible for many of the long term consequences of SAH that have to date remained poorly understood. The key component of EBI is apoptosis, evidence of which has been previously noted on autopsy studies. Detailed knowledge of the apoptotic pathways in relation to SAH may provide useful therapeutic options for the treatment of patients with SAH in the future.
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Cahill, J., Zhang, J.H. (2008). Pre-vasospasm: early brain injury. In: Kırış, T., Zhang, J.H. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplement, vol 104. Springer, Vienna. https://doi.org/10.1007/978-3-211-75718-5_2
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