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Ryanodine and Inositol Trisphosphate Receptors/Ca2+ Release Channels in Airway Smooth Muscle Cells

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Calcium Signaling In Airway Smooth Muscle Cells

Abstract

Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) are the most important Ca2+ release channels on the sarcoplasmic (or endoplasmic) reticulum (SR) in almost all types of cells. In the past several decades, the studies of RyRs and IP3Rs have greatly facilitated our understanding of the physiological functions and pathological mechanisms for various diseases including heart failure, arrhythmias, myopathy, and seizure. Similarly, their important roles have been explored in airway smooth muscle cells (SMCs). These two receptors control intracellular Ca2+ release and modulate extracellular Ca2+ influx, thereby playing an essential role in cell contraction, relaxation, proliferation, migration, metabolism, and, ultimately, cell fate. The abnormality of Ca2+ signaling in airway SMCs may contribute to the development of multiple lung diseases, notably asthma. Concomitantly, many regulators, including Ca2+ itself, calmodulin, protein kinases, FK506-binding protein 12.6 (FKBP12.6), cyclic adenosine diphosphate ribose (cADPR), and redox status, are involved in the regulation of Ca2+ signaling and, thus, the physiological function and pathological alterations. The two SR Ca2+ release channels may also directly or indirectly interact with plasmalemmal and mitochondrial ion channels such as transient receptor potential cation, big-conductance Ca2+-activated K+, Ca2+-activated Cl−, and other channels, providing positive or negative feedback mechanisms to control Ca2+ signaling and cellular functions.

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Abbreviations

2-APB:

2-aminoethoxy-diphenylborate

ACh:

Acetylcholine

BKCa :

Big-conductance Ca2+-activated K+ channel

cADPR:

Cyclic adenosine diphosphate ribose

CaMKII:

Calmodulin-dependent protein kinase II

CICR:

Ca2+-induced Ca2+ release

ClCa :

Ca2+-activated Cl− channel

CPVT:

Catecholaminergic polymorphic ventricular tachycardia

DAG:

Diacylglycerol

FKBP12.6:

FK506-binding protein 12.6

GPX1:

Glutathione peroxidase-1

H2O2 :

Hydrogen peroxide

IL-13:

Interleukin-13

IP3Rs:

Inositol 1,4,5-trisphosphate receptors

IRAG:

cGMP kinase substrate

LTCCs:

L-type voltage-gated Ca2+ channels

LTD4:

Leukotriene D4

M3R:

Muscarinic M3 receptor

mACh:

Methacholine

MLC:

Myosin light chain

MLCK:

Myosin light chain kinase

MLCP:

Myosin light chain phosphatase

mTOR:

Mammalian target of rapamycin

NCX:

Na+/Ca2+ exchanger

NO:

Nitric oxide

NSCCs:

Nonselective cation channels

PI3K:

Phosphatidylinositol 3 kinases

PIP2:

Phosphatidylinositol 4 5-bisphosphate

PKA:

Protein kinase A

PKC:

Protein kinase C

PKG:

cGMP-dependent protein kinase

PLC:

Phospholipase C

ROS:

Reactive oxygen species

RyR:

Ryanodine receptor

SERCA:

Sarcoplasmic reticulum Ca2+ ATPase

SMC:

Smooth muscle cell

SOCE:

Store-operated calcium entry

SR:

Sarcoplasmic reticulum

STIC:

Spontaneous transient inward current

STOC:

Spontaneous transient outward current

TNF-α:

Tumor necrosis factor-α

TRP:

Transient receptor potential channel

VICR:

Voltage-induced Ca2+ release

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  1. Center for Cardiovascular Sciences (MC-8), Albany Medical College, 47 New Scotland Avenue, Albany, NY, 12208, USA

    Lin Mei, Yun-Min Zheng & Yong-Xiao Wang

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  1. Lin Mei
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  2. Yun-Min Zheng
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  3. Yong-Xiao Wang
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Correspondence to Yun-Min Zheng or Yong-Xiao Wang .

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  1. Albany Medical College Center for Cardiovascular Sciences, Albany, New York, USA

    Yong-Xiao Wang

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Mei, L., Zheng, YM., Wang, YX. (2014). Ryanodine and Inositol Trisphosphate Receptors/Ca2+ Release Channels in Airway Smooth Muscle Cells. In: Wang, YX. (eds) Calcium Signaling In Airway Smooth Muscle Cells. Springer, Cham. https://doi.org/10.1007/978-3-319-01312-1_1

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