Abstract
The development of micro-fluidic devices to support the systemic circulation of blood has been used either as a temporary bridge or as a recovery method to treat different heart diseases. Blood flow through these artificial micro-channels is a major challenge because blood at scales from tens to hundreds of microns behaves as a multiphase suspension of deformable particles. A homogeneous model of blood is not adequate if the effect of cell segregation through these devices is of interest to evaluate blood cell damage (e.g., hemolysis or thrombosis). To determine the flow field and model the occurrence of segregation, an Eulerian frame of reference is employed. The simulations are performed in a tube of internal diameter of 217 \(\upmu \)m. We find that the results contribute to improve the understanding of the fluid dynamics of blood as a multi-component medium. Our simulations are based on an alternative methodology for blood modelling at a lower computational cost compared to DNS.
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Acknowledgments
The authors gratefully acknowledge the financial support from Universidad Simón Bolívar’s Deanship of Research and Development under a Research Assistantship grant. Thanks also to the Laboratory of Fluid Mechanics at the Universidad Simón Bolívar, whose PC cluster hosted a large number of the simulations performed in this investigation, and supplied the ANSYS CFX licenses for the study. We would also like to thank Dr. Samuel Hund and Dr. James Antaki for their insightful guidelines and suggestions on benchmark databases to compare with our numerical model.
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Mubita, T.M., Rojas-Solórzano, L.R., Moreno, J.B. (2014). A Multiphase Approach to Model Blood Flow in Micro-tubes. In: Sigalotti, L., Klapp, J., Sira, E. (eds) Computational and Experimental Fluid Mechanics with Applications to Physics, Engineering and the Environment. Environmental Science and Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-00191-3_11
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DOI: https://doi.org/10.1007/978-3-319-00191-3_11
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