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Genetic and Developmental Origins of Food Preferences and Obesity Risk: The Role of Dopamine

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Hormones, Intrauterine Health and Programming

Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI,volume 12))

Abstract

Fetal growth and development associates with poor lifetime health outcomes. Despite the strength of the epidemiological evidence, there is little research that describes the functional pathways linking fetal development to brain-based disorders and metabolic health. We used a longitudinal cohort (Maternal Adversity, Vulnerability and Neurodevelopment; MAVAN) to study children of mothers recruited at mid-gestation and examine neurodevelopmental outcomes focusing on the association between birth weight and phenotypes associated with attention deficit disorder and obesity. These studies provide preliminary support for a ‘thrifty’ eating hypothesis that emphasizes the potential adaptive value of altered appetite regulation in the face of predicted nutritional deprivation, with impaired fetal growth as a marker for the in utero states that would produce such a prediction. We suggest that the effects might be mediated by altered activity across the mesocorticolimbic dopamine.

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Author information

Authors and Affiliations

  1. Departamento de Pediatria, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brazil

    Patricia P. Silveira

  2. Department of Psychiatry and Physiology, University of Toronto and Centre for Addiction and Mental Health, Toronto, ON, Canada

    James L. Kennedy & Robert D. Levitan

  3. Department of Ecology and Evolutionary Biology, Institute for Human Development, University of Toronto, Toronto, ON, Canada

    Marla B. Sokolowski

  4. Department of Psychiatry and Neurology, Douglas Mental Health University Institute, McGill University, 6875 Boul LaSalle, Montréal, QC, Canada, H4H 1R3

    Michael J. Meaney

  5. Singapore Institute for Clinical Sciences, Singapore, Singapore

    Michael J. Meaney

Authors
  1. Patricia P. Silveira
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  2. James L. Kennedy
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  3. Marla B. Sokolowski
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  4. Robert D. Levitan
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  5. Michael J. Meaney
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Corresponding author

Correspondence to Michael J. Meaney .

Editor information

Editors and Affiliations

  1. Endocrinology Unit, University of Edinburgh Queen's Medical Research Inst, Edinburgh, United Kingdom

    Jonathan R Seckl

  2. Fondation IPSEN, Boulogne-Billancourt Cedex, France

    Yves Christen

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Silveira, P.P., Kennedy, J.L., Sokolowski, M.B., Levitan, R.D., Meaney, M.J. (2014). Genetic and Developmental Origins of Food Preferences and Obesity Risk: The Role of Dopamine. In: Seckl, J., Christen, Y. (eds) Hormones, Intrauterine Health and Programming. Research and Perspectives in Endocrine Interactions, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-319-02591-9_11

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